Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Jurnal Biologi Tropis
Putri, Monica Indiasti
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Future Acne Therapy MSC Secretome as an Antimicrobial Agent: Literature Review Putri, Monica Indiasti; Marlina, Marlina; Sudji, Ikhwan Resmala
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10622

Abstract

Acne vulgaris is a chronic inflammatory skin condition influenced by excess sebum production, bacterial colonization, and host immune responses. Microorganisms, particularly Cutibacterium acnes and Staphylococcus aureus, play a key role in acne pathogenesis and contribute to persistent inflammation. With increasing antibiotic resistance, innovative therapeutic approaches that are effective, safe, and immunomodulatory are urgently required. This literature review aims to evaluate the role of adipose-derived mesenchymal stem cell (ADMSC) secretome in inhibiting acne-causing bacteria. The review was conducted using databases including ResearchGate, PubMed, Google Scholar, and ScienceDirect, using keywords such as secretome, MSC secretome, antibacterial, C. acnes, S. aureus, and acne vulgaris. A total of 13 relevant research articles were identified. The ADMSC secretome contains antimicrobial peptides (e.g., LL-37), cytokines, growth factors, and extracellular vesicles that can disrupt bacterial membranes, enhance phagocytosis, and inhibit biofilm formation. Several studies demonstrate strong inhibitory effects against S. aureus, including resistant strains, while data on C. acnes remains limited but still supports its therapeutic relevance.
Co-Authors Ikhwan Resmala Sudji Marlina Marlina