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All Journal Jurnal Kefarmasian AKFARINDO ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita Public Health and Safety International Journal (PHASIJ) Jurnal Pengabdian Masyarakat (Jupemas) Jurnal Komunitas Farmasi Nasional PharmaCine: Journal of Pharmacy, Medical and Health Science Indonesian Journal of Herbal Science and Innovation
Kharina Septi Lestari
Universitas Bhakti Kencana
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Edukasi Dan Pemanfaatan Tanaman Obat Untuk Kesehatan Masyarakat Rw 05 Dan Rw 06 Desa Cibiru Hilir, Kecamatan Cileunyi, Kabupaten Bandung Pada Bulan November Tahun 2021 Kharina Septi Lestari; Nur Rakhmanto Heryana; Antri Ariani; Anggi Jamiyanti; Aris Suhardiman; Amelia Kandisa
Jurnal Abdi Masyarakat Kita Vol 2 No 2 (2022): Jurnal Abdi Masyarakat Kita
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/asta.v2i2.245

Abstract

There are many medicinal plants that have the potential to be developed as raw materials for herbal medicines but in fact have not been managed and utilized optimally by the community. There are several problems with conventional medicine, including side effects, high drug resistance, and higher prices, which have created a prolonged economic situation that has hit Indonesia. One solution that can be done in maintaining health conditions is using family medicinal plants. The purpose of family medicinal plants is that they can be used as an alternative to conventional medicine that is easy to find, no money to buy and without the need to come to a health facility. The implementation of education and utilization of family medicinal plants was carried out in RW 05 and RW 06, Cibiru Hilir Village, Cileunyi District, Bandung Regency. The number of participants in this activity involved 60 people (men and women) with an age range of 20 to 50 years, consisting of 30 people from RW 05 and 30 people from RW 06. The methods used in this activity were conducting pre-tests, counseling activities, post test, and delivery of medicinal plant seeds to residents. After the educational activities on the use of medicinal plants took place, public knowledge about family medicinal plants increased as seen from the results of the pre-test and post-test.
AKTIVITAS ANTIHIPERTENSI EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R.Forst. & G.Forst.) PADA MODEL HEWAN HIPERTENSI YANG DIINDUKSI PREDNISON DAN NaCl Kharina Septi Lestari; Elis Susilawati; Aulia Nurfazri Istiqomah; Silvi Nur Amalia; Widhya Aligita
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1103

Abstract

Hypertension is a disease without symptoms that is very dangerous (silent killer) because it is often not realized. Conditions that are not controlled and occur continuously will cause a disease factor related to cardiovascular disease. Empirically, matoa leaves are commonly used as antihypertensive drugs. This study aims to determine the activity of the ethanolic extract of matoa leaves as a diuretic and antihypertensive. Diuretic testing was carried out for 6 hours with urine volume measurement every hour. Each test animal was given warm water as a loading dose, using a comparison (Furosemide 3.6 mg/KgBW) and the matoa leaf ethanol extract test group with doses of 150, 300, and 500 mg/KgBW. Antihypertensive testing was carried out in a preventive manner using Prednisone 1.5 mg/KgBW and NaCl 2%, comparison (Hydrochlorothiazide 2.25 mg/KgBW) and the test group ethanol extract of matoa leaves with doses of 150, 300, and 500 mg/KgBW. given orally for 14 days. The test parameters were urine volume, systolic blood pressure and diastolic pressure. The data obtained were analyzed using One Way ANOVA and Kruskall Wallis. The results showed that the ethanol extract of matoa leaves could increase urine output, and decrease systolic and diastolic blood pressure because it had a comparable activity with the comparison group (p<0.05). A dose of 150 mg/kgBW has the most effective activity as an antihypertensive.
PELATIHAN PEMANFAATAN BAHAN HERBAL SEBAGAI JAMU IMUNOSTIMULAN BAGI KELOMPOK PKK RW 001 DESA MAJASETRA KECAMATAN MAJALAYA KABUPATEN BANDUNG Aulia nurfazri istiqomah; Asep Roni; Kharina Septi Lestari; Fikri Mourly Wahyudi; Agus Miraj Darajat; Novitasari tsamrotul fuadah
Jurnal Pengabdian Masyarakat (Jupemas) Vol 2, No 2 (2021)
Publisher : Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jupemas.v2i2.859

