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All Journal Journal Of World Science Indonesian Health Journal
Puspanadi, Theresa
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Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Can't be Overlooked: A Case Report of Pansinusitis Causing a Rare and Life-Threatening Cavernous Sinus Thrombosis Puspanadi, Theresa; Sugianto, Paulus; Limantara, Edward; Metaputra, Teguh Filbert
Journal of World Science Vol. 4 No. 11 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i11.1536

Abstract

Sinusitis is a prevalent, mostly favorable medical condition. However, in rare cases, inadequately treated sinusitis can lead to devastating and life-threatening complications, such as cavernous sinus thrombosis (CST). We present the case of a 41-year-old woman presenting with diplopia and ophthalmoplegia, ptosis, facial paresthesia, and less common facial paresis. Diagnostic imaging–including magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), and digital subtraction angiography (DSA) confirmed bilateral CST secondary to untreated pansinusitis. Cultures of sinus drainage revealed uncommon pathogens: Staphylococcus epidermidis and Chryseobacterium indologenes. A multidisciplinary approach involving intravenous antibiotics, anticoagulation, and functional endoscopic sinus surgery (FESS) resulted in significant clinical improvement. This case highlights the critical need for accurate diagnosis, timely and prudent intervention, and enhanced public health education to prevent potentially life-threatening complications of untreated sinusitis. Moreover, it contributes novel insights into the atypical microbiological profile and neurological manifestations of CST.
A New Strategy for Presbycusis: A Literature Review on Stem Cell Thera-Py for Hair Cell and Auditory Neuron Regeneration Puspanadi, Theresa; Sugianto, Paulus; Limantara, Edward; Metaputra , Teguh Filbert
Indonesian Health Journal Vol. 4 No. 4 (2025): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v4i4.787

Abstract

Presbycusis, or age-related hearing loss, is the leading cause of hearing loss among the elderly, leading to decreased quality of life and mental health issues. While existing treatments offer some benefits, they have limitations and do not address the degenerative nature of presbycusis. This literature review examines the regenerative potential of stem cell therapy and its derivatives for cochlear hair cells and auditory neurons in cases of presbycusis. A search was conducted across PubMed, ScienceDirect, and Google Scholar to identify literature published from 2020 to 2025 that studied stem cells and their derivatives for hair cell and auditory neuron regeneration in presbycusis models. Three preclinical studies using bone marrow-derived mesenchymal stem cells (MSCs) in rodent models demonstrated the regeneration of hair cells and auditory neurons, with evidence of hearing improvement. Each study employed unique MSC modifications using advanced techniques, such as gene editing and extracellular vesicle derivation, to enhance anti-inflammatory and antiapoptotic properties. Stem cell-based therapies for presbycusis show promise but remain in early developmental stages. Major challenges include optimizing delivery methods (intracochlear, intratympanic, or intravenous routes), ensuring long-term safety profiles, preventing immune rejection and tumorigenicity, establishing standardized protocols for cell preparation and dosing, and addressing high treatment costs. Further clinical and local research is essential to facilitate the implementation of this therapy in Indonesia.
Co-Authors Limantara, Edward Metaputra , Teguh Filbert Metaputra, Teguh Filbert Paulus Sugianto, Paulus