Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer
Bekhet, Marwa
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
LncRNA in Hepatic Cancer: Diagnosis, Prognosis, and Therapeutic Targeting Abady, Mariam M; Shalaby, Reham A; Bekhet, Marwa
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1395

Abstract

Long non-coding RNAs (lncRNAs) are abundant in the genome and play important regulatory roles. However, classifying and annotating lncRNAs is challenging due to their diverse isoforms, complex functions, and interactions with other genes. Unlike protein-coding genes, lncRNAs exhibit dynamic changes, cell-specific characteristics, and influence various physiological and developmental processes. Dysregulation of lncRNAs is associated with genetic, immunological, metabolic, and tumoral diseases, including liver cancer, a highly lethal malignancy. In liver carcinogenesis, lncRNAs interact with proteins, DNA, and RNA to modulate gene expression, activate oncogenes, or inhibit tumor-suppressor genes. Therapeutic targeting of lncRNAs has emerged as a promising approach for cancer treatment, although clinical trials have shown varying efficacy and toxicity. This review summarizes recent advances on the role of lncRNAs in liver cancer, focusing on their involvement in tumor progression, metastasis, and drug resistance. It highlights their potential as diagnostic, prognostic, and therapeutic targets, discusses key challenges in lncRNA research, and explores emerging strategies for their clinical application in precision medicine.
Co-Authors Abady, Mariam M Shalaby, Reham A