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SAUDALE, FREDY Z.
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science

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FFAR4/GPR120 SEBAGAI TARGET DESAIN DAN PENGEMBANGAN OBAT DIABETES MELITUS TIPE 2 IN SILICO: SUATU TINJAUAN DAN PERSPEKTIF SAUDALE, FREDY Z.; TOKAN, MERVINA B.; LEO, STEVEN Y.; ATI, SERLY P.
Chemistry Notes Vol 2 No 1 (2020): Chem. Notes 2020, 2(1)
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cn.v2i1.2338

Abstract

FFAR4/GPR120 is an attractive membrane protein for diabetic drug design. Crystal structure of GPCR membrane proteins is difficult to obtain. Most of GPCR proteins lack experimental 3D structures. Therefore, computational method (in silico) using comparative homology modelling has been widely applied to solve it. To develop FFAR4/GPR120 selective compounds with high specificity, homology modelling of FFAR4/GPR120 can be constructed by utilizing other known GPCR crystal structures. This review article surveys the recent developments in the application of computational approaches in searching for selective agonist ligands and provides a perspective on computational approaches to the development of new drugs targeting FFAR4/GPR120.
BIOKIMIA DI ERA BIG DATA GENOMIK: TANTANGAN, APLIKASI DAN PELUANG INOVASI Saudale, Fredy Z.
Chemistry Notes Vol 2 No 2 (2020): Chem. Notes 2020, 2(2)
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cn.v2i2.3270

Abstract

The completion of human genome project at beginning of 21st century with the advancement of computer technology has transformed Biochemistry into a genomic era. Further, it is accelerated by parallel and massive genome sequencing technology known as next generation sequencing (NGS) that enhances the identification of genetic variants associated with complex diseases such as cancer, diabetes and Alzheimer. Currently, this knowledge has been driving the development of precision and personalized medicine. Wisely applied, it is believed that the explosion of genomic big data can be of great use in advancing the diagnosis, therapy and drug discovery to combat complex diseases.
Synthesis and Characterization of Zeolite from Refractory Brick Waste Selan, Odi Th. E.; Hema, Maria D.; Saudale, Fredy Z.; Suwari, Suwari
Chemistry Notes Vol 3 No (1) (2021): Chem. Notes 2021, 3(1)
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cn.v3i(1).4733

Abstract

The synthesis of zeolite from refractory brick waste using hydrothermal technique had been conducted. Two different reactans, NaOH and Mg(OH)2, were separately employed to react with SiO2 and Al2O3 from brick sample to produce metal silicate and metal aluminate which were then reacted to obtain zeolite. XRF results show that the synthesized products using both reactants have Si/Al ratios between 1-1.5 considered as low type of zeolites regardless some remaining impurities. XRD data reveal a typical pattern of zeolite with 2 Ɵ angles of 15.91; 19.52; 25.47; 32.20; 35.54 and 41.54. The IR vibration characteristic of Si-O and Al-O bonds appears in 454 cm-1 while the symmetric and asymmetric stretching vibrations of these two bonds absorb around 679.66 – 778.02 cm-1 and 2033.96-1092.42 cm-1, respectively. The O-H group from Si-OH associated with the formation of zeolite gives a characteristic feature at 3618 cm-1. SEM analysis also shows similar morphological features with natrolite zeolite. The use of NaOH as reactant gives more zeolite product compared to Mg(OH)2 reactant.
Co-Authors ATI, SERLY P. Hema, Maria D. LEO, STEVEN Y. Selan, Odi Th. E. Suwari Suwari TOKAN, MERVINA B.