Abstract

Sampai saat ini, dapat dikatakan kita masih berada dalam kondisi pandemic COVID-19, khususnya di Indonesia. Telah kita ketahui bersama bahwa dalam menghadapi pandemic COVID-19 ini kita harus menjaga sistem kekebalan tubuh untuk meminimalisir kemungkinan terpaparnya tubuh oleh virus COVID-19 dan patogen lainnya. Program pengabdian kepada masyarakat ini dilaksanakan di Kp. Pangkalan RW. 001 Desa Majasetra, Kecamatan Majalaya, Kabupaten Bandung berupa pelatihan pemanfaatan bahan herbal sebagai jamu imunostimulan atau peningkat daya tahan tubuh kepada kelompok PKK setempat yang nantinya akan disebarluaskan kepada masyarakat. Dari hasil pelaksanaan kegiatan pengabdian kepada masyarakat ini, warga RW 001 Kp. Pangkalan, Desa Majasetra, Kecamatan Majalaya, Kabupaten Bandung telah menerima pemahaman akan pentingnya menjaga daya tahan tubuh terlebih dalam situasi pandemi dengan memanfaatkan bahan-bahan yang ada di sekitar kita.
Proteksi Ekstrak Rimpang Pacing Terhadap Resistensi Insulin pada Model Hewan yang Diinduksi Pakan Tinggi Lemak Dan Fruktosa Aulia Nurfazri Istiqomah, Aulia Nurfazri Istiqomah; Kharina Septi Lestari; Imas Fauzya Zahra
Jurnal Komunitas Farmasi Nasional Vol. 4 No. 1 (2024): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Insulin resistance is a condition where the sensitivity of cells or tissues to insulin decreases, which is one of the main factors causing type 2 diabetes mellitus. Current diabetes therapy is still limited to synthetic drugs which can cause side effects, so alternative diabetes therapy is being sought. using natural materials, one of which is using pacing. The pacing rhizome plant contains the compound diosgenin which has antidiabetic properties. This study aims to determine the activity of ethanol extract of pacing rhizomes in increasing insulin sensitivity and the effective dose in increasing insulin sensitivity. Testing was carried out preventively using an animal model of insulin resistance induced by high fat and fructose feed orally for 42 days. The test animals were divided into six groups, namely normal, induction, comparison metformin 45 mg/KgBW, ethanol extract of rhizome pacing (EERP) dose 150 mg/KgBW, 300 mg/KgBW and 450 mg/KgBW. The parameters measured were blood glucose levels and insulin tolerance test constants. From the research results, it was found that ethanol extract of pacing rhizome at a dose of 300 mg/KgBW could increase insulin sensitivity. Keywords: insulin resistance, pacing, blood glucose levels, Costus speciosus
Recent Updates on the Potential of Medicinal Plants from Indonesia as Anti-Atherosclerotic Agents Prasesti, Gayuk Kalih; Narsa, Angga Cipta; Rijai, Akhmad Jaizzur; Lestari, Kharina Septi; Zulkaida, Zulkaida
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52261

