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Studi Penggunaan Natrium Valproat Kurang Dari Tiga Bulan Terhadap Magnesium Serum Dan Jumlah Kejang Pasien Epilepsi Di RSUD Dr. Soetomo Latuasan, Ivana Rahayu; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Epilepsy is a brain disorder characterized by a tendency to cause continuous epilepsy attacks with neurobiological, cognitive, psychological and social consequences. The appearance of temporary signs or symptoms is caused by abnormal and excessive neuron activity in the brain. Sodium valproate can be used as epilepsy therapy because it is effective in inhibiting seizures, partial seizures, and tonic-clonic seizures. The mechanism of action of sodium valproate in the treatment of epilepsy is to increase the inactivation of Na + channels, thereby reducing the nerve's ability to transmit electric charges. Magnesium is a potential modulator of seizure activity because of its ability to inhibit excitation through N-methyl D-aspartate receptors. The aim of this study was to determine serum magnesium levels with sodium valproate treatment and the number of seizures as well as to identify drug-related problems in epilepsy patients who were less than three months old. The research was conducted in the Electroencephalography Room of the Regional Hospital Dr. Soetomo Surabaya by using observational methods in the form of prospective studies using data collection sheets and questionnaires. Samples were taken from July 1 to September 30, 2017. Based on laboratory results, the average magnesium content of patients with seizures was 2.22 mg / dL while non-seizure patients were 2.08 mg / dL. The conclusion of this study is that the use of sodium valproate does not affect magnesium levels in epilepsy patients and epilepsy patients who get sodium valproate therapy have a lower risk of seizures than those who do not get sodium valproate medication.

Studi Penggunaan Obat Phenytoin Kurang dari Tiga Bulan terhadap Kadar Magnesium Serum dan Jumlah Kejang Pasien Epilepsi di RSUD DR. Soetomo Surabaya Sanjiwani, Kadek Siska Febri; Sugianto, Paulus; Kasih, Elisabeth
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Epilepsy is a clinical phenomenon associated with an electrical explosion or excessive abnormal depolarization, which occurs in focus in the brain which causes a paroxysmal awakening. One of the anti-epilepsy drugs is phenytoin which belongs to the hydantoin class. This study aims to describe the serum Mg levels in epilepsy patients with phenytoin drug therapy in Dr. Soetomo General Hospital with a treatment period of less than three months and to identify DRP problems (Drug Related Problems). The method used in this study is prospectively presented by descriptive method (observational). The population in this study were epilepsy patients who were treated at the RSUD dr. Soetomo Surabaya with a sample of 28 epilepsy patients treated at the Outpatient and EEG Neurology Room at Dr. Soetomo General Hospital Surabaya. Results showed that Mg2+ levels in 28 patients with the highest magnesium levels were 2.46 mg / dL. While the lowest magnesium content is 1.78 mg / dL. Conclusions Patients' magnesium levels are still within the normal range but it has not been concluded that phenytoin can increase serum Mg2+ levels and there is no significant difference between phenytoin therapy in epilepsy patients

Accuracy of Meningitis Bacterial Score (MBS) as an indicator in establishing the diagnosis of acute bacterial meningitis in adults Palupi, Imas R.; Sugianto, Paulus
Narra J Vol. 1 No. 3 (2021): December 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v1i3.66

Bacterial meningitis persists as a worldwide threat contributing to high mortality and morbidity rate, where differentiating bacterial meningitis from aseptic meningitis is key for better management and outcomes. Hence, this study aimed to assess the Bacterial Meningeal Score (BMS) as a tool for early diagnosis of acute bacterial meningitis. This study employed a retrospective cross-sectional method using medical records of patients with meningitis and meningoencephalitis who were hospitalized at Dr. Soetomo Hospital, from January 2018 to September 2021. Data of demographics, clinical, laboratory and cerebrospinal fluid (CSF) profile and culture were collected. The diagnostic performance of the BMS in diagnosing acute bacterial meningitis was evaluated by its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR +) and negative likelihood ratio (LR -). A total of 128 patients who had been diagnosed with meningitis and meningoencephalitis were included. Out of total patients, 53 samples were diagnosed with acute bacterial meningitis as confirmed by CSF culture. The sensitivity and specificity of BMS with cutoff >2.5 in diagnosing acute bacterial meningitis were 92.4% and 92.0%, respectively with PPV 89.1% and NPV 94.5%. The area under the curve (AUC) of BMS in diagnosing of acute bacterial meningitis was 95.6% (95%CI: 92.3%, 99%). A BMS score of greater than 2.5 indicates a high likelihood of acute bacterial meningitis, whereas a score less than 2.5 indicates a low likelihood.

