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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan MEDIC MEdical Dedication Journal of Comprehensive Science Makara Journal of Health Research MEDICINUS International Journal of Cell and Biomedical Science Jurnal Penelitian Keperawatan Cermin Dunia Kedokteran
Priskila, Loury
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Exploration The Multifaceted Role Of Vitamins In Epigenetic Regulation: Insights Into DNA Methylation And Histone Modification Perkasa, Tengku Arief Buana; Puspasari, Anggelia; Priskila, Loury; Tarigan, Nadir Putra Indra; Widyawati, Dwi; Neldi, Vina
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.42536

Abstract

Background: Recent research shows that vitamins actively regulate epigenetic mechanisms like DNA methylation and histone changes. Gene regulation, cellular differentiation, and disease development depend on these pathways. Aims: This review aims to synthesize current evidence on how vitamins A, B, C, D, E, and K influence epigenetic regulation, and to elucidate their potential roles in health maintenance and disease prevention. Methods: NCBI and ScienceDirect were used to search English-language literature from 2015 to 2024 for a narrative review. To capture vitamins' direct and indirect impacts on epigenetic pathways, selected peer-reviewed papers were qualitatively examined. Results: Vitamin A affects gene expression via receptor-mediated mechanisms which modify chromatin structure. B vitamins provide methyl donors for DNA methylation and histone changes. Vitamin C cofactors TET enzymes and histone demethylases, supporting active DNA demethylation and histone acetylation. The vitamin D receptor (VDR) affects DNA methyltransferases and histone-modifying enzymes, regulating gene transcription. Vitamins E and K modulate oxidative stress and histone changes to stabilize the epigenome, which may benefit cancer treatment and metabolic regulation. Conclusion: Vitamins' diverse and linked epigenetic regulatory activities are highlighted.  These micronutrients may help prevent and treat cancer, metabolic problems, and developmental anomalies by maintaining genomic integrity and influencing gene expression. Keywords: Vitamins, Epigenetics, DNA Methylation, Histone Modification, Nutritional Epigenetics, Gene Expression.
MEDICAL EMERGENCY EXPO: A COMMUNICATION BLUEPRINT FOR PUBLIC PREPAREDNESS IN INDONESIA Sira, Amaze Grace; Kristiyanto, Haryo Dimasto; Priskila, Loury
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 1 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Abstract

Based on BNPB data in 2024, there were 3,472 disasters in Indonesia, with the highest incidence being hydrometeorological disasters, which was 99.34% and geological disasters, 0.66% of the hydrometeorological disasters that occurred were floods and forest fires, in addition, there were 15 earthquakes and eight volcanic eruptions. In addition to natural disasters, emergencies often happen and claim many lives. According to data from the National Police Traffic Corps, throughout 2023, there were more than 150,000 cases of traffic accidents throughout Indonesia, with the death toll reaching more than 25,000 people. Method: This exhibition was held for 1 day by raising various topics related to disasters and emergencies in Indonesia. This activity not only invited the entire academic community of the Faculty of Medicine, Duta Wacana Christian University, but was also open to the public. Around 300 people attended this event, including UKDW students from medicine, other faculties, and the general public. All participants showed enthusiasm for this expo, from listening to the education provided to watching various theatrical performances and doing (hands-on) the mannequins or tools provided. The part organized by our tutorial group ran smoothly overall. All visitors showed enthusiasm in organizing the activity and participated in the entire series of activities. Keywords: communication strategy, disaster mitigation, emergency, medical, exhibition
The Role of Systemic Immune-Inflammation Index on The Clinical Degree of Dengue Hemorrhagic Fever Patients at Bethesda Hospital Yogyakarta Amumpuni, Antonia Namelia Wahyu; Sooai, Christiane Marlene; Wicaksono, Hendi; Probowati, Wiwiek; Priskila, Loury
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/y6daha15

