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All Journal Indonesian Journal of Medical Chemistry and Bioinformatics Ophthalmologica Indonesiana
Zahra, Raihanny Andrea
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Chemistry Computer Science & IT Health Professions Medicine & Pharmacology Public Health

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OVERVIEW OF PATIENTS SCREENED FOR AND DIAGNOSED WITH ROP IN PEDIATRIC OPHTHALMOLOGY OUTPATIENT CLINIC BEFORE, DURING, AND AFTER THE COVID-19 PANDEMIC: Poster Presentation - Observational Study - Ophthalmologist BARLIANA, JULIE DEWI; Sitorus, Rita Rita; Yulia, Dian Estu; Casey, Anthea; Zahra, Raihanny Andrea
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/hwpgv162

Abstract

Introduction & Objectives : The COVID-19 pandemic has profoundly impacted healthcare systems worldwide, leading to significant changes in the delivery of medical services. Non-urgent ophthalmology visits were canceled. However, premature infants at risk of retinopathy of prematurity (ROP) require timely and in-person care to prevent vision loss. This study aims to report on the high-risk babies screened and diagnosed with ROP before, during, and after the COVID-19 pandemic Methods : This is a descriptive study conducted on premature infants who visited the pediatric ophthalmology outpatient clinic at Cipto Mangunkusumo Hospital Jakarta between January 2019 and December 2022. Data was collected using medical records and presented using tables and charts Results : A total of 368 babies were screened for ROP in 2019, and 75% were diagnosed with ROP. During the lockdown in 2020, the number of babies screened for ROP decreased to 286, and the incidence of ROP was 38.5%. In 2021 and 2022, ROP screening increased to 458 and 515 babies per year, respectively. After the COVID-19 pandemic subsided, ROP screenings increased significantly from 2020 to 2021. The number of babies screened in 2021 and 2022 was similar, but the incidence of ROP decreased from 45.4% in 2021 to 20.3% in 2022 Conclusion : This study highlights the impact of the COVID-19 pandemic on ROP screening and diagnosis in a pediatric ophthalmology outpatient clinic. After the COVID-19 pandemic, the number of babies screened for ROP increased due to the end of the lockdown
Single Nucleotide Polymorphisms in Plasmodium falciparum Genes: Their Roles in Antimalarial Drugs Resistance and Recent Detection Strategies Zahra, Raihanny Andrea; Fanshur, Ananda Maulana; Saraswati, Aurelia Maria Prajna; Rahmani, Nurul Inayah
Indonesian Journal of Medical Chemistry and Bioinformatics Vol. 2, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction: Malaria is a serious tropical disease with Plasmodium falciparum as its most well-known causative parasite for producing higher levels of late stage parasites that leads to sequestration in vital organs which could lead to death. There is a growing trend of antimalarial drugs resistance against Plasmodium falciparum. Molecular assessment using polymerase chain reaction could trace the presence of mutation and also determine single-nucleotide polymorphism (SNP) in Plasmodium falciparum genes. This SNP can determine the particular population’s response to antimalarial drugs. Objectives: This study aims to examine the relationship between SNP in Plasmodium falciparum genes and antimalarial drugs resistance. Methods: Literature searches were carried out through various databases which were then collected and analyzed. Result: We identified various SNPs from eleven known genes in Plasmodium falciparum, each SNPs causes a different mechanism which contributes to antimalarial drug resistance. Mechanisms varying from slower drug clearance to drug transport activity alteration. Conclusion: Results from most studies included in this review suggest that SNPs in Plasmodium falciparum genes participate in the resistance against various antimalarial drugs via several mechanisms and may be necessary for parasite survival when stressed.
Co-Authors Casey, Anthea Estu Yulia, Dian Fanshur, Ananda Maulana Julie Dewi Barliana Rahmani, Nurul Inayah Saraswati, Aurelia Maria Prajna Sitorus, Rita Rita