Theologia dan pekerjaan: Bekerja dalam perspektif Alkitab dan relevansinya terhadap pelayanan Simanjuntak, Erwin Sudarmono; Paat, Vicky B.G.D; Sugianto, Paulus
Davar : Jurnal Teologi Vol 4, No 2 (2023): Desember
Publisher : Sekola Tinggi Teologi Sangkakala Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55807/davar.v4i2.149

ABSTRACTPeople spend most of their lives at work. Whether it's working as a profession or in spiritual service. However, many people think that work as a profession is very different or has a very large gap before God from work in the ministry. There are those who interpret working as a profession as a matter outside of God and worldly in nature. There are also those who interpret work as a profession as completely worldly affairs and not God's calling. Through research into the Bible, it is hoped that the right attitude for humans to view their work will be found, so that humans can interpret their work positively and productively. The results of Bible studies show that work is an activity that is intrinsic to humans as a creation in which God, the creator is also depicted as a figure who works. The purpose of this research is to find out the relevance of work to service, so that everyone realizes the attitude of a calling to work in the midst of the world of work towards mission and service. The research method used was collecting literature to solve problems so that the results were found that working as a profession is a calling from God and has strong relevance to service. Keywords: Work, Relevance, Service ABSTRAKKehidupan orang sebagian besar hidupnya menghabiskan waktu dalam pekerjaan. Baik itu bekerja sebagai profesi maupun dalam pelayanan kerohanian. Namun banyak orang menganggap bahwa pekerjaan sebagai profesi itu sangat berbeda jauh atau punya kesenjangan yang sangat jauh dihadapan Tuhan dengan pekerjaan dalam pelayanan. Ada yang memaknai bahwa bekerja sebagai profesi sebagai urusan diluar Tuhan dan bersifat duniawi. Ada juga yang memaknai bekerja sebagai profesi itu seutuhnya adlah urusan-urusan dunia dan bukan panggilan Tuhan. Melalui penelitian terhadap Alkitab, diharapkan ditemukan sikap yang tepat bagi manusia untuk melihat pekerjaannya, sehingga manusia bisa memaknai pekerjannya secara positif dan produktif. Hasil kajian Alkitab menunjukkan bahwa bekerja adalah aktivitas yang melekat kepada manusia secara hakiki sebagai suatu ciptaan di mana Allah, sang pencipta juga digambarkan sebagai sosok yang bekerja. Tujuan penelitian ini adalah untuk menemukan apa relevansi pekerjaan terhadap pelayanan, sehingga setiap orang mewujudkan sikap panggilan bekerja ditengah-tengah dunia pekerjaan terhadap pelayanan misi maupun pelayanan. Metode penelitian yang dipakai dengan mengumpulkan literatur untuk memecahkan masalah sehingga menemukan hasil bahwa bekerja sebagai profesi merupakan panggilan dari Tuhan dan memiliki relevansi yang kuat terhadap pelayanan. Kata kunci: Pekerjaan, Relevansi, Pelayanan

Remaja di era modern: perspektif dan strategi pastoral Sugianto, Paulus; David, Bryan; Susana, Mulyani; Stepanus, Stepanus
Davar : Jurnal Teologi Vol 5, No 1 (2024): Juni
Publisher : Sekola Tinggi Teologi Sangkakala Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55807/davar.v5i1.155

ABSTRACTAdolescence is a turbulent transition period, where individuals experience significant changes in mental, emotional, social, and physical aspects. During this period, adolescents often face various problems, both caused by their own actions and by external conditions such as parental divorce. In Indonesia, common moral crises include honesty, responsibility, and discipline. Education from parents, schools, and churches plays a crucial role in accompanying adolescents. This study uses a descriptive qualitative approach with data collection through interviews with adolescent mentors and literature reviews. This method aims to provide an in-depth and holistic picture of the phenomenon being studied, with researchers as the main instrument in obtaining the necessary data. The church has a responsibility to disciple each of its members, including the younger generation and adolescents. The church must be more proactive in implementing a discipleship-based curriculum and understanding the developmental needs of adolescents. Keywords: Adolescents, Modern era, Perspective, Strategy, Pastoral. ABSTRAKMasa remaja merupakan periode transisi yang penuh gejolak, di mana individu mengalami perubahan signifikan dalam aspek mental, emosional, sosial, dan fisik. Selama masa ini, remaja sering menghadapi berbagai permasalahan, baik yang disebabkan oleh tindakan mereka sendiri maupun oleh kondisi eksternal seperti perceraian orang tua. Di Indonesia, krisis moral yang umum meliputi kejujuran, tanggung jawab, dan disiplin. Pendidikan dari orang tua, sekolah, dan gereja memainkan peran krusial dalam mendampingi remaja. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan pengumpulan data melalui wawancara dengan pembina remaja dan kajian literatur. Metode ini bertujuan untuk memberikan gambaran mendalam dan holistik tentang fenomena yang diteliti, dengan peneliti sebagai instrumen utama dalam memperoleh data yang diperlukan. Gereja memiliki tanggung jawab untuk memuridkan setiap anggotanya, termasuk generasi muda dan remaja. Gereja harus lebih proaktif dalam menerapkan kurikulum berbasis pemuridan dan memahami kebutuhan perkembangan remaja. Kata Kunci: Remaja, Era modern, Perspektif, Strategi, Pastoral.

