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All Journal Buletin Veteriner Udayana
I Made Merdana
Laboratorium Farmakologi dan Farmasi Veteriner, Fakultas Kedokteran Hewan, Universitas Udayana, Jl. P.B Sudirman, Denpasar, Bali, Indonesia
Immunology & microbiology Public Health Veterinary

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THE EFFECT OF GIVING BLOCK GAMAL LEAF ON BLOOD GLUCOSE LEVELS OF BALI CATTLE ANESTRUS Mary Renata Devi Natalivia; Samsuri; I Made Merdana; Luh Made Sudimartini; I Nyoman Sulabda; Anak Agung Sagung Kendran
Buletin Veteriner Udayana Bul. Vet. Udayana. August 2024 Vol. 16 No. 4
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2024.v16.i04.p07

Abstract

Anestrus is a condition in female animals that do not show symptoms of estrus for a long period of time. Anestrus is a frequent cause of infertility in cows. Gamal leaves in the cow's rumen are expected to optimize the fermentation process so that they can increase volatile fatty acids (VFA). The expected total VFA product increases the propionate ratio. Increasing the propionate ratio has an effect on increasing gluconegenesis in the liver, resulting in an increase in blood glucose. This study aims to determine the impact of administering gamal leaf blocks on blood glucose levels of Bali cattle experiencing anestrus. This research used 6 anestrus Bali cattle as objects selected using purposive sampling. The six cows were given block treatment for 2 weeks. After sampling was carried out on the 10th day after treatment and the 20th day after treatment, the results showed that administering a gliricidia leaf block for 14 days had no significant effect on increasing blood glucose levels in anestrus Bali cattle.
ISTOPATHOLOGY OF THE BRAIN OF WHITE RATS UPON ADMINISTRATION OF MIMOSIN FROM SIMPLISIA OF LEUCAENA LEAVES Yuyun Setia Ningsih; I Ketut Berata; Ni Luh Eka Setiasih; I Made Kardena; Samsuri; I Made Merdana
Buletin Veteriner Udayana Bul. Vet. Udayana. June 2025 Vol. 17 No. 3
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i03.p46

Abstract

Lamtoro (Leucaena leucocephala) is a widely used cattle feed in Indonesia due to its high protein, flavonoid, and tannin content. However, it contains mimosine, a compound whose effects on the liver remain poorly understood. This study aimed to investigate the histopathological effects of mimosine on the liver of experimental animals. Twenty male Wistar rats (Rattus norvegicus), aged 2 months (150–200 g), were divided into four groups: a negative control (P0), a positive control given pure mimosine (5 mg/head/day, P1), and two groups administered mimosine from lamtoro leaf simplisia at 50 mg/head/day (P2) and 150 mg/head/day (P3). Treatments were administered orally for 14 days. On day 15, liver samples were collected, fixed in 10% neutral buffered formalin (NBF), and processed for histopathological analysis using hematoxylin-eosin (H&E) staining. Lesions (congestion, inflammation, and necrosis) were scored on a scale of 0 (normal) to 3 (severe). Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. Results showed that pure mimosine (5 mg) and lamtoro simplisia (50 mg and 150 mg) induced significant hepatic congestion compared to controls, while inflammation was not statistically significant. Necrosis was not observed in any group. No significant difference was found between the two doses of lamtoro simplisia. These findings suggest that mimosine, whether pure or derived from lamtoro leaves, induces mild to moderate liver damage, primarily congestion, but further research is needed to clarify its long-term effects.
ACUTE DERMAL IRRITATION TEST OF SIMPLISIA BUNGA GUMITIR OINTMENT ON ALBINO RABBIT Wayan Sangi Vani; I Made Merdana; I Wayan Gorda
Buletin Veteriner Udayana Bul. Vet. Udayana. June 2025 Vol. 17 No. 3
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i03.p33

Abstract

Marigold (Tagetes erecta L.) are widely cultivated for ornamental purposes and also as a natural food coloring. Gumitir flowers contain antioxidants, secondary metabolites such as terpenoids, essential oils, flavonoids, and carotenoids. This study aims to determine the results of the acute dermal irritation test of the simplicia flower gumitir ointment on albino rabbits, referring to The OECD Guideline for Testing of Chemicals - No. Test: 404, Acute Dermal Irritation/Corrosion (OECD) 2015. The test animals, consisting of three albino rabbits (Oryctolagus cuniculus), were treated with the simplicia flower gumitir ointment, with a placebo (negative control) as a comparison, using the patch test technique and evaluation based on the Amanded Draize test. The research results show that the application of gumitir flower simplicia ointment does not cause erythema and edema, both in the treatment and control groups, with a Mean Irritation Index of 0.16. Observation of reversibility effects showed the growth of fine and normal hair around the test area. It can be concluded that the gumitir flower simplicia ointment is non-irritating and therefore safe to use. It is recommended to conduct further tests as an effort to improve the salve made from gumitir flower simplicia, including salve formulation, stability testing, safety testing, and a review of previous test data.
Co-Authors Anak Agung Sagung Kendran I Ketut Berata I Made Kardena I Nyoman Sulabda I Wayan Gorda Luh Made Sudimartini Mary Renata Devi Natalivia Ni Luh Eka Setiasih Samsuri Wayan Sangi Vani Yuyun Setia Ningsih