Abstract

Atherosclerosis is one of the causes of problems in the cardiovascular system. This condition can be prevented by using natural products, one of which is medicinal plants. This review collects data on medicinal plants that are easily found in Indonesia that can reduce or improve atherosclerosis conditions. There are 10 plants reviewed that have a high level of safety and potential to be developed as medicine. The plant parts used are fruit and leaves. Some are commonly used as cooking spices such as turmeric and garlic which are found to be useful for improving atherosclerosis conditions. In the context of modern drug development, Indonesia holds significant potential for exploring these plants as sources of active compounds for pharmaceutical applications. Scientific studies of these natural materials are crucial for identifying bioactive components and understanding their mechanisms of action. With the right approach, Indonesia's natural resources could form the basis for developing new, safer, and more effective drugs. Additionally, Indonesia has a considerable opportunity in the global market for natural health products, including nutraceuticals and dietary supplements, as global interest in natural health solutions continues to grow.
Evaluasi SIMPUS Menggunakan Metode (HOT-Fit Model) Di Puskesmas Wilayah Kecamatan Cibiru Rizky Prabawa Nugraha; Budiman; Dyan Kunthi Nugrahaeni; Suhat; Novie Elvinawaty Mauliku; Kharina Septi Lestari
Public Health and Safety International Journal Vol. 5 No. 02 (2025): Public Health and Safety International Journal (PHASIJ)
Publisher : YCMM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55642/phasij.v5i02.1172

Abstract

Teknologi informasi dan komunikasi terus berkembang dengan pesat mendorong pemerintah di daerah melakukan pengelolaan dan pengembangan sistem informasi kesehatan sesuai yang dibutuhkan. Sistem Informasi Manajemen Puskesmas (SIMPUS) adalah suatu tatanan yang menyediakan informasi untuk membantu proses pengambilan keputusan dalam melaksanakan menajemen puskesmas dalam mencapai sasaran kegiatannya. SIMPUS mempunyai fungsi mengelola data pasien mulai dari pendaftaran, registrasi, pemeriksaan, serta pemberian obat pasien. Data yang diinput ditampung dalam sebuah database pasien yang nantinya akan dikelompokkan sesuai dengan parameter untuk kebutuhan pelaporan sehingga dibutuhkannya pengelolaan manajemen SIMPUS yang baik. Desain penelitian yang digunakan pada penelitian ini menggunakan rancangan penelitian cross sectional yaitu rancangan penelitian yang menganalisis hubungan antara faktor-faktor sebab dan akibat dengan berbagai pendekatan. Jumlah sampel pada penelitian ini sebanyak 52 orang. Teknik sampling yang digunakan dalam penelitian ini adalah dengan teknik Non Probability Sampling. Berdasarkan hasil analisis diketahui nilai signifikansi untuk pengaruh variabel Human, Organization, dan Technology secara simultan terhadap variabel Net Benefit adalah sebesar 0,018 < 0,05 dan nilai f hitung sebesar 3,697 > f tabel 2,794, sehingga dapat disimpulkan bahwa Ha diterima yang berarti terdapat pengaruh variabel Human, Organization, dan Technology secara simultan terhadap variabel Net Benefit.
Inovasi Pengolahan Tanaman TOGA Jahe menjadi Minuman Granul Fungsional Bernilai Kesehatan dan Ekonomi Lestari, Kharina Septi; Asnawi, Aiyi; Purwaniati, Purwaniati; Pahlevi, Muhamad Reza; Aligita, Widhya; Kosasih, Kosasih
Jurnal Abdimas Kartika Wijayakusuma Vol 7 No 1 (2026): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v7i1.1240

