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All Journal Jurnal Indonesia Sosial Sains Journal Research of Social Science, Economics, and Management
Kristanto, Andre
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Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Energy Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Neuroscience Physics Social Sciences

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Effects of Papaya (Carica Papaya) Leaf Extract on Collagen Synthesis Enhancement in Various Experimental Studies: Molecular and Histological Review Kristanto, Andre; Satriyasa, Bagus Komang; Artini , I Gusti Ayu
Jurnal Indonesia Sosial Sains Vol. 6 No. 8 (2025): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v6i8.1837

Abstract

Collagen synthesis plays an important role in tissue regeneration and the skin aging process. This process can be disrupted by oxidative stress as well as increased expression of matrix metalloproteinases (MMPs). Papaya (Carica papaya L.) leaf extract contains bioactive compounds such as quercetin, vitamin C, and papain, which have the potential to stimulate collagen synthesis. The aim of this review was to analyze experimental evidence related to the effects of papaya leaf extract on collagen synthesis through molecular and histological approaches. Literature searches were conducted through PubMed, Google Scholar, and MDPI databases using the keywords “papaya leaf extract,” Carica papaya, “collagen,” and “photoaging.” Five articles that met the inclusion criteria were analyzed. Papaya leaf extract has been shown to lower ROS levels, suppress MMP expression, and activate the TGF-β pathway. Histological results demonstrated increased expression of type I collagen and accelerated wound healing in animal models. The potential of papaya leaf extract as a topical anti-aging agent and regenerative therapy is considered promising. However, further research is needed to determine the optimal dose and evaluate long-term safety.
Molecular and Nutritional Review of Phenylketonuria: Implications for Clinical Management Kristanto, Andre
Journal Research of Social Science, Economics, and Management Vol. 5 No. 4 (2025): Journal Research of Social Science, Economics, and Management
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jrssem.v5i4.1189

Abstract

Phenylketonuria (PKU) is an inborn error of metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, which inhibits the conversion of phenylalanine to tyrosine and leads to the accumulation of toxic metabolites. This disorder leads to neurotransmitter deficits, neurological dysfunction, and systemic complications if not addressed early. The primary management of PKU is a lifelong low-phenylalanine diet supported by a phenylalanine-free formula, macronutrient and micronutrient regulation, and pharmacological therapy. Understanding the molecular basis, nutrition, and current therapies is crucial to optimize clinical management and prevent long-term neurodegenerative consequences in individuals with PKU.
Co-Authors Artini , I Gusti Ayu Bagus Komang Satriyasa