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All Journal SENTRI: Jurnal Riset Ilmiah Berita Biologi
Saputra, Yosi Dwi
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice

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POTENSI PRODUK ALAMI LAUT DARI EKSTRAK ETANOL Sargassum duplicatum DAN Padina australis SECARA SITOTOKSIK TERHADAP SEL HeLa Saputra, Yosi Dwi; Widiastuti, Endang Linirin; Berliana, Melisa Intan; Nurcahyani, Nuning
Berita Biologi Vol 23 No 1 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2024.661

Abstract

Salah satu penyebab utama kematian wanita Indonesia adalah kanker serviks. Pertumbuhan sel jaringan tubuh yang tidak terkendali yang berubah menjadi tumor adalah akar penyebab penyakit ini. Banyak peneliti sedang menyelidiki beragam bahan kimia alami dari habitat laut sebagai pilihan pengobatan antikanker karena pengobatan kanker serviks memiliki efek samping yang besar dan durasi pengobatan yang panjang. Makroalga merupakan salah satu organisme laut yang dapat berpotensi sebagai sumber obat alami untuk terapi kanker. Bahan aktif seperti flavonoid, alkaloid, saponin dan steroid berpotensi sebagai agen anti kanker yang diduga dapat mempengaruhi siklus sel dalam pertumbuhan kanker melalui mekanisme apoptosis. Penelitian ini bertujuan untuk menganalisis pengaruh senyawa bioaktif yang terkandung didalam ekstrak Sargassum duplicatum dan Padina australis terhadap sitotoksisitas sel kanker serviks, HeLa. Aktivitas sitotoksik terhadap sel HeLa dievaluasi dengan menggunakan metode WST-8 dengan variasi kosentrasi ekstrak etanol 62,5; 125; 250; 500; 1.000; dan 2.000 ppm. Hasil uji sitotoksik memperlihatkan bahwa ekstrak S. duplicatum dan P. australis memiliki aktivitas sitotoksik terhadap sel HeLa. Nilai IC50 Sargassum duplicatum dan Padina australis terhadap sel HeLa masing-masing sebesar 1.108,7 dan 681,1 μg/ml. Hasil penelitian mengindikasikan bahwa S. duplicatum dan P. australis mempunyai aktivitas sitotoksik melawan sel HeLa, sehingga dapat dijadikan sumber obat antikanker serviks.
Aktivitas Makroalga sebagai Agen Antikanker Serviks Saputra, Yosi Dwi
SENTRI: Jurnal Riset Ilmiah Vol. 4 No. 12 (2025): SENTRI : Jurnal Riset Ilmiah, Desember 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v4i12.5273

Abstract

One of the causes of death in the world is cancer. This situation is caused by the excessive development of body tissue cells that become tumors. Over the past few years, significant progress has been made in reducing cases and deaths from cervical cancer through prevention and treatment strategies. Macroalgae are marine organisms that can be used as a source of natural medicine to eradicate cancer. Active ingredients such as flavonoids, alkaloids, tannins, triterpenoids, polyphenols and steroids can act as anti-cancer agents. Genes found in macroalgae such as Bcl2 and p53 can influence the cell cycle in cancer growth. The purpose of this paper is to analyze the cytotoxic content as well as to test the phytochemical, anticancer activity and determine its potential as an anti-cancer agent which is widespread in Indonesian waters. The compilation of this bibliographic search used secondary research methods by collecting research topic data from various non-electronic and electronic libraries. The results of the review were obtained from several journals: the mechanism of antineoplastic agents against viruses and the cytotoxic activity of macroalgae against HeLa cells. Large algae have a cytotoxic action that can reject HeLa cells, so they can be used as variations in the production of cervical anticancer drugs. In the Indonesian seas, large algae grow abundantly and are used as medicinal ingredients to reduce the number of deaths from tumors.
Co-Authors Berliana, Melisa Intan Nuning Nurcahyani Widiastuti, Endang Linirin