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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International Journal of Technology and Education Research
K. Salimi, Yuszda
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Decision Sciences, Operations Research & Management Education Languange, Linguistic, Communication & Media Medicine & Pharmacology Other

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Student Concept Mastery and Scientific Literacy Profile on Redox Concepts in Senior High Schools in North Gorontalo S. Gani, Melinda; Lukum, Astin; Pikoli, Masrid; A.R. Laliyo, Lukman; K. Salimi, Yuszda; La Kilo, Akram
International Journal of Technology and Education Research Vol. 3 No. 04 (2025): October - December, International Journal of Technology and Education Research
Publisher : International journal of technology and education research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63922/ijeter.v3i04.2460

Abstract

This study analyzed the profiles of students’ concept mastery and scientific literacy on the topic of reduction-oxidation (redox) reactions in three senior high schools in North Gorontalo, Indonesia. A descriptive qualitative approach was employed, involving written tests and interviews with 12th-grade students at SMAN 1, SMAN 3, and SMAN 6 North Gorontalo. The test instruments were designed based on the revised Bloom’s Taxonomy cognitive levels (C1–C6) and Programme for International Student Assessment (PISA) scientific literacy dimensions (context, content, competence, attitude). Results indicate that students have moderate overall concept mastery, with highest performance on lower-order cognitive skills remembering (C1) and understanding (C2) but substantially lower performance on higher-order skills such as applying (C3), analyzing (C4), evaluating (C5), and creating (C6). In terms of scientific literacy, students performed best in the content knowledge dimension, while showing weaknesses in scientific attitudes. Specifically, around 59% of students could recall basic facts (C1), but only ~35% could tackle creation-based tasks (C6). Likewise, over 54% demonstrated understanding of scientific content, yet less than 47% exhibited strong scientific competencies or attitudes. These findings suggest that current teaching practices heavily emphasize rote learning of content, leading to decent factual knowledge but insufficient higher-order thinking and lack of engagement with science in real-life contexts. The study highlights the need for instructional innovations such as inquiry-based, problem-based, and context-oriented learning to strengthen students’ conceptual understanding at all cognitive levels and to foster scientific skills and attitudes.
IDENTIFIKASI TURUNAN ASAM KARBOKSILAT AKAR Acalypha indica SEBAGAI KANDIDAT INHIBITOR GFAT MELALUI LC-HRMS DAN STUDI IN SILICO Arviani; K. Salimi, Yuszda; Bialangi, Nurhayati; Chandra Lakasan, Ahmad; Nur Rahman, Zifran
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2828

Abstract

Diabetes mellitus remains a major global health challenge, prompting the exploration of natural products as sources of safer antidiabetic agents. This study aimed to identify bioactive compounds from the roots of Acalypha indica and evaluate their potential as inhibitors of glutamine–fructose-6-phosphate amidotransferase (GFAT), an enzyme involved in glucose metabolism. Compound profiling was conducted using liquid chromatography–high resolution mass spectrometry (LC-HRMS), while the inhibitory potential against GFAT was assessed through in silico docking. This integrated approach has not been previously reported. Metabolite profiling using LC-HRMS tentatively identified thirteen carboxylic acid derivatives, including hydroxycinnamic acid, gluconic acid, trans-aconitic acid, and glucoheptonic acid. molecular docking analysis revealed strong binding affinities of several compounds toward GFAT.  Glucoheptonic acid exhibited the lowest binding energy (−8.0 kcal/mol), followed by xylaric acid A (−7.9 kcal/mol) and trans-aconitic acid (−7.5 kcal/mol). These compounds interacted with key active-site residues Gln421, Ser420, Ser422, and Lys675, suggesting a potential enzyme inhibition mechanism. In silico pharmacokinetic analysis indicated that 2-hexylpentanedioic acid exhibited favorable ADME properties, with high gastrointestinal absorption, no major inhibition of CYP450, and low predicted acute toxicity risk. These findings highlight Acalypha indica roots as a promising source of bioactive carboxylic acid derivatives, with glucoheptonic acid emerging as the most promising candidate for further in vitro evaluation as a GFAT inhibitor
Co-Authors Akram La Kilo Arviani Astin Lukum Chandra Lakasan, Ahmad Lukman A. R. Laliyo Masrid Pikoli Nur Rahman, Zifran Nurhayati Bialangi S. Gani, Melinda