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All Journal Jurnal EduHealth
Ratih Arum Astuti
Pharmacy Study Program, Faculty of Applied Science, Muhammadiyah University of Education
Health Professions Public Health Veterinary

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Antioxidant Activity Test of Peel-off Mask of Ethanol Extract of Kitolod Leaves (Isotoma Longiflora L) Nur Indah Sari; Angga Bayu Budiyanto; Ratih Arum Astuti
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Free radicals are one of the main causes of skin cell damage, resulting in premature aging. Antioxidants play an important role in neutralizing free radicals, thereby maintaining skin health. Kitolod leaves (Isotoma longiflora L.) are known to contain flavonoids, alkaloids, saponins, and polyphenols that have antioxidant potential. This study aims to formulate 70% ethanol extract of kitolod leaves into a peel-off gel mask preparation and evaluate its physical stability and antioxidant activity. The research method is experimental with variations in extract concentration of 5%, 10%, and 15%. Physical evaluation of the formulation included organoleptic testing, homogeneity, pH, viscosity, spreadability, adhesion, and drying time, while antioxidant activity was tested using the DPPH method. The results showed that all formulations met the characteristics of a good peel-off mask preparation and remained stable for 14 days of storage. The antioxidant activity test using the method showed that the IC50 value of kitolod leaf extract was 52.84 ppm, which is classified as strong. Thus, the peel-off gel mask containing kitolod leaf extract has the potential to be developed as a natural cosmetic product with good antioxidant activity.
Analgesic Activity Test of Carrot (Daucus carota L.) Peel Extract on White Mice Lintang Kumala Rahayu; Ratih Arum Astuti; Angga Bayu Budiyanto
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Pain is an unpleasant experience characterized by potential tissue damage. One plant that has the potential to inhibit pain through its chemical compounds, namely flavonoids and alkaloids, is carrot peel (Daucus carota L.). The purpose of this study was to determine the analgesic activity of carrot peel extract in male mice. Carrot peel was extracted using the maceration method with 96% solvent. This study used 15 mice as test animals, which were divided into 5 treatment groups, namely the negative control group (CMC-Na), the positive control group (Sodium Diclofenac), carrot peel extract 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW. The test was conducted using the tail flick method with an analgesia measuring device. The test was conducted using the tail flick method with an analgesia measuring device. The data obtained were then analyzed using a paired sample t-test. The results showed that the three doses of carrot peel ethanol extract, 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW, did not have analgesic activity in male mice.
Co-Authors Angga Bayu Budiyanto Lintang Kumala Rahayu Nur Indah Sari