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All Journal Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES)
Carla Felly Kairupan
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Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Pemberian Ekstrak Bunga Pepaya (Carica papaya L.) terhadap Gambaran Histopatologik Aorta Tikus Wistar (Rattus norvegicus) yang Diinduksi Diet Tinggi Lemak Suci Apriani Ponamon; Maria Kristanti Sambuaga; Carla Felly Kairupan
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v5i1.8055

Abstract

A high-fat diet can cause hyperlipidemia, which is one of the main risk factors for atherosclerosis. Papaya flowers (Carica papaya L.) contain antioxidants that have the potential to inhibit the development of atherosclerotic lesions. This study aims to determine the effect of papaya flower extract on the histopathological features of the aorta of Wistar rats induced by a high-fat diet. The study design is a posttest only-trial group design. The study sample consisted of 25 male Wistar rats divided into 5 groups with treatment for 21 days. Group A received no treatment. Group B was given high-fat diet consisting of 3 mL of pork fat and 2 g of duck egg yolk. Group C was given high-fat diet and simvastatin 0.18 mg/200 gBW. Groups D and E were given high-fat diet and papaya flower extract 125 mg/kgBW and 250 mg/kgBW, respectively. The parameter used is the histopathological description of the aorta in the form of foam cell formation. The results showed that there were few foam cell in group A. Group B had many foam cells in the tunica intima and media of aorta. Group C, D and E showed a reduction in the number of foam cells. The administration of papaya flower extract (Carica papaya L.) was effective in inhibiting foam cell formation in the aorta of Wistar rats induced by a high-fat diet, with a better effect seen at a dose of 250 mg/kgBW, which was almost comparable to simvastatin.
Pengaruh Pemberian Ekstrak Daun Paku (Diplazium esculentum) terhadap Gambaran Histopatologik Aorta Tikus Wistar (Rattus norvegicus) yang diinduksi Diet Tinggi Lemak Jeremy Elim Janilauren Pantouw; Carla Felly Kairupan; Nur Anindhita Kurniawaty Wijaya
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v5i1.8069

Abstract

Atherosclerosis, as the leading cause of cardiovascular disease, can be triggered by a high-fat diet that causes hyperlipidemia. Fern leaves (Diplazium esculentum) contain various bioactive compounds (alkaloids, phenols, flavonoids, terpenoids) with antioxidant and anti-inflammatory potential, which are suspected to inhibit the formation of atherosclerotic lesions. This study aims to determine the effect of administering fern leaf extract on the histopathological features of the aorta in Wistar rats induced by a high-fat diet. This laboratory experimental study used 25 male Wistar rats divided into five groups: (A) normal control, (B) negative control (high-fat diet), (C) positive control (high-fat diet + simvastatin), (D) treatment I (high-fat diet + fern leaf extract 600 mg/kgBW), and (E) treatment II (high-fat diet + fern leaf extract 1200 mg/kgBW). The treatment was administered for 21 days. On the 22nd day, the aorta was taken and processed into histopathological preparations using Hematoxylin-Eosin (H&E) staining. The number of foam cells was counted at 400x magnification. Data were analyzed using the One-Way ANOVA test followed by the Tukey test. There were differences in the number of foam cells between groups. The post-hoc test showed a significant difference between group B (high-fat diet) and all other groups (p<0.001). There was no significant difference between group E (extract 1200 mg/kgBW) and group C (simvastatin) (p=0.783), nor between group D (extract 600 mg/kgBW) and group C (p=0.075). Fern leaf extract (Diplazium esculentum) is able to reduce the number of foam cells in the aorta of Wistar rats induced by a high-fat diet.
Co-Authors Jeremy Elim Janilauren Pantouw Maria Kristanti Sambuaga Nur Anindhita Kurniawaty Wijaya Suci Apriani Ponamon