Estu Yulia, Dian
Department Of Ophthalmology, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia

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Successful Management of Complex Congenital Cataract and Its Complication: A Case Report: Keberhasilan Tatalaksana Katarak Kongenital Kompleks dan Komplikasinya: Sebuah Laporan Kasus Dian Estu Yulia; Yulika Harniza; Lia Amanda
eJournal Kedokteran Indonesia Vol 10, No. 3 - Desember 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.58.265-70

Abstract

Management of cataract and its complication after surgery in a child with complex congenital cataract where accompanied by other ocular abnormality can pose a great surgical challenge. This case report described a case of an 18-year-old girl with slowly decreasing vision after undergoing surgery charity on the right eye (RE) around 4 months ago due to cataract which she had since birth. Best corrected visual acuity (BCVA) preoperatively of the RE and LE was 6/60 and 0,5/60 respectively. Ocular assessment was pseudophakia with Posterior Capsular Opacity (PCO) on the RE and cataract on the left eye (LE) accompanied by microcornea, nystagmus and coloboma of iris and retina on both eyes. Secondary posterior capsulotomy surgery was done on the RE and cataract extraction, Primary Posterior Capsulotomy (PPC) on the LE with Anterior Vitrectomy (AV) on both eyes. Last follow-up postoperatively showed a significant improvement of uncorrected visual acuity on her RE from 0.5/60 preoperatively to 6/30, meanwhile only subjective improvement of VA was found on her LE. This case can achieve visual improvement with promptly surgical treatment without complication and routine monitoring still needs to be done.
CLINICAL OUTCOMES OF SURGERY FOR ADVANCED STAGE RETINOPATHY OF PREMATURITY: A CASE REPORT Dian Estu Yulia; Marissa Jayawinata; Mario Marbungaran Hutapea
International Journal of Retina Vol 6 No 1 (2023): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2023.vol006.iss001.210

Abstract

Introduction: Advanced stages of Retinopathy of Prematurity (ROP) could lead to childhood blindness and retinal surgery is needed as the main treatment. This case aims to report the clinical outcomes after surgery for advanced-stage ROP Case Report: A female infant was admitted to the pediatric ophthalmology clinic in Cipto Mangunkusumo National Central Hospital Jakarta with a lack of visual contact in both eyes at 53 weeks of Post Menstrual Age (PMA). The infant was delivered at 28 weeks of gestational age with a birth weight of 1100 g. The baby was treated in NICU for 24 days and received oxygen therapy in the previous hospital. Retinal examination revealed that the patient had stage 5 ROP in the right eye and stage 4B ROP in the left eye. Furthermore, blinking reflect was absent in both eyes. Vitrectomy and endolaser were performed for the baby’s left eye. Surgery was not conducted for the infant’s right eye due to poor prognosis. Six weeks after surgery, the infant underwent examination under anesthesia (EUA) which showed that the retina was reattached with no vitreous hemorrhage, and intraocular pressure measurement was 7 mmHg. The result of the visual acuity test by Cardiff Acuity Cards was 6/60 on both eyes. Followed up EUA reported that the refraction test result on the left eye was S-3.75 C-5.75 x 85o and an undetermined result on the right eye due to opacity in the visual axis. Discussion: Several surgeries have been described as the treatment of choice for advanced-stage ROP, including scleral buckling and vitrectomy with or without the addition of endolaser. Previous studies illustrated that stage 5 ROP has a low success rate on lens-sparing vitrectomy compared to stage 4A and 4B. The outcome success rate was the best in stage 4A ROP. Moreover, stage 4B ROP had a moderate success rate with sufficient visual outcomes. Conclusion: The functional outcome of vitrectomy surgery may not equate to anatomic success. Retinal reattachment and moderate visual outcome were achieved by performing vitrectomy and endolaser in this case. Followed-up periodically is necessary for advanced stage ROP postoperatively.
FACTORS THAT INFLUENCE SURVIVAL RATE IN EXTRAOCULAR RETINOBLASTOMA PATIENTS AT CIPTO MANGUNKUSUMO HOSPITAL : 2018 Dwie Aprina; Julie Dewi Barliana; Dian Estu Yulia; Rita Sita Sitorus
Majalah Oftalmologi Indonesia Vol 50 No 1 (2024): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/fvstnp93

Abstract

Introduction: Optimal therapeutic approach for extraocular retinoblastoma has not been determined. The prognosis of extraocular retinoblastoma compared with intraocular retinoblastoma remains relatively poor. The aim of our study is to describe the factors that influence the survival rate of extraocular retinoblastoma. Methods: A retrospective study. Patients diagnosed with extraocular retinoblastoma in Cipto Mangunkusumo Hospital, within 1 January to 31 December 2018 were reviewed for patient and tumor characteristic, ocular management, and patient survival. Result: During the study period, a total of  80 patients were diagnosed with retinoblastoma in our center, 41.2% had an extra-ocular extension The mean age at diagnosis was 25.57 months, with 56.7% being males. Leukocoria is the initial sign most often noticed by parents. The median lag period was 12 months. Neoadjuvant chemotherapy was performed in 96.7% of cases, that carried out an average of 3-4 cycles before enucleation/exenteration. At the end of September 2019, there were 17 deaths in our study. Overall survival was 19.82 months with a mean age of 27.6 months, whereas extraocular death time ranged from 4 months to 55 months.  Conclusion: Death was more common in patients with age at first symptom less than 24 months, bilateral retinoblastoma, lag period more than 12 months, advanced stage (IVB) and delayed therapy after proptosis more than 3 months.
Childhood blindness from surge of advanced stage retinopathy of prematurity in premature infants during the COVID-19 pandemic: a case series Dian Estu Yulia; Diajeng Ayesha Soeharto
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.360-367

