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All Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Andi Utari Prasetya Ningrum
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Health Professions Nursing Public Health

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Profil Aktivitas Farmakologis Daun Pepaya Segar pada Sistem Saraf: Suatu Kajian Berdasarkan Perbedaan Konsentrasi Nurul Izzatul Jannah; Husnul Hatima; Dhiva Rabiatul Maulia; Nurazizah Khairani; Fauziah Zakilah; Rahasia Rahasia; Sisma Efendi; Nur Aulia; Muh.Yusuf Al Habib Rachman; Andi Utari Prasetya Ningrum
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2010

Abstract

The extract of Carica papaya L. leaves contains phytochemical compounds such as flavonoids, alkaloids, phenolics, and saponins that play a role in biological activities, including antioxidants, anti-inflammatory, analgesic, and modulation of the nervous system. This study aims to evaluate the effects of fresh papaya leaf extract on the central nervous system (CNS) and autonomic nervous system based on varying extract concentrations. The study used test animals with treatment groups consisting of negative control, positive control, and extracts at concentrations of 4%, 8%, and 16%. Parameters observed included parasympathomimetic (PSM), parasympatholytic (PSL), sympathomimetic (SM), sympatholytic (SL), analeptic effects (ANA), CNS stimulation (SSSP), CNS depression (DSSP), and muscle relaxation (RO). The results showed that the 16% concentration produced the highest PSM activity (46.82%) and dominant CNS stimulation (38.59%), while DSSP and RO decreased at higher concentrations. This phenomenon indicates that increasing the extract concentration does not always enhance CNS depression, but rather leads to stimulation. These findings support the potential of papaya leaf extract as a neuroprotective and multifunctional agent. Further research is needed to confirm its molecular mechanisms and clinical effectiveness as a phytotherapy candidate.
Evaluasi Aktivitas Farmakologi Simplisia Kopi Arabika (Coffea arabica) pada Berbagai Konsentrasi terhadap Sistem Saraf Otonom dan Sistem Saraf Pusat Anggun Aldiansa; Ilmi Nurashiilah; Nahla Aulia Azis; Nasifa Kayla Putri; Andi Tenriani Awaliyah; Ayu Azkiya; Aulya Nurul Imama R; Hilda Kadir; Muhammad Chairul Anam; Andi Utari Prasetya Ningrum
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2015

Abstract

Arabica coffee (Coffea arabica) contains various bioactive compounds such as caffeine, polyphenols, flavonoids, and alkaloids that have the potential to produce diverse pharmacological effects on both the autonomic and central nervous systems. The variation in its chemical composition is influenced by factors such as cultivar, post-harvest processing, and preparation methods, resulting in biological responses that are dose-dependent and not always linear. This study aimed to evaluate the pharmacological activity of arabica coffee simplicia powder at three concentrations (1%, 2%, and 4%) by observing parasympathomimetic, parasympatholytic, sympathomimetic, sympatholytic, analeptic, central nervous system stimulation and depression, as well as muscle relaxation parameters. The research was conducted using a laboratory experimental design with test animals administered orally according to the designated concentrations. The results showed that some parameters increased at higher concentrations, such as parasympathomimetic activity (51.85%) and central nervous system stimulation (63.74%), while other parameters demonstrated decreasing or biphasic patterns, such as sympatholytic activity, which was high at 1% and 4% but low at 2%, and analeptic activity, which dropped sharply at 2% and increased again at 4%. These response patterns align with literature indicating that caffeine and polyphenols such as chlorogenic acid may interact synergistically or antagonistically, generating complex pharmacological effects through mechanisms involving adenosine modulation, excitatory neurotransmitters, the enteric nervous system, as well as antioxidant and anti-inflammatory pathways. Overall, this study demonstrates that arabica coffee simplicia exhibits multipotential pharmacological activity, with responses strongly influenced by concentration and the composition of its bioactive compounds, thereby providing a basis for further research on the phytopharmaceutical potential of arabica coffee.
Co-Authors Andi Tenriani Awaliyah Anggun Aldiansa Aulya Nurul Imama R Ayu Azkiya Dhiva Rabiatul Maulia Fauziah Zakilah Hilda Kadir Husnul Hatima Ilmi Nurashiilah Muh.Yusuf Al Habib Rachman Muhammad Chairul Anam Nahla Aulia Azis Nasifa Kayla Putri Nur Aulia Nurazizah Khairani Nurul Izzatul Jannah Rahasia Rahasia Sisma Efendi