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All Journal Pharmacia Jurnal Kesehatan Tujuh Belas (Jurkes TB)
Ratna Fitry Yenny
Universitas Sultan Ageng Tirtayasa Banten
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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FORMULASI SEDIAAN HAND BODY LOTION ANTIPENUAAN DARI KOMBINASI TANAMAN KOMODITAS HORTIKULTURA EKSTRAK BUAH PEPAYA DAN STROBERI DALAM MENGHAMBAT ENZIM TIROSINASE Firman Rezaldi; Vevi Maritha; Muhammad Faizal Fathurrohim; Andri Tri Cahyono; Dyah Rohmawati; Sukardi Sugeng Rahmad; Roni Gumilar; Ratna Fitry Yenny
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 4 No. 1 (2022): November 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

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Abstract

One of the long-term losses in homeostatic balance in every living creature is a sign of aging skin. Hyperpigmentation conditions caused by the activity of the tyrosinase enzyme are an indicator of aging. One of the solutions that can be applied to prevent premature signs of aging is skin care using the most affordable pharmaceutical preparation, namely Hand Body Lotion. Hand Body Lotion which has anti-aging properties can be produced from bioactive compounds from horticultural commodity plants because it has been proven and is quite popular. Apart from being able to be used as an active ingredient in functional food, it can also be recommended as a pharmaceutical, namely the preparation of active cosmetic ingredients. This is because the content of vitamins, antioxidants, essential oils, proteins, even phenolic compounds and other active ingredients which are quite environmentally friendly can be produced from horticultural commodity plants, especially in the fruit group used in this research. Strawberry fruit has been reported to contain organic compounds such as gallic acid, elagic acid, and ferulic acid which can inhibit the melanogenesis process both in vitro and in vivo from previous findings. Papaya fruit contains saponins, flavonoids, alkaloids and tannins so it can be designed to inhibit the tyrosinase enzyme. This research aims to determine the inhibitory power of the tyrosinase enzyme from horticultural commodity plant extracts, both strawberries and papaya, in the form of formulations and hand body lotion preparations. The results of this research have proven that based on the IC50 value of horticultural commodity plant extracts, papaya has better inhibitory power for the tyrosinase enzyme compared to strawberries, namely 8,875 µg/mL. The conclusion in this research is that horticultural commodity plants in the form of papaya fruit extract are more recommended as an active ingredient in inhibiting the tyrosinase enzyme when compared with strawberry fruit extract based on the IC50 value even though in the form of hand body lotion it has the potential to inhibit the tyrosinase enzyme.
Antifungi Tanaman Komoditas Hortikultura Spesises Cabai Rawit Pada Formulasi Dan Sediaan Spray Kombucha Bunga Telang Dan Bunga Kecombrang Sebagai Produk Bioteknologi Pertanian Dan Farmasi Firman Rezaldi; Roni Gumilar; Agan Syahrial; Tri Yudianto; Ratna Fitry Yenny; Usman Setiawan
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 5 No. 2 (2025): Mei
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

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Abstract

Horticultural commodity plants are commodities that play an important role in meeting food needs, one of which is red chili. One of the weaknesses of horticultural products is that they are easily damaged, have a short shelf life, and are easily contaminated by pathogenic fungi. Pathogenic fungi that have the potential to contaminate red chili plants include Colletotrichum capsicii, Cercospora capsici, and Phytophthora capsici. The solution to overcome the epidemiology of contamination of these three pathogenic fungi is by utilizing the fermentation waste of kombucha from butterfly pea flowers and torch ginger flowers in the form of formulations and spray preparations. This study aims to compare spray waste from butterfly pea flowers and torch ginger flowers at concentrations of 20%, 30%, and 40% in inhibiting the growth of the three pathogenic fungi for red chili plants. This study is an experimental laboratory study which provides Na.CMC as a negative control and the antibiotic ketonazole as a positive control then provides fermentation waste from butterfly pea flowers and torch ginger flowers in concentrations of 20%, 30%, and 40%. The inhibition test was carried out through disc diffusion. Data analysis was carried out through one way ANOVA. The results of the study based on one way ANOVA test at each P value <0.05 continued with post hoc test has proven that kombucha waste of butterfly pea and torch ginger flowers at a concentration of 40% is not significantly different from 20% and 30% as an antifungal Colletotrichum capsicii, Cercospora capsici, and Phytophthora capsici. The conclusion in this study is that kombucha waste of butterfly pea flowers at all concentrations is higher when compared to kombucha waste of torch ginger flowers as a product of agricultural and pharmaceutical biotechnology and antifungal.
FORMULASI SEDIAAN ODOL KOMBUCHA BUNGA TELANG SEBAGAI PRODUK BIOTEKNOLOGI FARMASI DAN ANTIMIKROBA (Staphylococcus aureus, Streptococcus mutan, Candida albicans).Telang flower kombucha has been widely studied as a probiotic drink that can boost the immune s Firman Rezaldi; Yuliana Kolo; Ratna Fitry Yenny; Vevi Maritha; Novi Ayuwardani; Andri Tri Cahyono; Fitria Eka Resti Wijayanti; Rifkarosita Putri Ginaris; Reni Purbanova
PHARMACIA Vol. 2 No. 2 (2024): Pharmacy
Publisher : Program Studi Farmasi Universitas Mulia

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Abstract

Telang flower kombucha has been widely studied as a probiotic drink that can boost the immune system which in recent research has various pharmacological activities as a source of antimicrobials, especially in health problems related to dental disease. Previous studies and this is still a renewable research has found that mouthwash formulations and preparations made from an active ingredient of seagrass kombucha fermented solution have been shown to be able to inhibit the growth of Staphylococcus aureus, Candida albicans, and Streptococcus mutans. This study aims to make toothpaste formulations and preparations with an active ingredient of telang flower kombucha fermented solution as a pharmaceutical biotechnology product designed to inhibit the growth of Staphylococcus aureus and mutant Streptococcus bacteria as well as pathogenic fungi in the form of Candida albicans species. This type of research is a laboratory experiment in which we make a toothpaste base without the active substance as a negative control. Provide toothpaste that is sold in the market as a positive control. Make formulations and preparations of toothpaste with active ingredients from the fermented butterfly pea flower kombucha solution which includes concentrations of 20%, 30% and 40%. Data analysis was used through one way ANOVA where in the results of the study each preparation had a P value <0.05, so that further tests could be carried out through post hoc analysis. eggplant at a concentration of 40% was significantly different from 20% and 30% as a pharmaceutical biotechnology product in inhibiting the growth of the three test microbes and the results of this study it can be concluded that the formulation and preparation of toothpaste made from the active ingredient of butterfly pea flower kombucha fermentation solution is the best treatment as an antimicrobial and pharmaceutical biotechnology products.
Co-Authors Agan Syahrial Andri Tri Cahyono Andri Tri Cahyono Dyah Rohmawati Fitria Eka Resti Wijayanti Muhammad Faizal Fathurrohim Novi Ayuwardani Reni Purbanova Rifkarosita Putri Ginaris Roni Gumilar Sukardi Sugeng Rahmad Tri Yudianto Usman Setiawan Vevi Maritha Yuliana Kolo