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Pribadi , Florence
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Eksplorasi Efek Hidrasi Lotion Yang Diperkaya Dengan Ekstrak Clitoria Ternatea Pada Kulit Mus Musculus Yang Terpapar Sinar UV Prabowo, Cheryl; Pribadi , Florence; Mellyanawati, Mellyanawati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1218

Abstract

This study aimed to evaluate the effectiveness of a lotion enriched with butterfly pea flower extract (Clitoria ternatea) in improving skin hydration in mice (Mus musculus) exposed to ultraviolet (UV) light. Butterfly pea flower extract is known to contain anthocyanins and phenolic compounds, which act as antioxidants and are thought to maintain skin moisture. The study design used an experimental method. Mice were randomly allocated into five groups (n = 6 per group), consisting of a negative control group, a positive control group, and three treatment groups receiving butterfly pea flower extract lotion at concentrations of 0.5%, 1%, and 2%.  Skin hydration levels were measured using a Scalar Moisture Checker after five minutes of UV exposure. The results showed a significant difference in hydration levels between groups. The 1% butterfly pea flower extract lotion showed a significant increase in skin hydration compared to the negative control (p < 0.05), indicating its optimal moisturizing efficacy among the tested formulations. These findings indicate that butterfly pea flower extract has potential as an active ingredient in lotion formulations to improve hydration in skin damaged by UV light exposure. This study provides a scientific basis for the use of butterfly pea flower extract as a natural moisturizing agent.
Analisis Efektivitas Nanocurcumin Terhadap Ekspresi TNF-α Dan Diameter Lesi Pada Mencit (Mus musculus) Yang Diinduksi Endometriosis Dharma, Komang Ayu Vanessa; Pribadi , Florence; Kusumah , Irwin Priyatna
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1249

Abstract

Endometriosis is a chronic gynecological disease characterized by the growth of endometrial-like tissue outside the uterus, which triggers local inflammation and lesion progression. The pathological process involves increased proinflammatory cytokines, including TNF-α, and activation of proliferative and angiogenic pathways. Nanocurcumin, with higher bioavailability compared to conventional curcumin, is known to have the potential to modulate inflammation and inhibit ectopic tissue growth. This study aimed to analyze the effect of nanocurcumin at a dose of 10 mg/kgBW on TNF-α expression and endometriosis lesion diameter in endometriosis-induced mice. The laboratory experimental study used a post-test only control group design with three treatment groups (control, nanocurcumin after induction, and nanocurcumin before induction), each consisting of 10 mice. TNF-α expression was measured using the ELISA method, while lesion diameter was assessed macroscopically. Data analysis was performed using the Shapiro–Wilk normality test, Levene's homogeneity test, ANOVA, and Tukey's extended test. The results showed no significant difference in TNF-α levels between groups (p = 0.933). However, there was a significant difference in endometriosis lesion diameter (p < 0.001), with the nanocurcumin group showing the greatest lesion shrinkage compared to the control and other treatment groups. Nanocurcumin significantly reduced the diameter of endometriosis lesions in mice, although it did not significantly reduce serum TNF-α levels. These findings suggest that the therapeutic effects of nanocurcumin may be mediated through local mechanisms that are not fully reflected in serum biomarkers.
Co-Authors Dharma, Komang Ayu Vanessa Kusumah , Irwin Priyatna Mellyanawati Mellyanawati Prabowo, Cheryl