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All Journal Indonesian Journal of Chemistry Pharmaceutical Sciences and Research (PSR)
Aswan, Pedro Anugerah
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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Advancing Herbal Medicine: The Role of Nanosomal Technology in Treating Skin Diseases Aswan, Pedro Anugerah; Maggadani, Baitha Palanggatan; Fachri, Wilzar; Iswandana, Raditya
Pharmaceutical Sciences and Research Vol. 12, No. 2
Publisher : UI Scholars Hub

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Abstract

Herbal medicine has become popular worldwide, especially in developing countries, with around 80% of the population opting for herbal treatments. The perceived benefits of natural remedies, such as affordability and fewer side effects, drive this trend. Herbal therapies effectively manage skin diseases, infections, and common ailments. However, the absorption of bioactive compounds in herbal extracts is often limited. Recent developments in nano-based herbal delivery systems, like nanosomal, show promise in enhancing the efficacy of herbal remedies for topical applications, providing improved solubility, stability, and skin penetration. This review describes various nanosomal studies developed and successfully used to enhance the topical delivery of natural compounds, including liposomes, ethosomes, transfersomes, transethosomes, phytosomes, and niosomes.
Simultaneous HPLC Analysis of Asiaticoside and α-Mangostin in Nanoethosomal Carriers Aswan, Pedro Anugerah; Maggadani, Baitha Palanggatan; Fachri, Wilzar; Iswandana, Raditya
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111150

Abstract

The development of robust analytical methods is essential for quality control of nanoethosomal formulations containing asiaticoside and α-mangostin, bioactive compounds with anti-inflammatory and antioxidant properties. Simultaneous quantification within nanocarriers is challenging and requires validated techniques. This study established a precise HPLC method, in accordance with ICH Q2(R2) guidelines, for the concurrent determination of both compounds. The technique demonstrated excellent linearity (R2 > 0.999), precision (%RSD < 2%), and accuracy (95–105% recovery). The nanoethosomal system also achieved high encapsulation efficiencies of 94.76% for asiaticoside and 99.27% for α-mangostin. This validated method provides a reliable tool for standardizing these complex nano-formulations, supporting their further development and clinical translation.
Co-Authors Baitha Palanggatan Maggadani, Baitha Palanggatan Fachri, Wilzar Raditya Iswandana