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All Journal Jurnal Biologi Tropis Jurnal Pijar MIPA
Irgi, Khaeru
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Mathematics Physics

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Probiotic Gummies for Improving Gut Microbiota and Nutritional Status in Stunted Children: A Narrative Review Rusmayanti, Agustina; Kasasiah, Ahsanal; Irgi, Khaeru
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10708

Abstract

Stunting remains a major nutritional problem in Indonesia and is often linked to gut microbiota imbalance that can limit nutrient absorption and weaken intestinal function. This article reviews evidence on how probiotics can support gut health and examines the potential of gummy formulations that children can consume easily. The review process used Publish or Perish to search scientific articles from 2016 to 2025 in Google Scholar, PubMed and Scopus. Titles, abstracts and full texts were screened to ensure relevance. A total of 17 studies were included in the analysis. The findings show that probiotics can increase SCFA-producing bacteria, improve the gut mucosal barrier and support the absorption of minerals such as calcium and iron. Several studies also report better digestive comfort and improved microbiota diversity after probiotic intake. Probiotic gummies show good stability, maintain viable cells and are well accepted by children, which makes them a practical delivery system. The evidence from these 17 studies suggests that probiotic gummies have potential to support gut health and contribute to stunting prevention. Longer studies are still needed to measure their direct impact on child growth and guide future nutritional interventions.
Factors Associated with FMT Failure in Clostridioides difficile Infection and Age-Related Considerations: A Review Irgi, Khaeru; Kasasiah, Ahsanal; Rusmayanti, Agustina
Jurnal Pijar Mipa Vol. 20 No. 8 (2025): Special Issue
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i8.10558

Abstract

Clostridioides difficile infection (CDI) is a major cause of nosocomial diarrhea worldwide, and limitations of standard antibiotic therapy have driven the adoption of fecal microbiota transplantation (FMT) as an alternative therapeutic approach. Although FMT achieves clinical success in most patients, treatment failure still occurs in a considerable proportion of cases. Existing literature has examined overall FMT efficacy, yet no review has comprehensively synthesized the multifactorial determinants of FMT failure while incorporating age-related considerations. This narrative review provides an integrative overview of factors contributing to FMT failure in adults with CDI. A literature search of PubMed and Google Scholar identified original research articles published between 2015 and 2025. Evidence indicates that FMT failure is influenced by host-related factors such as comorbidities, immune function, and nutritional status; disease-related characteristics, including CDI severity and recurrence history; technical aspects, such as bowel preparation, donor type, and route of administration; and pharmacological factors, including antibiotic exposure before or after the procedure. These factors collectively affect donor microbiota engraftment and increase the risk of therapeutic failure. Age-related physiological and microbiome changes may additionally modify treatment responses. This review highlights the need for comprehensive patient assessment, standardized procedural protocols, and careful post-FMT monitoring. Addressing current evidence gaps and improving clinical guidance will be essential for optimizing the safety and effectiveness of FMT across different adult age groups.
Co-Authors Ahsanal Kasasiah Rusmayanti, Agustina