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Baitha Palanggatan Maggadani, Baitha Palanggatan
Faculty of Pharmacy, Universitas Indonesia

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Pengembangan Metode Analisis Agen Pengatur Keasaman Pakan Ternak Menggunakan Metode Kromatografi Cair Kinerja Tinggi Asih, Ninis Kurnia; Harmita, Harmita; Maggadani, Baitha Palanggatan
Pharmaceutical Sciences and Research Vol. 4, No. 3
Publisher : UI Scholars Hub

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Quantitative analysis of organic acid in acidifier product is needed to maintain product effectiveness in repressing microbial growth and lowering feed and gastrointestinal tract pH. The aim of this research is determining the level of formic and lactic acid in two acidifiers from the market. Analysis were performed using reversed phase High Performance Liquid Chromatography (HPLC) with LiChrospher® 100 RP-18 column (250 x 4.0 mm, 5μm, Merck), buffer potassium dihydrogenphosphate 50 mM-TEA 0,5% pH 4,00 as mobile phase and flow rate 0,6 mL/min. Wavelength used in the analysis was 214 nm. Validation methods provide results of recovery by 98.02%-101.97% for formic acid and 97.09%-102.78% for lactic acid, RSD <0.59% for formic acid and 1.28% for lactic acid, LOD 63.05 µg/mL for formic acid 4.55 µg/mL for lactic acid, LOQ 210.16 µg/mL for formic acid and LOD 15.18 µg/mL for lactic acid. The analysis method gives linearity in the range of 439.2 -1764.61 µg/mL for formic acid with correlation coefficient (r) 0.9992 while lactic acid linearity range was 47.88 µg/mL-193.44 g/mL with a correlation coefficient (r) 0.9994. Conformity product A to its label provides the results of 108.19%-109.82% formic acid and 156.88%-167.90% lactic acid whereas the result for product B were 101.65%-109.95% formic acid and 151.10%-172.82% lactic acid.
Skrining dan evaluasi aktivitas kitinase dari sembilan isolat bakteri lokal Maggadani, Baitha Palanggatan; Setyahadi S, Siswa; Harmita, Harmita
Pharmaceutical Sciences and Research Vol. 4, No. 1
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Chitinase is an enzyme that degrades chitin on β-1,4-acetamido-2-deoxy-D-glycoside bound to produce Chitin oligosaccharide or its soluble monomer, N-acetylglucosamine (NAG). Chitinase are usually produced naturally by chitinolytic microorganism that are found in soil or water environment. Chitinase have been widely used for biocontrol agents of plant pests. The product from chitinase hydrolysis can be used as antiinflammatory agent and anti hyperpigmentation. This research was aimed to screen and evaluate the chitinolytic ability of 9 isolate. The best isolate was the one which produced high chitinolytic activity and hydrolyzed chitin into NAG. 9 isolate were examined and BPPTCC-2 was the best isolate which produced highest level of chitinolytic activity 0.1780 U/ml. The chitinase was able to hydrolyzed chitin resulting high yields of NAG 11.5% as the only product.
Evaluasi Aktivitas Antioksidan Senyawa 4-[(E)-2-(4-okso-3-fenilkuinazolin-2-il)etenil]-benzensulfonamida dan Analognya Jatmika, Catur; Maggadani, Baitha Palanggatan; Hayun, Hayun
Pharmaceutical Sciences and Research Vol. 2, No. 3
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Quinazolinone derivative compounds exhibit a broad spectrum of biological activity, including antioxidant. Quinazolinone derivative compound 4-[(E)-2-(4-oxo-3-phenyl quinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs (2a-f) have been synthesized and demonstrated its activity as a selective inhibitor of cyclooxygenase-2. The aim of this research was to evaluate the antioxidant activity of compound 4-[(E) -2-(4-oxo-3-fenilkuinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs with DPPH radical scavenging method, ferric reducing activity potential (FRAP), and phosphomolybdenum method. The experiment revealed that the % inhibition and antioxidant capacity of compound 2c, 2e and 2f were higher compared to compound 2a, 2b and 2d. The DPPH radical scavenging analysis found that the % inhibition of compound 2c, 2e and 2f at high concentration of compound solution (1000 µg/mL) were 4.8 %, 3.46 %, and 3.68 %, respectively. While the total antioxidant capacity of compound 2c, 2e and 2f were recorded 37.93, 33.4, and 46.3 µg ascorbic acid equivalence/mg of compound, respectively. However the antioxidant activity of all synthesized compounds (2a-f) were lower than the standard ascorbic acid.