Abstract

RW 09 Cipadung Kidul Panyileukan dalam kegiatan pengabdian kepada masyarakat ini merupakan kelompok warga yang telah memiliki Taman Tanaman Obat Keluarga (TOGA), namun pemanfaatannya masih terbatas untuk kebutuhan konsumsi rumah tangga. Jahe sebagai komoditas utama TOGA belum dikembangkan menjadi produk bernilai tambah karena keterbatasan pengetahuan, keterampilan teknis, serta pemahaman mengenai aspek higienitas, pengemasan, dan potensi ekonomi produk herbal. Program ini bertujuan untuk mengoptimalkan pemanfaatan TOGA melalui pengolahan jahe menjadi minuman granul fungsional yang praktis dan memiliki nilai jual. Metode pelaksanaan mencakup edukasi mengenai manfaat jahe dan keamanan pangan, pelatihan teknis pembuatan minuman granul jahe secara higienis, serta pendampingan dalam proses pengemasan dan penyimpanan produk. Evaluasi kegiatan dilakukan melalui pre-test, post-test, dan observasi langsung terhadap peserta. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan dan keterampilan masyarakat dalam memproduksi minuman granul jahe, tersedianya produk contoh siap saji, serta tersusunnya modul panduan pembuatan produk. Selain itu, kegiatan ini juga dipublikasikan melalui berbagai media dan difasilitasi pendaftaran Hak Kekayaan Intelektual (HKI) sebagai bentuk perlindungan terhadap inovasi yang dihasilkan. Melalui program ini, diharapkan kesehatan masyarakat dapat meningkat sekaligus membuka peluang usaha berbasis potensi lokal secara berkelanjutan.
UJI AKTIVITAS INHIBISI TIROSINASE EKSTRAK ETANOL RIMPANG PACING (Costus speciosus) Lestari, Kharina Septi; Wahyudi, Vierly Stephany Putri; Kaniawati, Marita; Istiqomah, Aulia Nurfazri; Pratama, Reza
Jurnal Kefarmasian Akfarindo Vol 11 No 1 (2026)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1235

Abstract

Melanin merupakan pigmen utama yang menentukan warna kulit, namun produksinya yang berlebihan dapat menyebabkan hiperpigmentasi seperti melasma. Enzim tirosinase memiliki peran penting dalam biosintesis melanin, sehingga penghambatan aktivitas enzim ini menjadi target utama dalam penanganan hiperpigmentasi. Rimpang pacing (Costus speciosus) diketahui mengandung berbagai senyawa metabolit sekunder seperti flavonoid, fenolik, tanin, dan saponin yang dilaporkan memiliki aktivitas antioksidan serta berpotensi menghambat aktivitas tirosinase. Penelitian ini bertujuan untuk mengetahui aktivitas inhibitor tirosinase dari ekstrak etanol rimpang pacing (Costus speciosus), menentukan nilai persen inhibisi, serta nilai IC₅₀-nya. Penelitian ini merupakan penelitian eksperimental laboratorium yang dilakukan secara in vitro. Ekstraksi dilakukan menggunakan metode maserasi dengan pelarut etanol 96%. Penapisan fitokimia menunjukkan adanya kandungan flavonoid, alkaloid, tanin, saponin, steroid, dan senyawa fenolik. Uji aktivitas tirosinase dilakukan secara in vitro menggunakan metode ELISA dengan substrat L-DOPA dan enzim mushroom tyrosinase, serta pengukuran absorbansi pada panjang gelombang 490 nm. Data persen inhibisi dihitung dari nilai absorbansi hasil pengujian, kemudian digunakan untuk menentukan nilai IC₅₀ melalui analisis hubungan antara konsentrasi sampel dan persen inhibisi. Hasil penelitian menunjukkan bahwa ekstrak etanol rimpang pacing memiliki aktivitas penghambatan enzim tirosinase dengan persentase inhibisi tertinggi sebesar 65,91% pada konsentrasi 10.000 ppm. Aktivitas penghambatan ekstrak tergolong lebih lemah dibandingkan kontrol positif asam kojat yang memiliki nilai IC₅₀ sebesar 45,96 ppm. Dengan demikian, ekstrak rimpang pacing memiliki potensi sebagai agen anti-hiperpigmentasi alami, namun masih memerlukan pengembangan lebih lanjut untuk meningkatkan efektivitasnya.
Uji Toksisitas Subkronik Ekstrak Etanol Daun Sidaguri (Sida Rhombifolia L.) Terhadap Fungsi Hati dan Ginjal Pada Tikus: Subchronic Toxicity of Ethanol Extract of Sidaguri Leaves (Sida Rhombifolia L.) on Liver and Kidney Function in Rats Kharina Septi Lestari; Aulia Nurfazri Istiqomah; Reza Pratama; Boy Ignatius Simamora; Anissa Nadya Oktriyani
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13177

