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Ibtisam, Afina Anjani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Physics

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Bioactivity mapping of secondary metabolite compounds of Pandanus amaryllifolius leaves as anti-inflammatory using in silico Arrohmah, Robiatus Sholichah; Ibtisam, Afina Anjani; Sa’adah, Siti Malihatus; Putri, Fensy Rania; Fitriyah, Fitriyah
Journal of Natural Sciences and Mathematics Research Vol. 9 No. 1 (2023): June
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

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Inflammation is one of the primary responses of the immune system to infection and irritation. Anti-inflammatory drugs generally cause side effects. Anti-inflammatory developed by reducing side effects use many natural materials such as plants. The parts of the plant used include fruits, leaves, stem bark, rhizomes, and flowers. One of the plants that can be used as an anti-inflammatory is Pandanus amaryllifolius. P. amaryllifolius leaves contain several materials, such as flavonoids, alkaloids, saponins, tannins, polyphenols, and dyes. This study aimed to determine the anti-inflammatory potential of the secondary metabolites of Pandanus amaryllifolius leaves using the in silico method. The research used a descriptive exploratory method and was conducted from December 2022 – January 2023. In silico mapping of the bioactivity of active compounds was carried out using several software or websites: knapsack database (www.knapsackfamily.com), NCBI PubChem database (https://pubchem.ncbi.nlm.nih.gov/), PASS Online Way 2 Drug (http://www.way2drug.com/passonline/) and ADME Swiss Analysis (http://www.swissadme.ch/). The result shows P. amarylifolius has 31 active compounds. The compounds were then analyzed using Pass Online with 18 anti-inflammatory parameters. It explained that 3 compounds met the rules for Pa values > 0.7, namely compounds 6E-Pandanamine (0.758), Pandamenyamine (0.735), and Pandamarilactone 1 (0.709). The results of pharmacokinetic tests using Lipinski
Phytochemical analysis of secondary metabolite compounds of Pandanwangi leaf extract (Pandanus amaryllifolius) Sa'adah, Siti Malihatus; Putri, Fensy Rania; Ibtisam, Afina Anjani; Arrohmah, Robiatush Sholichah; Fitriyah, Fitriyah
Journal of Natural Sciences and Mathematics Research Vol. 9 No. 2 (2023): December
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

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The majority of people use pandan as a dye, food fragrance, and natural medicine because it contains secondary metabolites such as alkaloids, saponins, and phenolics. Therefore, this research aims to explore the secondary metabolites of Pandanus amaryllifolius using qualitative and quantitative methods. The research begins by taking samples of pandan leaves, which are then extracted and tested qualitatively and quantitatively. The qualitative test results showed that pandan leaf extract contained flavonoids, polyphenols, and tannins. In the quantitative test of pandan leaf phenolic compounds using a UV-Vis spectrometer with gallic acid concentrations of 80 ppm, 100 ppm, 120 ppm, and 140 ppm, Based on the quantitative test, the total phenolic content of pandan extract is 114 mg/L.
Co-Authors Arrohmah, Robiatus Sholichah Arrohmah, Robiatush Sholichah Fitriyah Fitriyah Putri, Fensy Rania Sa'adah, Siti Malihatus Sa’adah, Siti Malihatus