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All Journal Dental Journal (Majalah Kedokteran Gigi)
Salsabila, Dinda Aprilla
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Dentistry

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The potential active compounds of Jatropha multifida Linn. as an anti-COVID-19 mouthwash: In silico study Effendi, Muhammad Chair; 'Ayun, Aisyah Fitri Qurrata; Putri, Annisa; Kurniawan, Dhiky Dwi; Salsabila, Dinda Aprilla; Malihahsisna, Fahrunisa Tunjung
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 2 (2024): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i2.p110-117

Abstract

Background: Povidone-iodine 1% mouthwash is one of the products recommended for preventing and controlling COVID-19 infection in dental procedures. Jatropha multifida Linn. has the same antiseptic effect as povidone-iodine. Purpose: The objective is to determine the effectiveness and interaction effect of secondary metabolites from the latex of Jatropha multifida Linn. and povidone-iodine against the main protease (MPro) SARS-CoV-2 and the SARS-CoV-2 spike protein - ACE2 receptors. Methods: The in silico test was used in this study and carried out using the Molegro Virtual Docker software for molecular docking and BIOVIA Discovery Studio and PyMOL for visualization. Results: The results show that secondary metabolite compounds contained in the latex of Jatropha multifida Linn. have a better effectiveness potential in relation to MPro SARS-CoV-2 and SARS-CoV-2 spike protein - ACE2 receptors than povidone-iodine. Conclusion: The latex of Jatropha multifida Linn. shows potential as a preventive and curative therapy for COVID-19 in the in silico study.
Co-Authors 'Ayun, Aisyah Fitri Qurrata Annisa Putri Effendi, Muhammad Chair Kurniawan, Dhiky Dwi Malihahsisna, Fahrunisa Tunjung