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Wiryanto , Wiryanto
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Analisis Masalah Terkait Obat pada Resep Pasien Diabetes Mellitus Tipe 2 di Rumah Sakit “X” Provinsi Aceh : Studi Cross-sectional Retrospektif Zahniar, Zahniar; Khairunnisa, Khairunnisa; Wiryanto , Wiryanto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1087

Abstract

Background: The complexity of treatment regimens and the simultaneous use of multiple medications increase the risk of drug-related problems (DRPs), which can affect the effectiveness, safety, and security of patient treatment. Objective: This study aims to explore and identify Drug-Related Problems in the treatment of patients with type 2 diabetes mellitus (T2DM) at Hospital “X”, Aceh Province, Pidie District, Aceh. Methods: This study is a quantitative descriptive study with a retrospective cross-sectional design of prescriptions for T2DM patients during the period of January-December 2024 at Hospital “X”, Aceh Province. Results: Analysis of 395 T2DM patient prescriptions that met the inclusion criteria identified a total of 1,275 Drug-Related Problems (DRPs) incidents. Potential MTO in category P.2 (drug safety) were the most common, accounting for 1,080 cases. The majority of these cases were attributed to inappropriate drug selection, followed by 132 incidents related to drug preparation. The high incidence of MTO was primarily due to adverse drug reactions and drug interactions, which were closely associated with inappropriate drug choices or improper drug combinations. The importance of a pharmaceutical service approach in improving patient safety and therapeutic effectiveness in the management of DMT2, especially in the prevention and management of drug-related problems (MTO). Conclusion: The most dominant DRP category identified was drug safety (P.2), primarily caused by inappropriate drug selection. Drug interactions resulting from suboptimal therapeutic combinations were the main contributing factor to MTO, with the majority classified as moderate in severity. These findings highlight the need for more active and systematic clinical pharmacy interventions in reviewing medication regimens, along with interprofessional collaboration to enhance therapeutic effectiveness, ensure patient safety, and reduce the incidence of MTO in the management of type 2 diabetes mellitus (T2DM).  
Kajian Sistem Pelaporan Farmakovigilans Berdasarkan Pelaporan Rumah Sakit Di Sumatera Utara Pada Rentang 2019-2024 Nasution, Mai Syaroh; Wiryanto , Wiryanto; Wangge , Grace
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1212

Abstract

Pharmacovigilance safeguards patient safety, yet hospital ADR reporting in North Sumatra remains limited. This research to assess compliance with BPOM’s 10 completeness criteria and identify determinants that support or hinder implementation. Methods: A mixed methods approach with a sequential explanatory design was applied. descriptive analysis of 2019-2024 e-MESO reports and in-depth interviews with hospitals categorized as Complete, Incomplete, and Non-reporting. Results: Out of 210 hospitals, only 11 (5%) actively reported through e-MESO, producing 50 reports, 98% complete and 2% incomplete. About 74% were spontaneous reports, mostly skin reactions, with 40% serious cases in elderly patients. Qualitative analysis revealed seven main themes: understanding, reporting process, barriers, management support, e-MESO system, expectations, and interprofessional collaboration. Conclusion: While individual report completeness is high, system-level participation is low, so full compliance with the 10 criteria is not yet achieved. Reporting quality is largely shaped by managerial support, organizational readiness, and interprofessional collaboration. Recommended actions include expanding SOP-based reporting on the 10 criteria, appointing a clinical pharmacist as the person-in-charge, conducting cross-profession training, and coordinating e-MESO technical issues with BPOM particularly strengthening type-C hospitals.
Co-Authors Khairunnisa Khairunnisa Nasution, Mai Syaroh Wangge , Grace Zahniar, Zahniar