Abstract

Background: Dengue hemorrhagic fever (DHF) is a mosquito-borne infectious disease caused by the dengue virus and transmitted primarily by Aedes aegypti. According to the World Health Organization (WHO), DHF remains a major globalhealth concern, particularly in tropical and subtropical regions. The disease can result in severe complications, including hemorrhage and hypovolemic shock, which may lead to death. Despite ongoing vector control initiatives, DHF continues to pose a significant public health challenge, especially in areas with inadequate sanitation and limited healthcare infrastructure.Objectives: To evaluate the role of systemic immune-inflammation index (SII) in determining the clinical severity of denguehemorrhagic fever (DHF) among patients at Bethesda Hospital Yogyakarta.Methods: This was a cross-sectional study utilizing medical records from 333 DHF patients at Bethesda Hospital Yogyakarta. Records were screened based on predefined inclusion and exclusion criteria. A total of 172 eligible cases were selected using odds ratio-based sample size calculations. Consecutive sampling was employed as the samplingtechnique. Data analysis was performed using SPSS and Microsoft Excel to determine statistical significance.Results: The findings demonstrated that neutrophil, lymphocyte, and platelet counts significantly influenced the clinical severity of dengue hemorrhagic fever (DHF). Chi-square analysis revealed a statistically significant association between the systemic immune-inflammation index (SII) and disease classification (DF/DHF) (p<0.001). However, the relationshipbetween SII levels and clinical severity did not follow a linear pattern. Contrary to established theories—where elevated SII values are typically associated with increased disease severity—this study observed variations that may be attributed toconfounding factors such as patient age, comorbidities, and individual immune response.Conclusion: The systemic immune-inflammation index (SII) is significantly associated with the clinical severity of DHF in patients at Bethesda Hospital Yogyakarta, although its correlation may be influenced by additional patient-specificvariables such as patient age, comorbidities, and individual immune responses.Keywords: systemic immune-inflammation index (SII), dengue hemmorhagic fever (DHF), dengue severity, clinicalseverity.
Strategies For Controlling Diabetes Mellitus In Adolescents Through A Family Approach At Puskesmas After The Covid-19 Pandemic Sira, Amaze Grace; Priskila, Loury; Simanjuntak, Mario Hendrian; Nappoe, Angela Aletha Biatrix; Helena, Dayceline
Journal of Comprehensive Science Vol. 4 No. 8 (2025): Journal of Comprehensive Science
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v4i8.3542

Abstract

Non-communicable diseases (NCDs) have become a burden on the health system in Indonesia in recent years. The increasing prevalence of diseases such as heart disease, diabetes mellitus, and cancer has an impact on national health financing, and people's quality of life. This study is a literature review that aims to evaluate the relationship between NCD risk factors, the impact of the COVID-19 pandemic on early detection of chronic diseases, and the role of primary health facilities and family approaches in controlling NCDs. Methods Secondary data were obtained from various scientific journals and official reports through systematic searches in Clinical Key, Google Scholar, and PubMed. Discussion The review showed that risk factors such as body mass index (BMI), unhealthy diet, low physical activity, and family history significantly contributed to the increase in NCD cases. The COVID-19 pandemic has also caused serious disruptions to preventive health services, including decreased access to early detection of Type 2 Diabetes Mellitus Programs such as Posbindu PTM and PIS-PK conducted by Puskesmas have an important role in promotive and preventive efforts, although they are still faced with various obstacles. The family approach in implementing healthy living behaviors and early detection has proven crucial in supporting the success of NCD control. Conclusion: The integration of the family approach in the national NCD control strategy needs to be strengthened to improve the effectiveness of interventions and the quality of life of the community.
Association Between Neutrophil-to-Lymphocyte Ratio (NLR) and Dengue Severity in Patients Treated at Bethesda Hospital, Yogyakarta Jingan, Forensius; Christiane Marlene Sooai; Loury Priskila; Pradita Sri Mitasari; Wiwiek Probowati; Priskila, Loury
MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/11a64f98

Abstract

Background: Dengue fever, a mosquito borne viral infection, remains a major public health concern in Indonesia, with the challenges in early identification of severe cases. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potentialbiomarker for assessing the disease severity.Objective: This study aimed to investigate the association between NLR and dengue severity in patients treated at Bethesda Hospital, Yogyakarta.Methods: A cross-sectional, quantitative study was conducted using medical record data from dengue patients admitted between 2022 to 2024. The NLR values were calculated from complete blood count results and disease severity was classified according to WHO guidelines. Statistical analysis was performed using the chi-square test and Fisher’s exact test.Results: Among the 68 patient samples, a significant association was found between NLR and dengue severity (p<0.001). Patients with lower NLR values were more likely to develop dengue hemorrhagic fever (DHF) compared to those with higher NLR values.Conclusion: The NLR plays a role in determining the severity of dengue infection and may serve as a predictive biomarker. This examination can be a practical tool in the clinical management of dengue fever patients, particularly for early detectionand optimizing therapeutic decision-making.
MENINGKATKAN PENGETAHUAN GIZI DAN MEMBERDAYAKAN KADER POSYANDU: PENDEKATAN STRATEGIS UNTUK PENCEGAHAN STUNTING DI PUSKESMAS SEDAYU, BANTUL, YOGYAKARTA Wicaksono, Hendi; Priskila, Loury; Jhonatan, Mikha; Gasri, Orynta Srikurnia; Patabang, Angreini Feshia
Jurnal Penelitian Keperawatan Vol 11 No 2 (2025): Jurnal Penelitian Keperawatan
Publisher : STIKES RS Baptis Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32660/jpk.v11i2.865

