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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Sciences of Pharmacy
Huang, Ya-lin
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Health Professions Medicine & Pharmacology Public Health

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The Effect of Poloxamer 188 on the Solubility and Dissolution Behaviors of Piroxicam-PEG 4000 Solid Dispersions Yugatama, Adi; Azizah, Anas Muti'ah Syahrul; Choiri, Syaiful; Huang, Ya-lin
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404403

Abstract

Piroxicam (PRX), a non-steroidal anti-inflammatory drug (NSAID), is classified as a biopharmaceutical classification system class II (high permeability and low solubility), which limits its bioavailability. Enhancement of the dissolution rate is a key strategy to enhance the absorption. Solid dispersion systems, particularly when combined with amphiphilic multiple co-block polymers, offer a promising approach to address this challenge. This study aimed to investigate the effect of Poloxamer 188 (P188) and the solid dispersion technique on the solubility and dissolution rate of PRX. Polyethylene glycol (PEG) 4000-based solid dispersions containing PRX were prepared using varying concentrations of Poloxamer 188 surfactant through the fusion method. The solid dispersions were evaluated for saturated solubility in water for 24 hours. Selected formulations were further characterized using thermal analysis and vibrational spectroscopy. The optimized solid dispersion formulation was filled into capsules, and a dissolution assay was carried out to compare its performance with that of pure PRX capsules. The optimized formula, comprising 3% P188 and PEG4000, demonstrated a significant enhancement in saturation solubility parameters (p < 0.05), specifically the Cmax/S0 ratio. Additionally, dissolution testing showed a 22.22% increase in the dissolution rate of the PRX solid dispersion capsules compared to pure PRX capsules. In conclusion, P188-based solid dispersion containing PRX enhanced the solubility and dissolution rate, potentially improving therapeutic efficacy.
The Influence of Release Modifier Differences in Formulations on the Pharmacokinetic Profile of Ketoprofen in Rats: A Scoping Review Yugatama, Adi; SWM, Alyanis Mufid; Niruri, Rasmaya; Huang, Ya-Lin; Khoa, Nguyen Dang
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.80292

Abstract

The pharmacokinetic profile of drugs can be changed by genetic, environmental, and physiological variables such as age, sex, pregnancy, and different preparations and formulations. Ketoprofen is widely used in many different preparations and formulations. The various formulations can made by adding solubilizing and extending release agents. This study aimed to determine the influence of formulation differences on the pharmacokinetic profile of ketoprofen in rats. This research was a Literature Review. Articles were retrieved from the ScienceDirect and PubMed databases from 2011 to 2020. The inclusion criteria were the research article, the presence of ketoprofen was formulated with the addition of a solubilizing or extended-release agent, given orally and available in open access. The study resulted in differences in formulation, notably the addition of various dissolving agents or extended-release agents, which caused changes in the pharmacokinetic profile of ketoprofen. The highest increase in the pharmacokinetic parameters Cmax and AUC of ketoprofen was observed with poloxamer-188 as a release modifier agent. Therefore, the use of release modifier agents could have a significant effect on the drug's pharmacokinetic profile.
Co-Authors Azizah, Anas Muti'ah Syahrul Khoa, Nguyen Dang Rasmaya Niruri SWM, Alyanis Mufid Syaiful Choiri