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Tri Yudianto
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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DAYA HAMBAT ENZIM TIROSINASE DARI FORMULASI SEDIAAN HAND SANITZER GEL SEBAGAI ANTIAGING BERBAHAN AKTIF TANAMAN KOMODITAS HORTIKULTURA BERUPA KOMBINASI EKSTRAK BUAH NAGA MERAH DAN BUAH LEMON Tri Yudianto; Arti Wahyu Utami; Rifkarosita Putri Ginaris; Nai’matul Retno Faizah; Octaviana Dyah Oentari; Alfina Nurrahman; Fitria Eka Resti Wijayanti; Sukardi Sugeng Rahmad; Reni Purbanova
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 4 No. 1 (2022): November 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

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Abstract

One of the long-term losses in homeostatic balance for any organism is a sign of aging skin. The state of hyperpigmentation caused by the activity of the tyrosinase enzyme is an indicator of aging. The solution that can be recommended to prevent premature signs of aging is by caring for the skin using the most affordable pharmaceutical preparation, namely Hand Sanitizer Gel. Hand Sanitizer Gel which has anti-aging properties can be produced from bioactive compounds from horticultural commodity plants because it has been proven and is quite popular. Apart from being able to be used as an active ingredient in functional food, it can also be used as a pharmaceutical, namely the preparation of active cosmetic ingredients. This is due to the content of vitamins, antioxidants, essential oils, proteins, even phenolic compounds and other environmentally friendly active ingredients found in horticultural commodity plants, especially the fruit group used in this research. Red dragon fruit has been proven to contain organic compounds such as gallic acid, elagic acid and ferulic acid which can inhibit the melanogenesis process both in vitro and in vivo from the results of previous findings. Lemons contain saponins, flavonoids, alkaloids and tannins so they can be designed to inhibit the tyrosinase enzyme. This research aims to determine the inhibitory power of the tyrosinase enzyme from extracts of horticultural commodity plants, both red dragon fruit and lemon peels in the form of hand sanitizer gel formulations and preparations. The results of this research have proven that based on the IC50 value, horticultural commodity plant extracts from lemon peel have better inhibitory power for the tyrosinase enzyme compared to red dragon fruit, namely 3,509 µg/mL. The conclusion in this research is that horticultural commodity plants in the form of lemon peel extract are more recommended as an active substance in inhibiting the tyrosinase enzyme when compared with red dragon fruit extract based on the IC50 value even though the hand sanitizer gel dosage form has the potential to inhibit the tyrosinase enzyme.
Antifungi Tanaman Komoditas Hortikultura Spesises Cabai Rawit Pada Formulasi Dan Sediaan Spray Kombucha Bunga Telang Dan Bunga Kecombrang Sebagai Produk Bioteknologi Pertanian Dan Farmasi Firman Rezaldi; Roni Gumilar; Agan Syahrial; Tri Yudianto; Ratna Fitry Yenny; Usman Setiawan
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 5 No. 2 (2025): Mei
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

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Abstract

Horticultural commodity plants are commodities that play an important role in meeting food needs, one of which is red chili. One of the weaknesses of horticultural products is that they are easily damaged, have a short shelf life, and are easily contaminated by pathogenic fungi. Pathogenic fungi that have the potential to contaminate red chili plants include Colletotrichum capsicii, Cercospora capsici, and Phytophthora capsici. The solution to overcome the epidemiology of contamination of these three pathogenic fungi is by utilizing the fermentation waste of kombucha from butterfly pea flowers and torch ginger flowers in the form of formulations and spray preparations. This study aims to compare spray waste from butterfly pea flowers and torch ginger flowers at concentrations of 20%, 30%, and 40% in inhibiting the growth of the three pathogenic fungi for red chili plants. This study is an experimental laboratory study which provides Na.CMC as a negative control and the antibiotic ketonazole as a positive control then provides fermentation waste from butterfly pea flowers and torch ginger flowers in concentrations of 20%, 30%, and 40%. The inhibition test was carried out through disc diffusion. Data analysis was carried out through one way ANOVA. The results of the study based on one way ANOVA test at each P value <0.05 continued with post hoc test has proven that kombucha waste of butterfly pea and torch ginger flowers at a concentration of 40% is not significantly different from 20% and 30% as an antifungal Colletotrichum capsicii, Cercospora capsici, and Phytophthora capsici. The conclusion in this study is that kombucha waste of butterfly pea flowers at all concentrations is higher when compared to kombucha waste of torch ginger flowers as a product of agricultural and pharmaceutical biotechnology and antifungal.
Co-Authors Agan Syahrial Alfina Nurrahman Arti Wahyu Utami Firman Rezaldi Fitria Eka Resti Wijayanti Nai’matul Retno Faizah Octaviana Dyah Oentari Ratna Fitry Yenny Reni Purbanova Rifkarosita Putri Ginaris Roni Gumilar Sukardi Sugeng Rahmad Usman Setiawan