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All Journal Indonesian Journal of Kidney and Hypertension Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Nico Aldrin Avesina
Unknown Affiliation
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Madu Sebagai Hepatoprotektor Dinilai dengan Enzim Transaminase Nico Aldrin Avesina; M. Ricky Ramadhian
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 2 No. 3 (2015): JURNAL AGROMEDICINE
Publisher : Fakultas Kedokteran Universitas Lampung

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Abstract

Hati adalah organ penting, dan kelenjar terbesar pada tubuh manusia. Hati memiliki beberapa fungsi seperti pengolahan metabolik, detoksifikasi obat, dan tempat pengeluaran bakteri. Pada beberapa tahun terakhir kasus penyakit hati kronis semakin meningkat. Beberapa contoh kasus penyakit hati kronis yaitu hepatitis B, hepatitis C, hepatitis alkoholik, dan non alkoholik fatty liver. Penyakit hati kronis dan bahan toksik yang masuk ke hati dapat menyebabkan kerusakan sel hati, dimana kerusakan ini dapat dinilai dari pemeriksaan biokimiawi hati yaitu enzim aminotransaminase. Pada biokimiawi hati peningkatan enzim aminotransferase seperti alanine aminotransferase (ALT) dan aspartate aminotransferase (AST) biasanya sebagai penanda yang mengarah pada perlukaan hepatoseluler atau inflamasi. Selama beberapa tahun terakhirpenggunaan madu pada berbagai patologi sudah berkembang. Madu memiliki efek sebagai antioksidan, antibakteri, antiinflamasi, stimulasi imun, anti ulserasi, dan memiliki efek penyembuhan luka atau luka bakar. Pada beberapa penelitian madu juga memiliki efek hepatoprotekor sehingga dapat mempengaruhi perubahan pada enzim penanda kerusakan hati yaitu ALT dan AST. [J Agromed Unila 2015; 2(3):321-325]Kata kunci: ALT, AST, hati, madu
Diagnostic Challenge of Cardiorenal Involvement in Active Systemic Lupus Erythematosus: Sandra Yuliana Andini Putri; Nico Aldrin Avesina; Kuntjoro Harimurti
Indonesian Journal of Kidney and Hypertension Vol 3 No 2 (2026): Volume 3 No. 2 August 2026
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v3i2.253

Abstract

Renal and cardiac involvement in active systemic lupus erythematosus (SLE) may pose a diagnostic challenge because clinical, serological, and histopathological findings do not always correlate. A 20-year-old woman with a history of SLE presented with edema, foamy urine, decreased urine output, arthralgia, oral ulcers, and orthopnea. Laboratory and imaging findings revealed severe proteinuria, hematuria, urinary casts, hypocomplementemia, elevated serum creatinine, heart failure with reduced ejection fraction with an ejection fraction of 37%, pericardial effusion, and cardiomegaly. Kidney biopsy demonstrated class III+V lupus nephritis, with an activity index of 8/24, chronicity index of 8/12, fibrous and fibrocellular crescents each found in 1 of 5 viable glomeruli, and 60% interstitial fibrosis/tubular atrophy. Immunofluorescence showed granular deposition of IgG, IgA, IgM, C3, and C1q. Although the clinical course resembled rapidly progressive glomerulonephritis, the non-dominant crescentic lesions made “rapid decline in kidney function” a more appropriate term than classic RPGN. Cardiac dysfunction may represent suspected myocardial involvement, volume overload, anemia, uremia, or a combination of these factors. Kidney biopsy and integrated cardiac evaluation are essential for assessing disease activity, chronicity, and prognosis in cardiorenal involvement of active SLE.
Co-Authors Kuntjoro Harimurti M. Ricky Ramadhian Sandra Yuliana Andini Putri