Abstract

Stunting merupakan masalah kesehatan yang masih menjadi tantangan besar di Indonesia, dengan angka kejadian mencapai 21,5% pada tahun 2023. Di Daerah Istimewa Yogyakarta, prevalensinya mencapai 18%, sedangkan di Kabupaten Bantul mencapai 20,5%. Sehingga peran kader posyandu menjadi krusial dalam edukasi dan pemantauan pertumbuhan anak sebagai bagian dari upaya pencegahan stunting. Penelitian ini bertujuan untuk menilai tingkat pengetahuan, motivasi, dan kinerja kader dalam upaya pencegahan stunting di wilayah kerja Puskesmas Sedayu II, Kabupaten Bantul, DI Yogyakarta. Penelitian ini menggunakan desain cross-sectional dengan dua kelompok responden, yaitu 72 kader aktif di Posyandu dan 52 orangtua/wali balita yang rutin mengunjungi Posyandu. Pengukuran dilakukan menggunakan kuisioner untuk menilai tingkat pengetahuan, motivasi, dan kinerja kader. Analisis data mencakup uji bivariat untuk menguji hubungan antara variabel-variabel yang dianalisis. Mayoritas kader berusia dewasa akhir (76,4%) dan memiliki pendidikan menengah (93,1%). Sebanyak 94,4% kader telah aktif lebih dari tiga tahun. Hasil analisis menunjukkan bahwa 71,1% kader memiliki tingkat pengetahuan yang baik, 42,2% memiliki motivasi yang baik, dan 96,2% memiliki kinerja yang baik. Uji bivariat menunjukkan tidak adanya hubungan signifikan antara usia, pendidikan, pekerjaan, dan motivasi dengan tingkat pengetahuan kader. Namun, terdapat perbedaan signifikan antara rata-rata tingkat pengetahuan dan kinerja kader (p=0,001). Hasil penelitian ini menunjukan mayoritas kader di Puskesmas Sedayu II memiliki tingkat pengetahuan dan kinerja yang baik, namun motivasi kader masih perlu ditingkatkan. Peningkatan kapasitas kader melalui pelatihan dan pendampingan rutin sangat diperlukan untuk meningkatkan efektivitas mereka dalam pencegahan stunting.
Strategies for Controlling Diabetes Mellitus in Adolescents through a Family Approach at Puskesmas after the COVID-19 Pandemic Sira, Amaze Grace; Priskila, Loury; Wicaksono, Hendi; Simanjuntak, Mario Hendrian; Nappoe, Angela Aletha Biatrix; Julianto, Dayceline Helena
International Journal of Cell and Biomedical Science Vol 3 No 8 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i8.56

Abstract

Background Non-communicable diseases (NCDs) have become a burden on the health system in Indonesia in recent years. The increasing prevalence of diseases such as heart disease, diabetes mellitus, and cancer has an impact on national health financing, and people's quality of life. This study is a literature review that aims to evaluate the relationship between NCD risk factors, the impact of the COVID-19 pandemic on early detection of chronic diseases, and the role of primary health facilities and family approaches in controlling NCDs. Methods Secondary data were obtained from various scientific journals and official reports through systematic searches in Clinical Key, Google Scholar, and PubMed. Discussion The review showed that risk factors such as body mass index (BMI), unhealthy diet, low physical activity, and family history significantly contributed to the increase in NCD cases. The COVID-19 pandemic has also caused serious disruptions to preventive health services, including decreased access to early detection of Type 2 Diabetes Mellitus Programs such as Posbindu PTM and PIS-PK conducted by Puskesmas have an important role in promotive and preventive efforts, although they are still faced with various obstacles. The family approach in implementing healthy living behaviors and early detection has proven crucial in supporting the success of NCD control. Conclusion: The integration of the family approach in the national NCD control strategy needs to be strengthened to improve the effectiveness of interventions and the quality of life of the community.
Kajian Manfaat Diet Mediterania: Analisis Priskila, Loury; Perkasa, Tengku Arief Buana; Wijaya, Yogik Onky Silvana
Cermin Dunia Kedokteran Vol 51 No 11 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i11.1265

