Judian, Terence
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Keamanan Kranberi dalam Pencegahan Infeksi Saluran Kemih: Analisis Judian, Terence
Cermin Dunia Kedokteran Vol 52 No 3 (2025): Oftalmologi dan Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i3.1477

Abstract

Urinary tract infection is a common disease with high recurrence. UTI is usually treated with antibiotics, however high bacteria resistance towards first-line antibiotic treatment is becoming a health issue. Cranberries have been shown to prevent the adhesion of bacteria to host cell, hence preventing UTI. This systematic review aimed to determine the effectivity and safety of cranberry for prevention of urinary tract infection. Systematic Review was done with search engine from Google Scholar, PubMed, and ScienceDirect, starting with forming clinical question using PICO framework. Studies included was selected based on inclusion and exclusion criteria. The outcomes extracted from each study are the effectiveness and safety of cranberries in UTI prevention. Eight studies were reviewed, seven studies concluded that cranberries can significantlyprevent UTI, while 1 study found that the result was not significant. Three studies reported minimal adverse effect in a small percentage of patients. Cranberries can reduce the incidence of recurrent UTI with minimal adverse effect. PACs (proanthocyanidins) in cranberries can prevent bacteria adhesion, therefore preventing colonization of the bacteria in the urinary tract. Further research on dose and duration are required.
Tolvaptan untuk Hiponatremia Euvolemik dan Hipervolemik: Tinjauan Narasi Judian, Terence; Alexsander, Samuel
Cermin Dunia Kedokteran Vol 51 No 12 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i12.1498

Abstract

Hyponatremia is an electrolyte imbalance disorder commonly found in clinical practice. Hyponatremia is associated with significant mortality and morbidity. Tolvaptan is an orally administered V2 receptor antagonist drug capable of aquaresis without excreting electrolytes, thus increasing plasma sodium concentration. Results from clinical trials showed tolvaptan to be a relatively safe and effective treatment in euvolemia and hypervolemia hyponatremia.