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Pramudito, Ignatius Aditya Haryo
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Gut-Brain Axis in Type 2 Diabetes: A Review of Microbial Mechanisms and Clinical Implications Goenadi , Emmanuel Adrian; Pramudito, Ignatius Aditya Haryo; Saputra, Petra Heinson Handoyo; Bararinda, Pradipta Putramachristy; Priskila, Loury
MEDICINUS Vol. 38 No. 12 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/g87wm568

Abstract

The understanding of Type 2 Diabetes Mellitus (T2DM) is evolving beyond traditional risk factors to recognize the Gut Microbiota (GM) as a pivotal player in its pathogenesis. This narrative review illuminates the critical role of the Gut-Brain Axis (GBA), detailing how microbial dysbiosis—characterized by a loss of butyrate-producing bacteria—drives the systemic inflammation and insulin resistance central to T2DM. This paper provides an overview of microbiota-based interventions (probiotics, prebiotics, FMT) and explore the synergistic impact of physical activity, which not only enhances insulin sensitivity but also beneficially modulates the GM. The evidence indicates that an integrated approach, combining targeted microbial modulation with regular physical activity, represents a powerful therapeutic strategy for improving glucose homeostasis in T2DM.
Co-Authors Bararinda, Pradipta Putramachristy Goenadi , Emmanuel Adrian Priskila, Loury Saputra, Petra Heinson Handoyo