Vaginal discharge is a reproductive health problem that often occurs in adolescents. Vaginal discharge usually smells bad, causes itching, discomfort and lack of confidence and anxiety so that it can interfere with the learning process. The boarding school environment has a high potential to cause pathological vaginal discharge due to the poor sanitary conditions of the boarding school environment such as the provision of clean water, sewage, garbage, and density of occupants so that it will affect the health status of students. The purpose of this activity is to improve the knowledge of adolescent reproductive health and skills of female students in genital hygiene and early detection of pathological vaginal discharge. The method of this activity is in the form of training which includes education, simulation, demonstration, discussion, and question and answer. The activities began with the preparation of SAP and contracts with the boarding school administrators, at the implementation stage starting with the administration of the pre-test questionnaire, followed by providing health education on reproductive health, physiological and pathological vaginal discharge, signs and symptoms of pathological vaginal discharge, complications of pathological vaginal discharge, prevention of pathological vaginal discharge, and genital hygiene. Then continued with simulations and demonstrations of genital hygiene, how to wash the genital area, types of underwear that can absorb sweat, and hygiene during menstruation, as well as vaginal pH tests. At the end of the activity the participants were asked to fill out a post test questionnaire. The results of the activity obtained an increase in knowledge and skills of santriwati in genital hygiene and early detection of pathological vaginal discharge from all participants in the category of poor knowledge to sufficient and good knowledge. The conclusion of this activity is the first step to improve the reproductive health status of female students in boarding schools through independent vaginal pH detection so that the boarding school clinic can intervene quickly to prevent pathological vaginal discharge or detection of a disease.