<![CDATA[Background: Leaves are a plant that is widely used and widely cultivated throughout Indonesia, and has the potential as a traditional medicinal plant that is beneficial for the health of the body. Bangun-bangun leaves have been investigated and are known to contain compounds that are thought to have antibacterial activity, namely flavonoids, and tannins. The bacteria used to test the antibacterial ability of the leaves was Propionibacterium acnes. Objective: The purpose of this study was to determine the antibacterial activity of the ethanolic extract of the leaves of Bangun-bangun against Propionibacterium acnes bacteria. Method: The process of making extracts of the leaves of Bangun-bangun using the maceration method with 96% ethanol as a solvent. The macerate was evaporated until a thick extract of the leaves was obtained. The simplicial powder was characterized and screened for phytochemicals. The concentration treatment groups used were 1%, 2%, and 3%. The test was carried out by the agar diffusion method against the test bacteria using a paper backer, the results were observed in the form of a zone of inhibition and the value of the Minimum Inhibitory Concentration (MIC) was determined. Results: Results Characterization of simplicial powder, including water content, water-soluble extract content, ethanol soluble extract content, total ash content, and acid insoluble ash content were as follows: 7.99%, 24,24%, 24,02%,5,82,%, and 1.24%. The results of the screening of Simplicial powder were positive for containing alkaloids, flavonoids, glycosides, saponins, tannins, and steroids/triterpenoids. The results showed that the ethanol extract of the leaves of Bangun-bangun had an antibacterial activity with the MIC value of the ethanolic extract of the leaves of Bangun-bangun against Propionibacterium acnes at concentrations of 1%, 2%, and 3%, respectively. Conclusion: The ethanolic extract of the leaves of Bangun-bangun has very strong activity as an antibacterial.]]>
