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All Journal Medicinus : Jurnal Kedokteran Jurnal Biomedika dan Kesehatan
Widyatmiko, Himawan
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Mengungkap Potensi Platelet-Rich Plasma untuk Meningkatkan Kualitas Hidup Pasien dengan Nyeri Punggung Bawah: Sebuah Tinjauan Literatur Sasongko, Muhammad Gagas; Ramadhan, Dwiky Ananda; Luwito, Jeffry; Latumahina, Jonathan; Widyatmiko, Himawan; Witarto, Andro Pramana
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Low back pain (LBP) is a widespread issue that affects many people globally, causing significant limitations in daily activities and work. LBP imposes a considerable economic burden due to healthcare costs and lost productivity. This review explores platelet-rich plasma (PRP) therapy, a promising treatment because of its ability to regenerate tissues. PRP contains growth factors that stimulate cell activity and collagen production, which can significantly reduce pain and enhance mobility and quality of life for LBP sufferers. PRP's capacity to aid in tissue repair and decrease inflammation suggests it could be beneficial for these various causes. Compelling clinical studies have demonstrated that PRP can dramatically reduce pain and disability, offering patients renewed hope and improved outcomes. Additionally, PRP therapy is minimally invasive with rare and mild side effects, underscoring its safety and efficacy. This review underscores the urgent need for further research to refine PRP treatment protocols and confirm long-term benefits. Large-scale randomized controlled trials are essential to develop standardized guidelines and ensure consistent, positive results across diverse patient populations. PRP therapy represents a revolutionary approach to managing LBP, promising to address the root causes and deliver lasting relief rather than merely masking symptoms. The future of LBP treatment could be significantly improved through the widespread adoption of PRP therapy.
Efficacy and Safety of Stem Cell Therapy for Spinal Cord Injury in Adults: A Systematic Review and Meta-Analysis Rhadika, Anadya; Romano, Sultan Adhitya; Widyatmiko, Himawan; Tanuwijaya, Andrew Wilbert; Putra, Putu Surya Pradipta Hariantha; Amanah, Salma Rizqi; Elashry, Abdelrahman Ramadan; Javaid, Sarmad; Inggas, Made Agus Mahendra; Wijaya, Jeremiah Hilkiah
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10762

Abstract

Background: Despite encouraging early results, clinical outcomes remain inconsistent across trials. This study aimed to systematically evaluate the efficacy and safety of stem cell therapy in adults with spinal cord injury (SCI). Methods: A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. PubMed, EMBASE, and Scopus were searched until 18 October 2025. Eligible studies included adult SCI patients receiving stem cell therapy with measurable neurological outcomes. Data synthesis was performed using Review Manager 5.4 under a random-effects model, reporting pooled risk ratios (RR) with 95% confidence intervals (CIs). Risk of bias was assessed using ROBINS-I, and evidence certainty was graded via GRADE. Result: Thirteen studies involving 470 participants (286 intervention, 184 control) were included. Stem cell therapy significantly improved neurological recovery compared with controls (RR = 2.64; 95% CI 1.70–4.10; p < 0.0001; I² = 0%). Subgroup analyses showed consistent benefits across baseline AIS classifications (RR = 2.61; 95% CI 1.71–3.98) and cell doses (RR = 2.75; 95% CI 1.63–4.64). No major safety signals were identified. GRADE assessment rated the certainty of efficacy evidence as moderate. Conclusions: Stem cell therapy yields significant neurological improvement in adult SCI with a favorable safety profile. The findings support its regenerative potential through neuroprotective and remyelinating mechanisms. However, larger randomized controlled trials are required to validate efficacy, optimize protocols, and assess long-term safety.
Co-Authors Amanah, Salma Rizqi Elashry, Abdelrahman Ramadan Javaid, Sarmad Latumahina, Jonathan Luwito, Jeffry Made Agus Mahendra Inggas, Made Agus Mahendra Putra, Putu Surya Pradipta Hariantha Ramadhan, Dwiky Ananda Rhadika, Anadya Romano, Sultan Adhitya Sasongko, Muhammad Gagas Tanuwijaya, Andrew Wilbert Wijaya, Jeremiah Hilkiah Witarto, Andro Pramana