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All Journal Edu Society: Jurnal Pendidikan, Ilmu Sosial dan Pengabdian Kepada Masyarakat Journal of Pharmaceuticals and Natural Sciences
Jasimah, Jasimah
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences Other

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Pemanfaatan Video Pembelajaran Materi Bumi dan Antariksa sebagai Media Digital di SDN Simpang Tiga Jasimah, Jasimah; Sari, Siti Mayang
EDU SOCIETY: JURNAL PENDIDIKAN, ILMU SOSIAL DAN PENGABDIAN KEPADA MASYARAKAT Vol. 5 No. 3 (2025): Oktober 2025 - Januari 2026
Publisher : Association of Islamic Education Managers (Permapendis) Indonesia, North Sumatra Province

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56832/edu.v5i3.2418

Abstract

Pemanfaatan media digital dalam pembelajaran di sekolah dasar menjadi upaya untuk meningkatkan kualitas proses belajar mengajar. Video pembelajaran merupakan media digital yang mampu menyajikan materi secara visual dan audio sehingga memudahkan peserta didik dalam memahami konsep pembelajaran. Penelitian ini bertujuan mendeskripsikan pemanfaatan video pembelajaran materi Bumi dan Antariksa sebagai media digital di SD Negeri Simpang Tiga. Metode penelitian yang digunakan adalah kualitatif deskriptif. Subjek penelitian terdiri dari guru dan siswa SD Negeri Simpang Tiga. Teknik pengumpulan data dilakukan melalui observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa pemanfaatan video pembelajaran materi Bumi dan Antariksa mampu meningkatkan minat belajar siswa, membantu pemahaman konsep yang bersifat abstrak, serta mempermudah guru dalam menyampaikan materi. Kesimpulan yang diperoleh adalah video pembelajaran dapat dimanfaatkan secara efektif sebagai media digital dalam pembelajaran IPA di sekolah dasar.
Uncovering Anti-Obesity Candidates from Robusta Green Coffee: In Silico Evaluation of Bioactive Compounds Targeting PPAR-α Mahardika, Bintang Satrio; Putri, Viona Algesia Fiola; Putri, Yolla Adellia; Jasimah, Jasimah; Gabriel, Kevin; Rusdin, Agus; Novitasari, Dhania
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.40

Abstract

Obesity arises from a chronic imbalance between energy intake and expenditure, leading to excessive accumulation of body fat. Peroxisome proliferator-activated receptor-alpha (PPARα) plays a key regulatory role in lipid metabolism, particularly in reducing the de novo synthesis of fatty acids. Robusta coffee has been widely consumed as part of the lifestyle, yet scientific evidence for its pharmacological effects is limited. This study aimed to evaluate the molecular interactions between secondary metabolites from Green Bean Coffee Robusta (Coffea canephora P.) and PPARα using in silico approaches. The workflow included screening compounds from C. canephora based on Lipinski’s Rule of Five (RO5) and ADMET predictions, followed by pharmacophore modelling and molecular docking simulations using AutoDock against PPARα (PDB ID: 2P54). All the bioactive constituents in C. canephora met the requirements of RO5, and several metabolites were assessed based on their pharmacokinetic profile and toxicology prediction. Further molecular docking analysis identified 4-ethyl-2-methoxyphenol as the most promising anti-obesity candidate, demonstrating the lowest binding energy (-4.58 kcal/mol) and an inhibition constant of 440.47 µM. The compound formed key hydrogen bonds with amino acid residues ALA333, THR279, CYS276, and CYS275. These findings suggest that 4-ethyl-2-methoxyphenol from Green Bean Coffee Robusta exhibits potential as an anti-obesity agent through its interaction with the PPARα receptor. Further in vitro and in vivo studies are required to validate its pharmacological effects.
Co-Authors Gabriel, Kevin Mahardika, Bintang Satrio Novitasari, Dhania Putri, Viona Algesia Fiola Putri, Yolla Adellia Rusdin, Agus Siti Mayang Sari