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All Journal Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Riset Daerah
Erna Yovi Kurniawati
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Agriculture, Biological Sciences & Forestry Dentistry Economics, Econometrics & Finance Health Professions Nursing Public Health Social Sciences Veterinary Other

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ROLE OF AMH, FSH, ANDROGEN AND ESTRADIOL AS MARKER OF PCOS FOLLICULOGENESIS: NARATIVE REVIEW Erna Yovi Kurniawati; Noor Pramono
An-Najat Vol. 3 No. 4 (2025): November: An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i4.3451

Abstract

Polycystic Ovary Syndrome (PCOS) poses a significant challenge in reproductive medicine due to its complex aetiology involving hormonal dysregulation, metabolic perturbations, and genetic predispositions. Central to PCOS pathogenesis is the disruption of folliculogenesis, the process vital for female reproductive health, characterized by the formation of numerous small antral follicles that fail to mature properly. This narrative review explores the roles of Anti-Müllerian Hormone (AMH), Follicle-Stimulating Hormone (FSH), androgens, and oestradiol as markers of PCOS folliculogenesis. AMH, prominently produced by granulosa cells, exhibits elevated levels in PCOS, contributing to excessive follicular recruitment and persistence. Dysregulation of FSH, androgen, and oestradiol further complicates follicular development, exacerbating PCOS-related abnormalities. Understanding the interplay between these markers is crucial for diagnosing and managing PCOS. However, challenges persist, including the lack of standardized serum AMH thresholds and technical limitations in testing methodologies. Further research is warranted to establish these thresholds and refine diagnostic approaches. Moreover, insights into hormonal mechanisms in PCOS folliculogenesis hold promise for developing targeted therapies to alleviate its impact on reproductive health.
Intervensi Edukasi Gaya Hidup dalam Meningkatkan Pengetahuan tentang Faktor Risiko Infertilitas pada Wanita Usia Reproduktif Elfrida Iriyani`; Erna Yovi Kurniawati
Jurnal Riset Daerah Vol 26 No 1 (2026): JURNAL RISET DAERAH
Publisher : Badan Perencanaan Pembangunan Daerah Kabupaten Bantul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64730/jrdbantul.v26i1.159

Abstract

Infertility is a significant reproductive health problem that affects individuals and couples worldwide. Low public awareness regarding lifestyle-related infertility risk factors may lead to delays in prevention efforts and seeking healthcare services. This study aimed to evaluate the effectiveness of a lifestyle education intervention delivered through an e-book in improving knowledge regarding infertility risk factors among reproductive-age individuals in Bantul Regency. This study employed a quasi-experimental design with a one-group pretest–posttest approach involving 102 male and female respondents aged 18–45 years from the general population recruited using a convenience sampling technique. Respondents completed a validated knowledge questionnaire consisting of 20 items before and after receiving the educational intervention. The intervention consisted of an e-book containing information about infertility, its risk factors, and healthy lifestyle practices that support reproductive health. Data were analyzed using descriptive statistics and paired t-test analysis to assess differences in knowledge scores before and after the intervention. The results showed that the mean knowledge score increased significantly from 11.28 ± 3.14 during the pretest to 16.74 ± 2.41 during the posttest (p < 0.001). Item-level analysis also demonstrated an increased proportion of correct responses, particularly regarding modifiable lifestyle factors such as smoking, obesity, alcohol consumption, and physical activity. These findings indicate that lifestyle education delivered through digital media is effective in improving knowledge regarding infertility risk factors among reproductive-age communities. The integration of digital health education into reproductive health promotion programs has the potential to increase public awareness and support infertility prevention efforts.
Prevalence and Risk Factors of Polycystic Ovary Syndrome among Adolescent Girls in Sanden District: A Cross-Sectional Screening Study Erna Yovi Kurniawati; Elin Noviasari
Jurnal Riset Daerah Vol 26 No 1 (2026): JURNAL RISET DAERAH
Publisher : Badan Perencanaan Pembangunan Daerah Kabupaten Bantul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64730/jrdbantul.v26i1.161

Abstract

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age and often begins during adolescence. Early manifestations such as menstrual irregularities, acne, and metabolic disturbances may indicate an increased risk of PCOS. However, community-based evidence regarding PCOS risk among adolescents remains limited, particularly in developing countries. This study aimed to assess the prevalence of PCOS risk and identify associated factors among adolescent girls in Sanden District. This observational analytic study used a cross-sectional design in accordance with the STROBE Statement. A total of 32 adolescent girls aged 15–19 years were recruited using purposive sampling. Data were collected using a structured questionnaire assessing menstrual history, acne, hirsutism, and family history, along with anthropometric measurements to determine body mass index (BMI). Descriptive statistics were used to summarize participant characteristics, while bivariate analysis using the Chi-square test or Fisher’s exact test was performed to identify factors associated with PCOS risk. The results showed that 28.1% of participants were classified as being at risk of PCOS based on screening indicators. Menstrual cycle irregularity and BMI were significantly associated with PCOS risk (p < 0.05), whereas acne, hirsutism, and family history did not show statistically significant associations. These findings indicate that a considerable proportion of adolescent girls in Sanden District may already exhibit early indicators associated with PCOS risk. Early screening focusing on menstrual irregularities and BMI may support the early identification and prevention of reproductive and metabolic complications associated with PCOS.
Co-Authors Elfrida Iriyani` Elin Noviasari Noor Pramono