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All Journal PharmaCine : Journal of Pharmacy, Medical and Health Science
Simamora, Boy Ignatius
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Uji Toksisitas Subkronik Ekstrak Etanol Daun Sidaguri (Sida Rhombifolia L.) Terhadap Fungsi Hati dan Ginjal Pada Tikus: Subchronic Toxicity of Ethanol Extract of Sidaguri Leaves (Sida Rhombifolia L.) on Liver and Kidney Function in Rats Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Pratama, Reza; Simamora, Boy Ignatius; Oktriyani, Anissa Nadya
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13177

Abstract

Sidaguri leaves (Sida rhombifolia L.) have been widely used in traditional medicine due to their anti-inflammatory, diuretic, and analgesic properties. To ensure their safety, a subchronic toxicity study was conducted using ethanolic extracts of Sida rhombifolia leaves. The study involved male and female Wistar rats administered a dose of 14 mg/kg body weight (BW) daily for 90 days. Toxic symptoms were observed throughout the study period, followed by organ weight assessment, blood biochemical analysis (SGOT, SGPT, creatinine, and urea), and histological examination of heart and kidney tissues. The results showed no toxic symptoms or mortality in the test animals. Levels of SGOT, SGPT, creatinine, and urea remained within normal limits, with no statistically significant differences (p>0.05) between the control and treatment groups. Histological analysis revealed no signs of necrosis in heart and kidney tissues. In conclusion, the ethanolic extract of Sida rhombifolia leaves at a dose of 14 mg/Kg BW is non-toxic and considered safe for daily consumption. Keywords: Sidaguri leaves; Subchronic toxicity;  Histologic;  Liver;  Kidney.
Co-Authors Istiqomah, Aulia Nurfazri Lestari, Kharina Septi Oktriyani, Anissa Nadya Pratama, Reza