Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Health & Medical Sciences
Putri, Ersty Marthalia
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Differences in Glutathione Peroxidase (GPx) Levels Before and After Pulmonary Tuberculosis Treatment Putri, Ersty Marthalia; Anita Liliana Susanti; Deasy Wirasiti
Health & Medical Sciences Vol. 3 No. 1 (2025): November
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v3i1.557

Abstract

This study aimed to review changes in glutathione peroxidase or GPx levels or activity before and after pulmonary tuberculosis treatment. A systematic scoping review was conducted on articles published between 2016 and 2025 retrieved from Google Scholar, ScienceDirect, and PubMed. Article selection followed PRISMA guidelines and applied eligibility criteria based on the PICO framework. Six studies met the inclusion criteria and were included in the analysis. All reviewed studies reported changes in GPx levels or activity after tuberculosis treatment, with most showing an increase in GPx activity following anti-tuberculosis therapy. Several studies also reported that adjunct antioxidant interventions, such as N-acetylcysteine, contributed to enhanced glutathione system function and increased GPx activity compared to standard therapy alone. The observed increase in GPx activity was associated with reduced oxidative stress and improved redox balance during treatment. These findings indicate that GPx has potential as a biomarker for monitoring treatment response in pulmonary tuberculosis. However, variations in study design, sample size, and measurement methods were identified across the included studies. Further well-designed clinical studies with standardized GPx assessment protocols are needed to confirm its clinical utility and to clarify the role of antioxidant supplementation in supporting tuberculosis treatment outcomes.
Co-Authors Anita Liliana Susanti, Anita Liliana Deasy Wirasiti