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The Efficacy of Channa Striata Extract Administration in Improving Albumin and Creatinine Levels in Sepsis Patients in the Intensive Care Unit Panggabean, Mathilda; Lubis, Andriamuri Primaputra; Irina, Rr. Sinta; Amelia, Rina
Indonesian Journal of Applied Research (IJAR) Vol. 5 No. 1 (2024): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v5i1.414

Abstract

Albumin levels in the blood are an indicator for assessing the severity of sepsis. In sepsis patients, administering albumin extract from Channa striata has better potential to replace Human Albumin by 20%. This study aims to determine the role of Channa striata extract (CSE) in improving albumin and creatinine in sepsis patients. This research is a quasi-experimental research with a pre-post-test design. Sepsis patients who meet the inclusion and exclusion criteria and sign the informed consent form will be divided into treatment and control groups. Both groups received the same therapy protocol, except for the treatment group, which will be given CSE at a dose of 5gr, three times a day, for five days. Albumin, creatinine, and SOFA score measurements will be taken before the treatment and on the 7th day. All data will be tabulated and analyzed using statistical software. This study consisted of 2 groups, with a sample size of 20 patients for each group. It was found that the mean age of the research sample was 56.1 + 11.8 years. In the treatment group, there was no decrease in albumin levels before and after (2.76 + 0.41 to 2.76 + 0.40), p=0.952. There was no significant difference in assessing creatinine levels before and after treatment, p>0.05. There was an increase in SOFA score before and after treatment in both groups, p<0.05. Channa striata extract is clinically significant for improving the condition of sepsis patients in the ICU.
Post-General Anesthesia Angioedema After General Anesthesia Panggabean, Mathilda; Solihat, Yutu
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 2, No 1 (2022): April 2022
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v2i1.59185

Abstract

Background: General anesthesia includes the administration of avariety medicines to patient/in/ fairly short/period. Numerous negative consequences can occur because of reaction from the drugs given, one example is anaphylaxis that may lead to death if not been recognized and handled quickly & promptly.Case Illustration: A sixty-seven years old male patient 152 cm 65 kg with multiple cholecystitis and obstructive jaundice, who was scheduled to undergo laparoscopic cholecystectomy. Patient had no records of allergy to medication and food. Family has no records to hypersensitive reactions or angioedema. At initial evaluation, blood pressure was 190/90 mmHg and hemoglobin 10,4 g/dL while the rest parameter was within normal limits. We given propofol and rocuronium to induce relaxation and facilitate intubation in surgery. Approximately 90 minutes after rocuronium injection, patient evolved angioedema across the face/area, tongue, and floor of the mouth. Patient also complained of not being able to talk. Soon after that, we give 10 mg of dexamethasone and 100 mg hydrocortisone to the patient. Within 60 minutes after hydrocortisone administration the patient shows/clinical improvement that marked by swelling began to decrease and the patient was able to speak again. Then we educate patient about angioedema and its alert.Conclusion: Anaphylaxis is a type of hypersensitivity response that take place to a particular allergen and mostly self-limited, but 11% of hypersensitive reaction require airway intervention. Most of anesthetic medication such as thiopental sodium, propofol, muscle relaxants, and etomidate may induce anaphylactic reaction during anesthesia induction. Discontinuation of underlying agent and airway control may prevent mortality and morbidity.