Abstract

The rapid growth of nutrigenomics and nutrigenetics has greatly contributed to understanding the importance of genetic, nutrition, and environmental interaction in maintaining human health. Healthy lifestyles such as adequate physical activity and healthy diet patterns have been widely reported may reduce the risk of various diseases. One of the health diet patterns that has been widely studied is the Mediterranean diet (MedDiet). MedDiet is a plant-based diet pattern high in fiber, high in unsaturated fatty acids, and low in meat and dairy products. This literature study aims to summarize the health benefits of the MedDiet pattern and its biomechanisms.
Literature Review: The Iceberg Phenomenon in Hyperthyroidism and Mental Disorders Priskila, Loury; Dinata, Fenita Renny; Danuartha, Made Anom; Tamma, Haryadi Aristo; Herlambang, Yosafat Reza
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 2 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i2.43494

Abstract

Background: Elevated thyroid hormone levels have a high prevalence this year. It has a long-term impact on the cognitive and productivity of sufferers, leading to a decrease in the quality of life of individuals and an increase in social and economic burden. Previous studies have shown a direct link between hyperthyroidism and mental disorders, but the impact on cognitive and emotional functioning still needs to be clarified. Early detection and management are the main challenges in preventing and treating this condition. Methods: Our study was a literature review of medical journal for the last 10 years through NCBI, Google Scholar, Clinicalkey, Semantic Scholar, Sciencedirect, and Springer. Result: Hyperthyroidism caused by dysregulation of the Hypothalamic-Pituitary-Thyroid axis that disrupts the balance of triiodothyronine and thyroxine hormones, leading to emotional and cognitive impairment. The brain and thyroid tissue are also affected by the FDPS, PPIL3, MMAB, and ALDH2 genes, which are characterized by significant expression in areas of brain function that are involved in cognitive, emotional, and social behaviour. Conclusion: A multidisciplinary approach, including pharmacological therapy, cognitive therapy, and community education, is an important step in reducing the impact of hyperthyroidism on mental health as well as social and economic aspects.
The Gut-Brain Axis in Type 2 Diabetes: A Review of Microbial Mechanisms and Clinical Implications Goenadi , Emmanuel Adrian; Pramudito, Ignatius Aditya Haryo; Saputra, Petra Heinson Handoyo; Bararinda, Pradipta Putramachristy; Priskila, Loury
MEDICINUS Vol. 38 No. 12 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/g87wm568

Abstract

The understanding of Type 2 Diabetes Mellitus (T2DM) is evolving beyond traditional risk factors to recognize the Gut Microbiota (GM) as a pivotal player in its pathogenesis. This narrative review illuminates the critical role of the Gut-Brain Axis (GBA), detailing how microbial dysbiosis—characterized by a loss of butyrate-producing bacteria—drives the systemic inflammation and insulin resistance central to T2DM. This paper provides an overview of microbiota-based interventions (probiotics, prebiotics, FMT) and explore the synergistic impact of physical activity, which not only enhances insulin sensitivity but also beneficially modulates the GM. The evidence indicates that an integrated approach, combining targeted microbial modulation with regular physical activity, represents a powerful therapeutic strategy for improving glucose homeostasis in T2DM.
Co-Authors Amumpuni, Antonia Namelia Wahyu Anggelia Puspasari Anggitama, Andreas Mercyan Atmadi, Lenggana Relung Bagaskara, Arya Taksya Bararinda, Pradipta Putramachristy Cahyani, Ni Kade Dian Ary Christiane Marlene Sooai Christiane Marlene Sooai, Christiane Marlene Danuartha, Made Anom Dinata, Fenita Renny Gasri, Orynta Srikurnia Goenadi , Emmanuel Adrian Helena, Dayceline Hendi Wicaksono Herlambang, Yosafat Reza Jhonatan, Mikha Jingan, Forensius Julianto, Dayceline Helena Kristiyanto, Haryo Dimasto Loury Priskila Nappoe, Angela Aletha Biatrix Neldi, Vina Patabang, Angreini Feshia Pradita Sri Mitasari Pramudito, Ignatius Aditya Haryo Probowati, Wiwiek Saputra, Petra Heinson Handoyo Sasabone, Ahava Tasa Simanjuntak, Mario Hendrian Sira, Amaze Grace Tamma, Haryadi Aristo Tarigan, Nadir Putra Indra Tengku Arief Buana Perkasa Widyawati, Dwi Wiwiek Probowati Yeckopradana, Ebenezer Devara Yogik Onky Silvana Wijaya