MLC 901 Decreases HSP-70, MMP-9, Cerebral Infarction Volume and Functional Outcome in Acute Ischemic Stroke Rat Model Hunaifi, Ilsa; Bintang, Andi Kurnia; Tammasse, Jumraini; Wahid, Isra'; Hatta, Mohammad; Islam, Andi Asadul; Zainuddin, Andi Alfian; Sugianto, Paulus
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3610

BACKGROUND: Acute ischemic stroke (AIS) is usually treated with thrombolysis, however the percentage of patients receiving this therapy is not quite low. Therefore, it is necessary to find alternative therapy using neuroprotective agent such as Moleac (MLC) 901. Heat shock proteins (HSP)-70 and matrix metalloproteinase (MMP)-9 are usually related to AIS due to the triggered stroke-induced physiological stress. However, the effect of MLC 901 on Hsp70 mRNA expression, HSP-70 and MMP-9 remains unclear. This study was conducted to determine the effect of MLC 901 on those three parameters in relation to cerebral infarction volume and functional outcomes in an AIS model.METHODS: Rats were induced with AIS using unilateral common carotid artery occlusion (UCAO) and received three different treatments: 43.2 mg/200 gBW MLC 901, 21.6 mg/200 gBW MLC 901, and sodium carboxymethyl cellulose (CMC-Na), that were administered orally for 14 days. HSP-70 and MMP-9 protein levels were assessed using enzyme-linked immunosorbent assay (ELISA), and Hsp70 mRNA expression was assessed using quantitative real-time polymerase chain reaction (qRT-PCR). Foot fault scores for evaluation functional outcome and infarction volume were assessed by ImageJ.RESULTS: AIS-induction increased HSP-70, MMP-9, and Hsp70 mRNA expression within 24-48 h. MMP-9, HSP-70 , and Hsp70 mRNA expression were reduced by MLC 901. MLC 901 at dose of 43.2 mg/200 gBW and 21.6 mg/200 gBW were effective in reducing these levels compared to the control. MLC 901 improved functional outcomes and decreased cerebral infarction volume. Moreover, a dosage of 43.2 mg/200 gBW was more effective in reducing Hsp70 mRNA expression and HSP-70, improving functional outcomes, and reducing cerebral infarction volume than a dosage of 21.6 mg/200 gBW, but not MMP-9 protein.CONCLUSION: MLC 901 effectively decreased Hsp70 mRNA expression, HSP-70 and MMP-9 protein levels, infarct volume, and functional outcomes. MLC 901 could be a potential therapeutic agent for AIS.KEYWORDS: MLC 901, HSP-70, MMP-9, acute ischemic stroke

Studi Penggunaan Natrium Valproat Kurang Dari Tiga Bulan Terhadap Magnesium Serum Dan Jumlah Kejang Pasien Epilepsi Di RSUD Dr. Soetomo Latuasan, Ivana Rahayu; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 1 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i1.2049

Epilepsy is a brain disorder characterized by a tendency to cause continuous epilepsy attacks with neurobiological, cognitive, psychological and social consequences. The appearance of temporary signs or symptoms is caused by abnormal and excessive neuron activity in the brain. Sodium valproate can be used as epilepsy therapy because it is effective in inhibiting seizures, partial seizures, and tonic-clonic seizures. The mechanism of action of sodium valproate in the treatment of epilepsy is to increase the inactivation of Na + channels, thereby reducing the nerve's ability to transmit electric charges. Magnesium is a potential modulator of seizure activity because of its ability to inhibit excitation through N-methyl D-aspartate receptors. The aim of this study was to determine serum magnesium levels with sodium valproate treatment and the number of seizures as well as to identify drug-related problems in epilepsy patients who were less than three months old. The research was conducted in the Electroencephalography Room of the Regional Hospital Dr. Soetomo Surabaya by using observational methods in the form of prospective studies using data collection sheets and questionnaires. Samples were taken from July 1 to September 30, 2017. Based on laboratory results, the average magnesium content of patients with seizures was 2.22 mg / dL while non-seizure patients were 2.08 mg / dL. The conclusion of this study is that the use of sodium valproate does not affect magnesium levels in epilepsy patients and epilepsy patients who get sodium valproate therapy have a lower risk of seizures than those who do not get sodium valproate medication.

