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All Journal Usadha Journal of Creative Power and Ambition (JCPA)
Maria Malida Vernandes Sasadara
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Agriculture, Biological Sciences & Forestry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Produksi Ramah Lingkungan Granul Instan Antioksidan dari Kulit Jeruk Bali (Citrus maxima) Menggunakan Ekstraksi Berbantuan Enzim Yuda, Putu Era Sandhi Kusuma; Ni Kadek Lita; Adinda Puspita Elisabet Lian; Ni Putu Jayanti Putri; I Gusti Ayu Sri Candramukhi Devi Dasi; Intan Alfira Kolifay; Erna Cahyaningsih; Maria Malida Vernandes Sasadara
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i3.13155

Abstract

Pomelo peel (Citrus maxima) is an agricultural by-product rich in bioactive compounds, particularly flavonoids and phenolic compounds, which have potential antioxidant and anti-aging properties. However, the high pectin content in citrus peels can hinder the release of these active compounds. The objective of this study was to improve the extraction efficiency of bioactive compounds from pomelo peel using an environmentally friendly Enzyme-Assisted Extraction (EAE) method employing pectinase enzymes and to formulate the extract into instant effervescent granules. The granules produced using enzymatic extraction, granules prepared without enzymes, and control granules were evaluated through sensory assessment, physical quality analysis, total phenolic content, antioxidant activity (DPPH method), and crude fiber content. The results showed that enzyme-assisted extraction granules (EEG) exhibited significantly higher free radical scavenging activity (49.57 ± 6.10%) compared to non-enzymatic granules (NEG) (28.48 ± 8.67%). EEG also demonstrated a higher total phenolic content (0.027 g/100 g) than NEG (0.017 g/100 g). In addition, EEG showed better sensory acceptance and physical quality, including a more balanced taste, a stronger citrus aroma, and higher fiber content. These findings indicate that the application of the EAE method can enhance phenolic and fiber content, physical quality, and antioxidant activity of instant pomelo peel granules, suggesting their potential development as an environmentally friendly natural antioxidant product.
The use of Red Onion (Allium Cepa L.) Skin Extract as an Antioxidant and Anti-Inflammatory in Rats: A Literature Review Study Gede Agus Ari Tirtayasa; Maria Malida Vernandes Sasadara; Putu Era Sandhi Kusuma Yuda; Erna Cahyaningsih; Ni Luh Kade Arman Anita Dewi
Journal of Creative Power and Ambition (JCPA) Vol. 4 No. 01 (2026): Journal of Creative Power and Ambition (JCPA)
Publisher : CV Edujavare Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70610/jcpa.v4i01.1145

Abstract

Red onion peel (Allium cepa L.) is an agricultural by-product that contains high levels of bioactive compounds, particularly flavonoids and quercetin, which are known to possess antioxidant and anti-inflammatory properties. This systematic literature review aims to analyze the scientific evidence regarding the effects of red onion peel extract on antioxidant and anti-inflammatory activities in mouse models. Data were collected from international databases and selected based on relevance to in vivo and in vitro studies published between 2020 and 2025. The findings indicate that red onion peel extract significantly enhances antioxidant defense mechanisms by increasing the activity of superoxide dismutase (SOD), catalase, and total antioxidant capacity (ORAC), while reducing oxidative stress markers such as nitric oxide (NO) and inducible nitric oxide synthase (iNOS). In addition, the extract exhibits strong anti-inflammatory effects through the suppression of pro-inflammatory cytokines, including IL-1α, IL-1β, IL-6, and TNF-α, as well as inhibition of key signaling pathways such as JAK-STAT, NF-κB, and NLRP3/caspase-1. The effectiveness of the extract is influenced by dosage, duration of administration, and extraction method, with higher doses and longer exposure generally producing stronger biological effects. Overall, red onion peel extract shows promising potential as a natural source of antioxidant and anti-inflammatory agents for nutraceutical and therapeutic applications.
Co-Authors Adinda Puspita Elisabet Lian Erna Cahyaningsih Gede Agus Ari Tirtayasa I Gusti Ayu Sri Candramukhi Devi Dasi Intan Alfira Kolifay Ni Kadek Lita Ni Luh Kade Arman Anita Dewi Ni Putu Jayanti Putri Putu Era Sandhi Kusuma Yuda