Abstract

Background Retinopathy of prematurity (ROP) is a proliferative disease of the ocular retinal vasculature in premature infants, being a leading cause of preventable childhood blindness. The COVID-19 pandemic serves as an additional barrier to access to care and referral, potentially leading to more cases of advanced stage ROP. Although surgery can be done, ROP at this stage is highly associated with poor functional outcome irrespective of surgery. This case series aims to report advanced stage (stage 5) ROP in premature infants during the COVID-19 pandemic. MethodsA retrospective case series of medical records of paediatric patients with ROP was performed at Cipto Mangunkusumo National Referral Hospital between March 1, 2020 and December 31, 2021. This case series included new patients that presented to our clinic from March 2020 to December 2021 with stage 5 ROP. ResultsA total of 19 eyes of 10 patients with stage 5 ROP were included in this study. Mean chronologic age at presentation to our referral centre was 7.0 4.0 months. Upon presentation, all had stage 5 ROP with negative blink reflex to light, and none of the eyes in this cohort underwent surgical intervention. Mean gestational age was 30.3 3.2 weeks and mean birth weight was 1,276.7 366.4 g. ConclusionThere was an observable surge of stage 5 ROP at our referral centre with irreversible blindness. This highlights the need for proper ROP screening in all hospitals in Indonesia to prevent delay in detection and care of advanced stage ROP.
Clinical Characteristics of Children with Refrative Amblyopia at Cipto Mangunkusumo National Referral Hospital Yulia, Dian Estu; Barliana, Julie Dewi; Sitorus, Rita Sita; Putri, Meuthia Rana; Soeharto, Diajeng Ayesha
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i1.7582

Abstract

Amblyopia, commonly referred to as 'lazy eye’, manifests as a reduction in best corrected visual acuity (BCVA) in the absence of detectable ocular structural abnormalities. Refractive amblyopia specifically denotes a subtype of amblyopia arising from uncorrected refractive errors. A retrospective descriptive analysis was conducted on medical records of all pediatric patients with refractive amblyopia at the Department of Ophthalmology, Cipto Mangunkusumo Kirana National Referral Hospital, Jakarta, Indonesia in 2018 to 2022. A total of 391 eyes of 224 patients were included. Median age was 8 (5-18) years, with majority being older than 7 years of age (58.7%). Leading method of treatment was with spectacles alone (80.4%). Overall amblyopia improvement was mostly observed after six months of treatment. In conclusion, refractive amblyopia at our hospital was highly prevalent among children. Thus, early detection and treatment of refractive errors in children is essential to prevent refractive amblyopia.
Profile of Refractive Errors in Children at dr. Cipto Mangunkusumo Hospital: Profile of Refractive Errors in Children Yulia, Dian Estu; Barliana, Julie Dewi; Soeharto, Diajeng Ayesha; Tan, Sabrina
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.839.75

Abstract

Refractive errors, notably myopia, are highly prevalent in Asian countries, with a notable increase observed in the pediatric population. This surge is attributed to lifestyle changes such as less time outdoors and increased exposure to digital screens and near-work activities, which are known to elevate myopia risk. A retrospective review of medical records was conducted at the Department of Ophthalmology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from 2020 to 2022, identifying 290 eyes of 146 children with refractive errors. Myopia emerged as the most prevalent refractive error, affecting 53.4% of eyes in this study. The median age of the participants was 8 years old, with 56.8% being females and 65.8% residing in Jakarta. Early detection and management of refractive errors are crucial to prevent irreversible visual impairment in children. Further multi-centered studies are recommended to comprehensively understand pediatric refractive errors in Indonesia.
The use of Artificial Intelligence for Diagnosing Retinopathy of Prematurity – A Systematic Review Pertiwi, Adinda Mulya; Yulia, Dian Estu; Lestari, Yeni Dwi
International Journal of Retina Vol 8 No 2 (2025): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2025.vol008.iss002.316

Abstract

Purpose: Retinopathy of prematurity (ROP) is a vaso-proliferative disease of the retina associated with prematurity and is well known to be the leading cause of childhood blindness worldwide. Given the prevalence of ROP and the increasing demand for efficient screening solutions, this systematic review aims to update the current development of Artificial Intelligence (AI) technologies for ROP diagnosis and screening, considering the appropriate AI types that align with the specific needs and workloads of ROP screening programs. Methods: We performed a systematic literature review of the English online literature databases by applying a general search strategy on April 20, 2024. Search phrases included multiple variants of terms including "ROP", "retinopathy of prematurity", "artificial intelligence", "diagnosis", "sensitivity analysis", "specificity", "area under the curve". Findings: A total of 12 studies were identified from varied countries. Summary: Review of the published literature demonstrate high sensitivity across different studies, indicating their strong potential for early detection of ROP but demonstrating variability in specificity. The review also underscores the importance of domain adaptation and validation across diverse populations to ensure generalizability. AI integration in clinical practice, especially in telemedicine, can enhance early detection, standardize diagnoses, and alleviate the burden on healthcare professionals, particularly in low-resource settings.