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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Journal of Pharmaceutical and Sciences.
Perangin-Angin, Eka Lestari Br
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Efek Pemberian Kulit Jeruk Berastagi (Citrus Sinensis L) Secara Topikal Terhadap Perbaikan Luka Sayat Tikus Berdasarkan Jumlah Fibroblast dan Diameter Luka Sumantri, Dinda Triana; Natali, Oliviti; Lubis, Adhayani; Perangin-Angin, Eka Lestari Br; Jelita Siregar, Yohana Putri
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i11.62436

Abstract

Wound healing is a complex biological process involving cellular and tissue responses, including fibroblast formation and wound diameter closure. Berastagi orange peel extract (Citrus sinensis L.) contains flavonoids, tannins, and vitamin C, which play roles in anti-inflammatory, antioxidant, and collagen-stimulating processes, thus potentially accelerating wound healing. This study aimed to determine the effect of topical administration of Berastagi orange peel extract (Citrus sinensis L.) on the healing of incised wounds in rats based on fibroblast count and wound diameter. This research employed a quantitative analytic true experimental design with a post-test group design. Rats were divided into several treatment groups, namely gel base, 10% povidone iodine, and Berastagi orange peel extract gel (EEKJ) at concentrations of 40%, 60%, and 80%. The observed parameters were fibroblast count and wound diameter on day 0 and day 14. Data were analyzed using ANOVA followed by Post Hoc tests. The results showed an increase in fibroblast count and a greater reduction in wound diameter in the groups treated with EEKJ gel compared to the gel base control group. Compared to 10% povidone iodine, EEKJ gel also showed relatively comparable effects in accelerating wound healing. The 60% concentration demonstrated more optimal results in stimulating fibroblast proliferation and reducing wound diameter, although statistically, the differences between concentrations were not significant (p > 0.05). Topical administration of Berastagi orange peel extract proved effective in accelerating the healing process of incised wounds by increasing fibroblast count and reducing wound diameter. The 60% concentration was the most optimal compared to other concentrations, although the differences were not statistically significant.
Efektivitas Ekstrak Kulit Jeruk Berastagi (Citrus Sinensis L.) Yang Diberikan Secara Topikal terhadap Kadar Serum C-reactive Protein pada Luka Sayat Tikus Jantan (Rattus Norvegicus) Siregar, Yohana Putri Jelita; Natali, Oliviti; Lubis, Adhayani; Sumantri , Dinda Triana; Perangin-Angin, Eka Lestari Br
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1159

Abstract

Introduction: Cutaneous wounds in male rats (Rattus norvegicus) are widely used as models for wound-healing research. C-reactive protein (CRP) is an inflammatory biomarker that increases in response to injury. Berastagi orange peel extract (Citrus sinensis L.) is known for its anti-inflammatory properties; however, its effectiveness in reducing serum CRP levels in cutaneous wounds has not been extensively studied. Objective: This study aimed to evaluate the effectiveness of topically administered Berastagi orange peel extract on serum CRP levels in male rats with cutaneous wounds. Methods: A total of 25 male rats were divided into three groups: control, treatment with orange peel extract, and treatment with a standard ointment. Wounds were inflicted on the rats' backs, and treatments were administered for a few days. Serum CRP levels were measured using the ELISA method. Results: Results indicated that the group receiving Berastagi orange peel extract exhibited a significant reduction in CRP levels compared to the control group (p < 0.05). The standard ointment group also showed a reduction, but not as effectively as the orange peel extract. Conclusion: Berastagi orange peel extract significantly reduces serum C-reactive protein levels in male rats with cutaneous wounds. These findings support the use of natural extracts as alternatives in wound healing therapy.
Co-Authors Jelita Siregar, Yohana Putri Lubis, Adhayani Natali, Oliviti Siregar, Yohana Putri Jelita Sumantri , Dinda Triana Sumantri, Dinda Triana