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All Journal Buletin Veteriner Udayana
Luh Made Sudimartini
Laboratorium Farmakologi dan Farmasi Veteriner, Fakultas Kedokteran Hewan Universitas Udayana, Jl. PB. Sudirman, Depasar, Bali, Indonesia, 80234
Immunology & microbiology Public Health Veterinary

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THE EFFECT OF GIVING NATURAL GUARD ESSENTIAL OIL IN DRINKING WATER ON BLOOD UREA NITROGEN LEVELS, CREATININE, AND AMINOTRANSFERASE IN BROILERS Muhamad Abdul Shidiq; Ida Bagus Komang Ardana; I Ketut Sumadi; I Made Merdana; Luh Made Sudimartini; Yousef Haig Setrak Babikian; Haig Yousef Babikian; Rubiyanto Widodo Haliman; Kristina; Theng In Yen; Hendi Yanto Efendy
Buletin Veteriner Udayana Bul. Vet. Udayana. February 2024 Vol. 16 No. 1
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bvu.v16i1.66

Abstract

To increase growth and feed efficiency, we can use feed additives through feed or drinking water, one of which is the use of essential oils. NATURALGUARD is  a mixture of natural oils, namely pine oil (Pinus sp.), lavender (Lavandula sp.), and eucalyptus oil (Eucalyptus sp.) which contains active compounds as immunomodulators, antibacterials, antioxidants, anti-inflammatory, antifungal and antiviral. This study aims to determine the level of Blood Urea Nitrogen (BUN), Creatinine, Aspartate Aminotransferase (AST), and Alanine Aminotransferase (ALT) in broilers after being given NATURALGUARD via drinking water. This study used a completely randomized design with a total sample of 24 broiler CP-707 strain, with four treatments and six replications. The treatment applied was P0 as a control without giving NATURALGUARD, P1 P2, and P3 were given NATURALGUARD at doses of 1, 2, and 4 g/L respectively, adlibitum for 30 days. At the end of the study, 3 mL of blood sample was taken via the pectoral vein aseptically, and then a blood serum examination was carried out. The research results showed that the highest mean BUN level was at P0 (8.9 mg/dL) and the lowest was at P1 (5.2 mg/dL), the highest creatinine was at P3 (1.08 mg/dL) and the lowest was at P0 and P1 (1, 0 mg/dL), AST was highest at P0 (273 µ/L) and lowest at P2 (220 µ/L), and ALT was highest at P0 (7.5 µ/L) and lowest at P3 (5.48 µ/ L). Statistical results showed no significant differences in BUN, creatinine, AST, and ALT levels in all treatment groups. It was concluded that NATURALGUARD as feed additive at doses of 1, 2, and 4 g/L via drinking water is safe to be used in broilers.
THE AKUT TOXICITY TESTING LETHAL DOSE ORAL GREEN MENIRAN LEAF EXTRACT BY USING MICE Ni Kadek Eka Widiadnyani; Luh Made Sudimartini
Buletin Veteriner Udayana Bul. Vet. Udayana. February 2024 Vol. 16 No. 1
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bvu.v16i1.71

Abstract

The use of a dose limit of green meniran leaf extract (Phylanthus niruri Linn) must be known for its safety which is supported by research results. The aims of this research to determine the acute lethal dose (LD50) toxicity and to examine the macropathological changes in the vital organs of mice. A total of 30 male mice and 30 female mice were divided into five groups and six replicates. Experimental mice in the control group (K) were given 0.9% NaCl, while those given meniran extract at doses of 50, 300, 2000 and 5000mg/KgBW were grouped as treatments. The preparation was given orally once and then the observations were made in the first 30 minutes after giving the preparation and periodically every 4 hours for the first 24 hours and once a day then the mice were observed for clinical symptoms, mortality and body weight. At the end of the study (day 14), the experimental mice were sacrificed for macropathological evaluation. giving meniran extract orally up to a dose of 5000 for 14 days did not cause death or showed toxic symptoms and normal growth. On macropathological examination of size, color and consistency, all organs were in normal condition. Green meniran leaf extract preparations > 5000 mg/kgBW are practically non-toxic and didn’t cause organ abnormalities. It is necessary to do research on toxicity, biocompatibility, effects, and potential for subchronic toxicity to changes in histopathological structure with a longer study duration, higher doses and more varied dosage ranges.
Co-Authors Haig Yousef Babikian Hendi Yanto Efendy I Ketut Sumadi I Made Merdana Ida Bagus Komang Ardana Kristina Muhamad Abdul Shidiq Ni Kadek Eka Widiadnyani Rubiyanto Widodo Haliman Theng In Yen Yousef Haig Setrak Babikian