Studi Penggunaan Obat Phenytoin Kurang dari Tiga Bulan terhadap Kadar Magnesium Serum dan Jumlah Kejang Pasien Epilepsi di RSUD DR. Soetomo Surabaya Sanjiwani, Kadek Siska Febri; Sugianto, Paulus; Kasih, Elisabeth
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2180

Epilepsy is a clinical phenomenon associated with an electrical explosion or excessive abnormal depolarization, which occurs in focus in the brain which causes a paroxysmal awakening. One of the anti-epilepsy drugs is phenytoin which belongs to the hydantoin class. This study aims to describe the serum Mg levels in epilepsy patients with phenytoin drug therapy in Dr. Soetomo General Hospital with a treatment period of less than three months and to identify DRP problems (Drug Related Problems). The method used in this study is prospectively presented by descriptive method (observational). The population in this study were epilepsy patients who were treated at the RSUD dr. Soetomo Surabaya with a sample of 28 epilepsy patients treated at the Outpatient and EEG Neurology Room at Dr. Soetomo General Hospital Surabaya. Results showed that Mg2+ levels in 28 patients with the highest magnesium levels were 2.46 mg / dL. While the lowest magnesium content is 1.78 mg / dL. Conclusions Patients' magnesium levels are still within the normal range but it has not been concluded that phenytoin can increase serum Mg2+ levels and there is no significant difference between phenytoin therapy in epilepsy patients

Studi Penggunaan Kombinasi Obat Fenitoin dan Natrium Valproat terhadap Serum Magnesium dan Jumlah Kejang pada Pasien Epilepsi di RSUD DR. Soetomo Sambono, Vonneth Glorya; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2392

Epilepsy is a clinical condition that is recognized by the pattern of seizures ranging from neurological development status according to age, history of seizures, and prognosis. Clinical research in humans and animals shows that magnesium deficiency can cause seizures. Drug therapy in epilepsy patients can be done by monotherapy and polytherapy. The combination of phenytoin and sodium valproate can be used as a polytherapy. The purpose of this study was to describe the serum magnesium levels and the number of seizures in epilepsy patients who received phenytoin and sodium valproate using a descriptive method prospectively. The parameters used are the conditions of the patient while receiving treatment. Ten epilepsy patients which treated with combination therapy of phenytoin and sodium valproate were used for this research.The results showed that the highest dose used in polytherapy was phenytoin 500 mg and sodium valproate 500 mg 2 x 1 po. The highest normal magnesium level was 2.21 mg / dL (10%). The highest number of seizures was 7 times a month (10%) and no adverse drug interactions occured. Phenytoin and sodium valproate therapy can minimize the number of seizures but do not affect the patient's magnesium level.

VITAMIN B SUPPLEMENTATION IN GERIATRIC PATIENTS: A POTENTIAL STRATEGY TO MANAGING HYPERHOMOCYSTEINEMIA IN CEREBROVASCULAR DISEASE Meryana, Meryana,; Sugianto, Paulus; Erwin, Ferdinand; Jaya, David Karunia
JURNAL WIDYA MEDIKA Vol. 10 No. 2 (2024): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i2.6024

Homocysteine is a non-essential amino acid produced in the biosynthesis pathway between methionine and cysteine. Its levels tend to rise with age due to physiological, lifestyle, and nutritional factors. Elevated homocysteine can induce oxidative stress, inflammation, and endothelial dysfunction, which are critical in the development of cerebrovascular diseases. These mechanisms involve increased free radicals, decreased antioxidant enzyme activity, and enhanced inflammatory responses. Specifically, elevated homocysteine heightens oxidative stress and inflammation by increasing pro-inflammatory cytokines and decreasing anti-inflammatory cytokines, leading to endothelial cell damage and apoptosis. Supplementation with vitamins B6, B9, and B12 has been shown to lower homocysteine levels and reduce the risk of ischemic stroke. However, there is currently no established guideline for the appropriate dosing of these vitamins.

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