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All Journal Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC)
Nur Anindhita Kurniawaty Wijaya
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Agriculture, Biological Sciences & Forestry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Edukasi Peningkatan Self Control Remaja (ESTAFET) Dalam Upaya Pencegahan Perilaku Seks Bebas Pada Siswa SMA Di Manado Larira, Dina Mariana; Adriani Natalia; Nur Anindhita Kurniawaty Wijaya
Jurnal Pengabdian Masyarakat Mandira Cendikia Vol. 3 No. 6 (2024)
Publisher : YAYASAN PENDIDIKAN MANDIRA CENDIKIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Seks pranikah merupakan salah satu dari jenis seks bebas yang sering dilakukan para remaja yang disebabkan karena keingintahuannya tentang hal baru, dan tidak bisa mengontrol nafsu sehingga melakukan tindakan-tindakan yang kurang terpuji dan diluar norma agama seperti melakukan seks bebas. Diantara perempuan dan pria yang telah melakukan hubungan seksual pra nikah, 59% perempuan dan 74% pria melaporkan mulai berhubungan seksual pertama kali pada umur 15-19 tahun. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukasi peningkatan self control remaja dalam upaya pencegahan perilaku seks bebas pada siswa SMA. Adapun mitra dari pengabdian masyarakat ini yaitu SMA Negeri 9 Manado dan SMA Negeri 2 Pineleng. Kegiatan pengabdian masyarakat ini dilakukan melalui memberikan edukasi tentang seks bebas dan pencegahannya kepada remaja. Hasil yang diperoleh dari kegiatan ini yaitu adanya peningkatan pengetahuan pada remaja yang dibuktikan dengan hasil dari posttest peserta. Hal ini menunjukkan peserta memahami tentang perilaku seks bebas dan cara pencegahannya.
Pengaruh Pemberian Ekstrak Daun Leilem (Clerodendrum Minahassae) terhadap Gambaran Histopatologik Hati Tikus Wistar (Rattus Norvegicus) yang Diinduksi Minuman Beralkohol Cap Tikus Andrea Abelia Hans; Nur Anindhita Kurniawaty Wijaya; Maria Kristianti Sambuaga
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v5i1.8062

Abstract

Excessive alcohol consumption, including traditional alcoholic beverages such as Cap Tikus (alcohol content ±45%) from North Sulawesi, can induce liver damage characterized by steatosis, inflammation, and necrosis. Leilem leaf (Clerodendrum minahassae) extract, rich in phenolic and flavonoid compounds, has potential hepatoprotective effects due to its antioxidant properties. To evaluate the effect of leilem leaf extract on the histopathological features of the liver in Wistar rats (Rattus norvegicus) induced by Cap Tikus alcoholic beverage. This experimental study used a post-test only control group design with 24 male Wistar rats divided into four groups: normal control, negative control (Cap Tikus 2.16 mL/day), treatment I (leilem extract 150 mg/kgBW + Cap Tikus), and treatment II (leilem extract 300 mg/kgBW + Cap Tikus). Treatments were administered orally for 14 days. Liver tissue was processed for histopathological examination using hematoxylin-eosin staining and observed under a light microscope. The negative control group showed significant steatosis and inflammatory cell infiltration. Treatment groups exhibited reduced steatosis and inflammation, along with increased hepatocyte regeneration. The higher dose (300 mg/kgBW) demonstrated greater hepatoprotective effects and more prominent regeneration compared to the lower dose (150 mg/kgBW). No necrosis or fibrosis was observed in any group. Leilem leaf extract exerts a hepatoprotective effect by suppressing inflammatory responses and enhancing hepatocyte regeneration in Wistar rats induced with Cap Tikus. The highest protective efficacy was observed with leilem leaf extract at 300 mg/kgBW.
Pengaruh Pemberian Ekstrak Daun Paku (Diplazium esculentum) terhadap Gambaran Histopatologik Aorta Tikus Wistar (Rattus norvegicus) yang diinduksi Diet Tinggi Lemak Jeremy Elim Janilauren Pantouw; Carla Felly Kairupan; Nur Anindhita Kurniawaty Wijaya
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v5i1.8069

Abstract

Atherosclerosis, as the leading cause of cardiovascular disease, can be triggered by a high-fat diet that causes hyperlipidemia. Fern leaves (Diplazium esculentum) contain various bioactive compounds (alkaloids, phenols, flavonoids, terpenoids) with antioxidant and anti-inflammatory potential, which are suspected to inhibit the formation of atherosclerotic lesions. This study aims to determine the effect of administering fern leaf extract on the histopathological features of the aorta in Wistar rats induced by a high-fat diet. This laboratory experimental study used 25 male Wistar rats divided into five groups: (A) normal control, (B) negative control (high-fat diet), (C) positive control (high-fat diet + simvastatin), (D) treatment I (high-fat diet + fern leaf extract 600 mg/kgBW), and (E) treatment II (high-fat diet + fern leaf extract 1200 mg/kgBW). The treatment was administered for 21 days. On the 22nd day, the aorta was taken and processed into histopathological preparations using Hematoxylin-Eosin (H&E) staining. The number of foam cells was counted at 400x magnification. Data were analyzed using the One-Way ANOVA test followed by the Tukey test. There were differences in the number of foam cells between groups. The post-hoc test showed a significant difference between group B (high-fat diet) and all other groups (p<0.001). There was no significant difference between group E (extract 1200 mg/kgBW) and group C (simvastatin) (p=0.783), nor between group D (extract 600 mg/kgBW) and group C (p=0.075). Fern leaf extract (Diplazium esculentum) is able to reduce the number of foam cells in the aorta of Wistar rats induced by a high-fat diet.
Co-Authors Adriani Natalia Andrea Abelia Hans Carla Felly Kairupan Jeremy Elim Janilauren Pantouw Larira, Dina Mariana Maria Kristianti Sambuaga