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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Serina Abdimas
Radiance, Shamyra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Physics Public Health Social Sciences

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Effects of Stem Cell Therapy on Keloid Treatment: A Literature Review Eric, Eric; Angeline , Maria Olivia; Layrenshia, Belinda; Kelvin, Kelvin; Rianto, Louis; Nainggolan, Nadya; Willyana, Cindy; Radiance, Shamyra; Putri, Rizka Saffana Alinda
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.3865

Abstract

Fibroblasts that produce excess collagen and growth factors play a role in the pathogenesis of keloid formation. In general, keloids are treated with intralesional corticosteroids alone or with a combination of other modalities, but the recurrence rate is still relatively high, so alternative treatments such as stem cells are being investigated, one of which is Mesenchymal Stem Cells (MSC), which have proven to be useful in healing keloids. Therefore, this literature review aims to discuss the effects of stem cell therapy in the treatment of keloids. In this literature review, 36 journals were used that discussed stem cell therapy in the treatment of keloids taken from various journal sources, namely Google Scholar, Pubmed, Medline, Ebsco, Hindawi, and Cochrane which were published within the last 10 years. According to the source, MSC is divided into 2 types, namely Adipose Mesenchymal Stem Cells (AMSC) and Bone Marrow Mesenchymal Stem Cells (BMMSC). In several studies, AMSC is known to reduce the expression of TGF-β1, COL-1, and COL-2 proteins, and has been shown to inhibit the proliferation of fibroblasts in keloid patients. Whereas in the BMMSC study that was applied with Hydroxybutyl chitosan (HBC) and Arg-Gly-Asp (RGD) hydrogels for 7 days, it was shown to significantly reduce nodular collagen fibers (p<0.05). Keloids occur due to excessive production of collagen and are influenced by various factors such as age, gender, skin color, and genetics. Stem cell therapy, such as MSC, has been proven in various studies to be an alternative treatment for keloids
PEMBERIAN TABLET TAMBAH DARAH SEBAGAI UPAYA PENCEGAHAN ANEMIA PADA REMAJA PUTRI Novendy; Radiance, Shamyra; Fransmanto, Fransiscus; Khatimah, Gita Khusnul
Jurnal Serina Abdimas Vol 1 No 2 (2023): Jurnal Serina Abdimas
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jsa.v1i2.26106

Abstract

According to research conducted in Indonesia, the frequency of anemia in young women ranges from 32.6% to 61.1%. The World Health Organization committed to halving the prevalence of anemia in women of childbearing age by 2025 during the 65th World Health Assembly, along with an action plan and global targets for maternal, infant, and child nutrition. In response to these recommendations, the government prioritized the distribution of iron supplements through school institutions to increase the prevention and control of anemia in adolescent girls and women reproductive age. Puskesmas Gembong conducted a survey in December 2022, and showed that 53% of junior high school students had anemia. The distribution of iron supplements has been done to lower the prevalence of anemia in Puskesmas Gembong working region. The evaluation of elevated hemoglobin level has not been completely done. Therefore, The Faculty of Medicine Universitas Tarumanagara health care team decided to measure the hemoglobin levels of students who had taken iron supplements. On 43 female students, the hemoglobin levels were measured. The measurement findings revealed a 1.01 gr/dL increase in hemoglobin levels. Additionally, 11 (25.6%) female students had hemoglobin levels that were back to normal. Hemoglobin levels have been able to rise when iron supplements were given to female students who had anemia. Therefore, it is recommended that these procedures continue, from screening through the distribution of iron supplements to individuals who require them. So that less young women in Indonesia would get anemia and will become healthier holistically. Prevalensi anemia pada remaja putri berdasarkan data dari berbagai penelitian di berbagai lokasi di Indonesia berkisar antara 32.4-61%. Badan Kesehatan Dunia dalam World Health Assembly ke-65 telah sepakat dan berkomitmen untuk dapat menurunkan setengah prevalensi kejadian anemia terutama pada wanita usia subur pada tahun 2025. Sebagai tindak lanjut dari kesepakatan tersebut, Indonesia melakukan upaya pencegahan dan penanggulangan anemia pada remaja putri dan wanita usia subur dengan pemberian tablet tambah darah melalui sekolah. Hasil survei Puskesmas Gembong bulan Desember 2022 mendapatkan sebanyak 53% siswi SMP-SMA mengalami anemia dari ringan hingga berat. Pemberian tablet tambah darah telah dilakukan untuk menurunkan angka kejadian anemia di wilayah kerja Puskesmas Gembong. Namun hasil penilaian peningkatan nilai hemoglobin belum sepenuhnya dilakukan. Maka dengan itu, tim bakti kesehatan Fakulatas Kedokteran Universitas Tarumanagara melakukan kegiatan bakti kesehatan berupa pengukurun kadar hemoglobin pada remaja putri yang telah mendapatkan tablet tambah darah. Pengukuran kadar hemoglobin dilakukan pada 43 orang siswi. Hasil pengukuran didapatkan adanya peningkatan kadar hemoglobin sebesar 1.01 gr/dL. Selain itu didapatkan sebanyak 11 (25,6%) siswi yang kadar hemoglobinnya kembali ke nilai normal. Tablet tambah darah yang diberikan pada siswi dengan anemia telah mampu meningkatkan nilai kadar hemoglobin. Maka dianjurkan kegiatan seperti tetap terus dilakukan mulai dengan kegiatan skrining hingga pemberian tablet tambah darah bagi mereka yang membutuhkan. Sehingga kasus kejadian anemia terutama pada remaja putri di Indonesia akan semakin berkurang dan remaja putri di Indonesia akan tumbuh semakin sehat.
Co-Authors Angeline , Maria Olivia Eric, Eric Fransmanto, Fransiscus Kelvin Kelvin Khatimah, Gita Khusnul Layrenshia, Belinda Nainggolan, Nadya Novendy Putri, Rizka Saffana Alinda Rianto, Louis Willyana, Cindy