Challenges and Future Perspective of Gastroretentive Mucoadhesive Dosage Forms Akbar, Rayhan; Setiawan, Heri; Maggadani, Baitha Palanggatan; Iswandana, Raditya; Setio Putri, Kurnia Sari
Pharmaceutical Sciences and Research Vol. 11, No. 2
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Gastroretentive Mucoadhesive Dosage Form (GMDF) is one type of Gastroretentive Drug Delivery System (GRDDS) technology designed to exploit the adhesiveness of dosage forms in the gastric mucosa. This aims to increase drug residence time, enhance drug solubility and absorption, and ultimately improve drug bioavailability and therapeutic effect. Various studies have explored the use of different polymers to develop GMDF systems and dosage forms. However, despite extensive research in this field, there are still limited GMDF products approved by the US FDA and INA FDA. Therefore, this review addresses the challenges in developing GMDF, its current state, and potential future opportunities. This literature review is performed by searching Google Scholar, PubMed, and ScienceDirect and Google Patents using the terms “gastroretentive”, “mucoadhesive”, “challenge”, “strategy”, and “patent.” Additionally, searches were conducted in the US FDA and INA FDA Drug Approval Databases. Based on our study, we identified numerous challenges in developing GMDF, including patient physiological challenges, drug formulas, production processes, product analysis, and clinical trials. To address these challenges, multiple strategies should be developed to optimize the formulation, production process, and product analysis of GMDF, ultimately leading to successful clinical trials and regulatory approval of this product.
Recent Updates on Dried Blood Spot and Volumetric Absorptive Microsampling as Microsampling Technique for Antiepileptic Drug Determination: A Systematic Review Pridilla, Asmiladita; Harahap, Yahdiana; Purwanto, Denni Joko; Maggadani, Baitha Palanggatan
Pharmaceutical Sciences and Research
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Implementation of Therapeutic Drug Monitoring (TDM) can be useful for patients with uncontrolled seizures. This review article aims to collect and compare the recent development of bioanalytical methods for antiepileptic drugs using microsampling techniques, namely DBS (Dried Blood Spot) and VAMS (Volumetric Absorptive Microsampling). Studies were searched through databases, namely Science Direct, Pubmed, and the Google Scholar search engine using pre-determined keywords. Studies published between 2019 and 2024 and used micro-sampling techniques for antiepileptic drug analysis were included. Non-English studies, non-related studies, duplication, and full text unavailable were excluded. Primary sources were used to build a conclusion regarding the purpose of this review article. A total of 342 articles were identified from databases. From 8 primary studies included, analytical methods for 21 drug compounds as antiepileptic agents and 4 of their metabolites in DBS and VAMS were found. A summary of sample preparation, analytical method, and validation were presented in the narrative form of this review. Concentrations measured using DBS and VAMS demonstrate a strong correlation with conventional matrices; however, conversion factors based on the blood-to-plasma ratio are necessary for accurate comparison. Additionally, the comparison results between DBS and VAMS technique for TDM is still unsatisfactory to prove their interchangeability. Therefore, this comparison needs further evaluation with more samples and more analytes. Analysis of antiepileptic drugs using VAMS is also still limited and further optimization can be carried out to produce more stable, sensitive, fast, and suitable for TDM practice.
Co-Authors AA Sudharmawan, AA Akbar, Rayhan Asih, Ninis Kurnia Catur Jatmika, Catur DENNI JOKO PURWANTO, DENNI JOKO Harmita Harmita, Harmita Hayun Hayun, Hayun Kurnia Sari Setio Putri, Kurnia Sari Setio Pridilla, Asmiladita Raditya Iswandana Setyahadi S, Siswa Yahdiana Harahap