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All Journal Medical Laboratory Technology Journal Journal of Pharmaceutical and Sciences. Life Science and Biotechnology
Zahniar, Zahniar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Differential Leukocyte Count Responses Post Injection of Duffy-binding-like Domain-2β of PfEMP1 Recombinant Protein in Wistar Rat Zahniar, Zahniar; Sulistyaningsih, Erma; Rachmania, Sheilla; Dewi, Rosita; Kusuma, Irawan Fajar
Medical Laboratory Technology Journal Vol. 11 No. 1 (2025): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i1.628

Abstract

Malaria due to Plasmodium falciparum causes a high mortality rate, and vaccination is a valuable approach to control it. One malaria vaccine candidate is Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1), specifically Duffy binding-like 2β (DBL2β) domain (DBL2β-PfEMP1), which has a vital role in severe malaria pathogenesis. The DBL2β-PfEMP1 recombinant protein is immunogenic. This study aimed to investigate the immune response of DBL2β-PfEMP1 protein by analyzing the differential leukocyte count. Twenty-three rats were randomly divided into control and five treatment groups. Rats were injected on days 0, 21, and 42 with a physiological solution of 0.9% NaCl, adjuvant, DBL2β-PfEMP1 protein, and each mixture of DBL2β-PfEMP1 protein with doses of 150, 300, and 450 µg/200gBW and adjuvant. Blood was collected on day 56 and prepared for differential leukocyte count examination with a visual microscopic examination by two expert observers. The results showed that DBL2β-PfEMP1 recombinant protein and adjuvant increased the eosinophils and neutrophils but decreased monocytes and lymphocytes and did not affect the basophils. Statistical analysis showed significant differences between groups for eosinophils (between control and DBL groups; Adj and DBL groups; DBL and other groups except DBL150+adj) and monocytes (between control and all doşe groups with adjuvant; DBL and all doşe groups with aduvant), but not for basophils, neutrophils, and lymphocytes. In conclusion, the serial injection of DBL2β-PfEMP1 recombinant protein showed different responses in each leukocyte cell type. Further analysis by time-series differential leukocyte count examination will be essential to determine the responses of each type of leukocyte to support the research on malaria vaccine development.
Characterization of Apyrase from the Salivary Glands of Ae. aegypti Based on Bioinformatics Database Wathon, Syubbanul -; Laili, Alvina Nur; Iflaha, Adriana; Widyadana, Kaysha Rahmadita; Zahniar, Zahniar; Saraswati, Dyah Rahmadhani; Oktarianti, Rike; Senjarini, Kartika
Life Science and Biotechnology Vol. 2 No. 1 (2024): May 2024
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/lsb.v2i1.48353

Abstract

The salivary glands of mosquitoes, which act as disease vectors, contain biological components that facilitate the blood-feeding process and transmit pathogens to the human body. Apyrase, a protein from the salivary glands of Ae. aegypti, is known to be an immunogenic protein that influences the host's immunity. It can prevent platelet aggregation by hydrolyzing ATP or ADP into AMP and thus facilitate the blood-feeding process. This mechanism is also exploited by pathogens to obtain entry into the host's body. Vaccination with the apyrase protein could control dengue virus transmission by enhancing the immune response to inhibit the pathogen's entry. To examine the potential of apyrase, it is critical to explore its nature and characteristics by using bioinformatics databases. This quantitative descriptive study involved apyrase protein from the salivary glands of Ae. aegypti obtained from several bioinformatics databases, namely UniProt, SWISSMODEL, ENZYME, Rhea, CFSSP, GlyCosmos, STRING, and QuickGo. The findings contribute to a more fine-cut understanding of apyrase as a potential vaccine to inhibit dengue transmission.
Analisis Masalah Terkait Obat pada Resep Pasien Diabetes Mellitus Tipe 2 di Rumah Sakit “X” Provinsi Aceh : Studi Cross-sectional Retrospektif Zahniar, Zahniar; Khairunnisa, Khairunnisa; Wiryanto , Wiryanto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1087

Abstract

Background: The complexity of treatment regimens and the simultaneous use of multiple medications increase the risk of drug-related problems (DRPs), which can affect the effectiveness, safety, and security of patient treatment. Objective: This study aims to explore and identify Drug-Related Problems in the treatment of patients with type 2 diabetes mellitus (T2DM) at Hospital “X”, Aceh Province, Pidie District, Aceh. Methods: This study is a quantitative descriptive study with a retrospective cross-sectional design of prescriptions for T2DM patients during the period of January-December 2024 at Hospital “X”, Aceh Province. Results: Analysis of 395 T2DM patient prescriptions that met the inclusion criteria identified a total of 1,275 Drug-Related Problems (DRPs) incidents. Potential MTO in category P.2 (drug safety) were the most common, accounting for 1,080 cases. The majority of these cases were attributed to inappropriate drug selection, followed by 132 incidents related to drug preparation. The high incidence of MTO was primarily due to adverse drug reactions and drug interactions, which were closely associated with inappropriate drug choices or improper drug combinations. The importance of a pharmaceutical service approach in improving patient safety and therapeutic effectiveness in the management of DMT2, especially in the prevention and management of drug-related problems (MTO). Conclusion: The most dominant DRP category identified was drug safety (P.2), primarily caused by inappropriate drug selection. Drug interactions resulting from suboptimal therapeutic combinations were the main contributing factor to MTO, with the majority classified as moderate in severity. These findings highlight the need for more active and systematic clinical pharmacy interventions in reviewing medication regimens, along with interprofessional collaboration to enhance therapeutic effectiveness, ensure patient safety, and reduce the incidence of MTO in the management of type 2 diabetes mellitus (T2DM).  
Co-Authors Erma Sulistyaningsih Iflaha, Adriana Irawan Fajar Kusuma Kartika Senjarini Khairunnisa Khairunnisa Laili, Alvina Nur Rike Oktarianti Rosita Dewi Saraswati, Dyah Rahmadhani Sheilla Rachmania, Sheilla Wathon, Syubbanul - Widyadana, Kaysha Rahmadita Wiryanto , Wiryanto