Abstract

Sidaguri leaves (Sida rhombifolia L.) have been widely used in traditional medicine due to their anti-inflammatory, diuretic, and analgesic properties. To ensure their safety, a subchronic toxicity study was conducted using ethanolic extracts of Sida rhombifolia leaves. The study involved male and female Wistar rats administered a dose of 14 mg/kg body weight (BW) daily for 90 days. Toxic symptoms were observed throughout the study period, followed by organ weight assessment, blood biochemical analysis (SGOT, SGPT, creatinine, and urea), and histological examination of heart and kidney tissues. The results showed no toxic symptoms or mortality in the test animals. Levels of SGOT, SGPT, creatinine, and urea remained within normal limits, with no statistically significant differences (p>0.05) between the control and treatment groups. Histological analysis revealed no signs of necrosis in heart and kidney tissues. In conclusion, the ethanolic extract of Sida rhombifolia leaves at a dose of 14 mg/Kg BW is non-toxic and considered safe for daily consumption. Keywords: Sidaguri leaves; Subchronic toxicity;  Histologic;  Liver;  Kidney.
Pengaruh Toksisitas Subkronik Ekstrak Etanol Rimpang Pacing (Costus speciosus) terhadap Fungsi Hati pada Tikus Aulia Nurfazri Istiqomah; Siti Kholisatun Nisa; Kharina Septi Lestari
Indonesian Journal of Herbal Science and Innovation Vol. 1 No. 1 (2025): Indonesian Journal of Herbal Science and Innovation
Publisher : PT CENDEKIA SCIENCE AND TECHNOLOGY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64673/ijherbsi.v1i1.1

Abstract

Traditional medicine has been an integral part of healing practices for thousands of years. With its rich biodiversity, Indonesia boasts approximately 30,000 plant species with potential medicinal properties, one of which is the rhizome of Costus speciosus (pacing). This plant is known for its various benefits, including antifungal, antioxidant, anthelmintic properties, and traditional contraceptive use. The aim of this study was to investigate the subchronic toxicity of ethanol extract from pacing rhizomes on liver function in male and female rats. The experiment was conducted using Wistar rats, with two groups (10 males and 10 females per group), which were treated with a 300 mg/kg body weight dose of the extract for 90 days. Liver histology, organ index, and levels of the enzymes SGOT and SGPT were observed. The results indicated that the ethanol extract of pacing rhizomes, at this dose, did not cause significant changes in body weight, liver organ index, or SGOT/SGPT levels in both male and female rats. In conclusion, the study suggests that the ethanol extract of pacing rhizomes at 300 mg/kg body weight for 90 days does not show signs of liver toxicity in rats. These findings support the potential use of pacing rhizomes as a safe ingredient in traditional medicine. However, further studies are needed to assess possible toxic effects and animal mortality over longer durations.
Co-Authors Agus Miraj Darajat Agus Sulaeman Ai Siti Farihah Aiyi Asnawi Aligita, Widhya Amelia Kandisa Angga Cipta Narsa Anissa Nadya Oktriyani Antri Ariani Aris Suhardiman Aulia Utami Widiati Boy Ignatius Simamora Budiman Dika Azhar Ramadhan Dyan Kunthi Nugrahaeni Elis Susilawati Endah Astri Wijiastuti Fikri Mourly Wahyudi Imas Fauzya Zahra Istiqomah, Aulia Nurfazri Jamiyanti, Anggi KOSASIH KOSASIH, KOSASIH Marita Kaniawati Marita Kaniawati Novie Elvinawaty Mauliku Novitasari Tsamrotul Fuadah Nur Rakhmanto Heryana Oktriyani, Anissa Nadya Pahlevi, Muhamad Reza Prasesti, Gayuk Kalih Pratama, Reza Purwaniati, Purwaniati - Reza Pratama Rijai, Akhmad Jaizzur Rizky Prabawa Nugraha Roni, Asep Silvi Nur Amalia Simamora, Boy Ignatius Siti Kholisatun Nisa Suhat Suhat Wahyudi, Vierly Stephany Putri Widhya Aligita Yanni Dhiani Mardhiani Zulkaida, Zulkaida