<![CDATA[Currently, the use of mesenchymal stem cells (MSCs) in cell therapy is growing as a means to repair damaged cells. MSCs are multipotent stem cells that can differentiate into a variety of specialized cell types in various tissues. Adipose tissue, bone marrow, umbilical cord, and placenta are possible sources of MSCs. MSCs produce various bioactive molecules, called secretome that have effects on skin cells by mediating growth factors and cytokines. MSCs can actively contribute to wound healing through several phases, including promoting fibroblast migration, neovascularization, secreting anti-inflammatory cytokines, and re-epithelialization. To improve therapeutic effectiveness, appropriate biomaterials on nanofiber scaffolds were created to mimic the natural extracellular matrix and attract fibroblasts into the skin layer. The purpose of this review is to evaluate the research on the utilization of MSCs with various nanofiber scaffolds in the wound healing process in vitro. The result of this review is that there are several natural and synthetic polymers used as scaffold materials that are biocompatible, thus increasing the healing potential of wound tissue. MSCs when co-cultured in nanofiber scaffolds activate several mechanism pathways, such as expressing genes or growth factors related to wound healing. It is concluded that the utilization of biopolymers in MSC-seeded scaffold designs can contribute to the enhancement of wound healing and tissue regeneration.]]>
