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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Andi Utari Prasetya Ningrum
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Health Professions Nursing Public Health

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Uji Aktivitas Farmakologi Ekstrak Daun Jambu Air (Syzygium Samarangense)Terhadap Mencit (Mus Musculus) Resky Aulifiyah Haswari B; Nur Sahra; Masnaeni Thamrin; Silvia Astuti; Diva Sukrianingsih; Nurul Nisai; Nur Alya Nazifa; Alya Salsabila; Andi Utari Prasetya Ningrum
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 4 No. 1 (2026): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v4i1.944

Abstract

This study aims to determine the pharmacological activity profile of water apple (Syzygium samarangense) leaf extract on male mice (Mus musculus) and to observe the effect of increasing doses on its pharmacological classification. The screening method involved observing 25 parameters, including behavioral, autonomic, and motoric responses, using three concentration levels: 1%, 2%, and 4%. The results showed that the extract exhibited diverse pharmacological effects, with the Central Nervous System (CNS) stimulation and CNS depression being the most prominent activities at a 1% concentration. Interestingly, as the concentration increased, specific effects like parasympathomimetic activity remained consistently significant across all doses (ranging from 18.29% to 21.46%). The observed parasympathomimetic effects such as increased urination and defecation suggest that the extract may promote intestinal motility and bladder contraction. Additionally, the presence of sympathomimetic and parasympatholytic activities indicates a complex interaction with the autonomic nervous system. In conclusion, Syzygium samarangense leaf extract possesses potential as a parasympathomimetic agent, which could be further investigated for treating hypertension through vasodilation or as a diuretic and digestive aid. Further specific testing is required to isolate the active compounds responsible for these effects.
Profil Aktivitas Farmakologis Daun Pepaya Segar pada Sistem Saraf: Suatu Kajian Berdasarkan Perbedaan Konsentrasi Nurul Izzatul Jannah; Husnul Hatima; Dhiva Rabiatul Maulia; Nurazizah Khairani; Fauziah Zakilah; Rahasia Rahasia; Sisma Efendi; Nur Aulia; Muh.Yusuf Al Habib Rachman; Andi Utari Prasetya Ningrum
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2010

Abstract

The extract of Carica papaya L. leaves contains phytochemical compounds such as flavonoids, alkaloids, phenolics, and saponins that play a role in biological activities, including antioxidants, anti-inflammatory, analgesic, and modulation of the nervous system. This study aims to evaluate the effects of fresh papaya leaf extract on the central nervous system (CNS) and autonomic nervous system based on varying extract concentrations. The study used test animals with treatment groups consisting of negative control, positive control, and extracts at concentrations of 4%, 8%, and 16%. Parameters observed included parasympathomimetic (PSM), parasympatholytic (PSL), sympathomimetic (SM), sympatholytic (SL), analeptic effects (ANA), CNS stimulation (SSSP), CNS depression (DSSP), and muscle relaxation (RO). The results showed that the 16% concentration produced the highest PSM activity (46.82%) and dominant CNS stimulation (38.59%), while DSSP and RO decreased at higher concentrations. This phenomenon indicates that increasing the extract concentration does not always enhance CNS depression, but rather leads to stimulation. These findings support the potential of papaya leaf extract as a neuroprotective and multifunctional agent. Further research is needed to confirm its molecular mechanisms and clinical effectiveness as a phytotherapy candidate.
Evaluasi Aktivitas Farmakologi Simplisia Kopi Arabika (Coffea arabica) pada Berbagai Konsentrasi terhadap Sistem Saraf Otonom dan Sistem Saraf Pusat Anggun Aldiansa; Ilmi Nurashiilah; Nahla Aulia Azis; Nasifa Kayla Putri; Andi Tenriani Awaliyah; Ayu Azkiya; Aulya Nurul Imama R; Hilda Kadir; Muhammad Chairul Anam; Andi Utari Prasetya Ningrum
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2015

Abstract

Arabica coffee (Coffea arabica) contains various bioactive compounds such as caffeine, polyphenols, flavonoids, and alkaloids that have the potential to produce diverse pharmacological effects on both the autonomic and central nervous systems. The variation in its chemical composition is influenced by factors such as cultivar, post-harvest processing, and preparation methods, resulting in biological responses that are dose-dependent and not always linear. This study aimed to evaluate the pharmacological activity of arabica coffee simplicia powder at three concentrations (1%, 2%, and 4%) by observing parasympathomimetic, parasympatholytic, sympathomimetic, sympatholytic, analeptic, central nervous system stimulation and depression, as well as muscle relaxation parameters. The research was conducted using a laboratory experimental design with test animals administered orally according to the designated concentrations. The results showed that some parameters increased at higher concentrations, such as parasympathomimetic activity (51.85%) and central nervous system stimulation (63.74%), while other parameters demonstrated decreasing or biphasic patterns, such as sympatholytic activity, which was high at 1% and 4% but low at 2%, and analeptic activity, which dropped sharply at 2% and increased again at 4%. These response patterns align with literature indicating that caffeine and polyphenols such as chlorogenic acid may interact synergistically or antagonistically, generating complex pharmacological effects through mechanisms involving adenosine modulation, excitatory neurotransmitters, the enteric nervous system, as well as antioxidant and anti-inflammatory pathways. Overall, this study demonstrates that arabica coffee simplicia exhibits multipotential pharmacological activity, with responses strongly influenced by concentration and the composition of its bioactive compounds, thereby providing a basis for further research on the phytopharmaceutical potential of arabica coffee.
Co-Authors Alya Salsabila Andi Tenriani Awaliyah Anggun Aldiansa Aulya Nurul Imama R Ayu Azkiya Dhiva Rabiatul Maulia Diva Sukrianingsih Fauziah Zakilah Hilda Kadir Husnul Hatima Ilmi Nurashiilah Masnaeni Thamrin Muh.Yusuf Al Habib Rachman Muhammad Chairul Anam Nahla Aulia Azis Nasifa Kayla Putri Nur Alya Nazifa Nur Aulia Nur Sahra Nurazizah Khairani Nurul Izzatul Jannah Nurul Nisai Rahasia Rahasia Resky Aulifiyah Haswari B Silvia Astuti Sisma Efendi