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p-Index From 2021 - 2026
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This Author published in this journals
All Journal The Journal of Society Medicine (JSOCMED) Media of Health Research
Okafor, Chinedu
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Knowledge Level of Pregnant Women About Oral and Dental Health During Pregnancy Manu, Apri Adiari; Ngadilah, Christina; Eluama, Merniwati Sherly; Horo, Yohana Safira; Okafor, Chinedu
Media of Health Research Vol. 1 No. 2 (2023): Media of Health Research, August 2023
Publisher : Lembaga Publikasi Ilmiah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/mohr.v1i2.17

Abstract

Pregnancy is a physiological process that causes changes in a woman's body followed by hormonal changes, which not only affect general health but also affect oral and dental health. The purpose of this study was to determine the level of knowledge of pregnant women about oral health during pregnancy. The method used is descriptive method with a total sample taken of 28 pregnant women. Data collection was carried out by giving questionnaires to respondents to answer the questions given. The level of knowledge of pregnant women in Tuak Daun Merah Village (TDM) includes good criteria (41%), moderate criteria (50%) and bad criteria (9%). The level of knowledge about how to brush the teeth of pregnant women in the TDM Village with good criteria (39%), moderate criteria (47%), bad criteria (14%) this is because there are still pregnant women who do not know the time, frequency and how to brush their teeth properly. good and right. The level of knowledge about the diet of pregnant women in TDM Village with good criteria (75%), moderate criteria (21%), bad criteria (4%). The highest knowledge is with good criteria, the reason is by watching television and reading on the internet so that respondents understand and answer questions about eating patterns correctly. The level of knowledge about dental health control for pregnant women in the TDM Village with good criteria (10%), moderate criteria (61%), bad criteria (29%) this is because respondents know the time of dental health control but have not routinely carried out dental health control to medical facility.
Gut Microbiota–Driven Modulation of Host Immune Responses in Severe Infections: Mechanistic Insights and Translational Implications Bello, Fatima; Okafor, Chinedu
Journal of Society Medicine Vol. 5 No. 3 (2026): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v5i3.268

Abstract

Introduction: Severe infections, particularly sepsis and ICU-acquired infections, remain leading causes of global morbidity and mortality, primarily driven by dysregulated host immune responses. Increasing evidence positions the gut microbiota as a critical regulator of systemic immunity through bidirectional host–microbiome interactions, functioning not merely as a passive microbial reservoir but also as an active determinant of disease progression and clinical outcomes. Methods: A structured narrative synthesis was conducted using literature retrieved from PubMed, Embase, and Cochrane Library. Priority was given to high-quality randomized controlled trials, large observational cohorts, and mechanistic preclinical studies published within the past 10–15 years. Evidence was systematically appraised using standardized risk-of-bias frameworks, including Cochrane tools, and integrated into a translational model linking microbiome alterations with host immune dynamics. Results: Severe infections were consistently associated with rapid-onset gut dysbiosis, characterized by reduced microbial diversity and expansion of opportunistic pathogens. Five principal mechanistic domains were identified: immune system modulation, disruption of epithelial barrier integrity, altered microbial metabolite signaling, systemic microbial translocation, and antibiotic-induced ecological imbalance. Although observational data demonstrate strong associations between dysbiosis and adverse outcomes, interventional studies targeting the microbiome have reported heterogeneous efficacy, reflecting the underlying biological complexity and current therapeutic limitations. Conclusion: Gut microbiotas represent a dynamic and potentially modifiable regulator of host immune responses during severe infections. Future research should emphasize causal inference, precision microbiome-based interventions, and the integration of multi-omics approaches to develop mechanism-based therapeutic strategies and clinically actionable biomarkers to improve outcomes in critically ill patients.
Co-Authors Bello, Fatima Eluama, Merniwati Sherly Horo, Yohana Safira MANU, APRI ADIARI Ngadilah, Christina