Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Narra J
Khairan Khairan
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Effectiveness of Sialang Honey in Burn Healing Through the Expression of Vascular Endothelial Growth Factor (VEGF) in Rattus norvegicus Firdath Rubenzani; Syamsul Rizal; Mirnasari Amirsyah; Budiman Budiman; Khairan Khairan
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.24978

Abstract

Full-thickness burns require rapid revascularization to prevent tissue necrosis and support the healing process. Sialang honey, a wild multifloral honey from Indonesia, has traditionally been used for wound care, but its specific mechanism in modulating angiogenesis remains poorly understood. This study aimed to evaluate the effectiveness of Sialang honey on the expression of Vascular Endothelial Growth Factor (VEGF) in a mouse model with full-thickness burns. A true experimental study with a post-test only control group design was conducted using 27 male Wistar rats (Rattus norvegicus). Full-thickness burns were induced and treated daily for 14 days. Rats were randomly divided into three groups: Negative Control (0.9% NaCl), Treatment (Topical Sialang Honey), and Positive Control (1% Silver Sulfadiazine). Skin tissue was collected on days 5, 7, and 14. VEGF expression was detected using immunohistochemical (IHC) staining and measured via H-Score. Data were analyzed using One-Way ANOVA and Post-Hoc LSD Test (p<0.05). Treatment with Sialang Honey significantly increased VEGF expression compared to the negative control group. Peak expression occurred on day 7 (mean difference vs. control: p=0.000), indicating strong angiogenesis during the proliferation phase. Notably, VEGF levels in the honey group decreased significantly on day 14 (p<0.05), mimicking the physiological transition to the remodeling phase. The honey group showed a superior angiogenic response compared to Silver Sulfadiazine on day 7. Sialang honey effectively accelerated burn wound healing by modulating VEGF expression promoting an initial surge in angiogenesis followed by a physiological decline. These findings support the potential of Sialang honey as an effective topical agent for burn management. Keywords: Sialang Honey, Vascular Endothelial Growth Factor (VEGF), Angiogenesis.
Development and preclinical evaluation of an Aceh kelulut honey-based hydrocolloid dressing for wound healing Muhammad IA. Putra; Khairan Khairan; Izza Chairani; Binawati Ginting; Kartini Hasballah; Reno K. Kamarlis; Mudatsir Mudatsir; Syamsul Rizal; Mirnasari Amirsyah; Muhammad Diah
Narra J Vol. 6 No. 2 (2026): August 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i2.3121

Abstract

Honey has long been used in wound care because of its antibacterial and anti-inflammatory properties, while hydrocolloid dressings provide a moist and protective environment that supports tissue repair. This study aimed to evaluate the macroscopic and microscopic effects of an Aceh kelulut honey–based hydrocolloid dressing on wound healing in mice. Twenty-seven healthy male mice (Mus musculus) were assigned to three groups: control treated with 0.9% NaCl, pure Aceh kelulut honey (KH), and Aceh kelulut honey–based hydrocolloid (KHHC). Two full-thickness excisional wounds, each 4 mm in diameter, were created on the dorsal skin of each mouse. Wound diameter was measured daily for 14 days. Histopathological evaluation was performed on days 3, 7, and 14 to assess neutrophil and macrophage counts, epithelialization ratio, myofibroblast ratio, and collagen fiber density. The KHHC group showed faster macroscopic wound closure than the KH and control groups. Significant differences were observed among groups in neutrophil count, macrophage count, epithelialization ratio, myofibroblast ratio, and collagen fiber density. KHHC reduced inflammatory cell infiltration, increased myofibroblast ratio, and enhanced collagen fiber density, suggesting accelerated wound contraction and tissue remodeling. However, epithelialization was lower in the KHHC group during the early healing phase. These findings indicate that Aceh kelulut honey–based hydrocolloid dressing may improve several key aspects of wound healing, particularly inflammation control, wound contraction, and collagen deposition. Further studies are required to optimize the formulation and clarify its effect on reepithelialization.
Co-Authors Binawati Ginting Budiman Budiman Firdath Rubenzani Izza Chairani Kartini Hasballah Mirnasari Amirsyah Mirnasari Amirsyah Mudatsir Mudatsir Muhammad Diah Muhammad IA. Putra Reno K. Kamarlis Syamsul Rizal Syamsul Rizal