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All Journal Journal of Computer Science Advancements Techno Agriculturae Studium of Research
Abakar, Sonia
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Agriculture, Biological Sciences & Forestry Computer Science & IT

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THE USE OF RECOMBINANT DNA TECHNOLOGY TO ENHANCE BETA-CAROTENE CONTENT IN CASSAVA (GOLDEN CASSAVA) Abakar, Sonia; Ali, Fatima; Saleh, Mahamat
Techno Agriculturae Studium of Research Vol. 2 No. 6 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/agriculturae.v2i6.2965

Abstract

Cassava (Manihot esculenta) is a staple crop widely grown in tropical regions, providing a major source of carbohydrates. However, its nutritional content is limited, particularly in essential micronutrients such as provitamin A. Beta-carotene, a precursor of vitamin A, plays a critical role in human health, particularly in preventing vitamin A deficiency, which is prevalent in many developing countries. Enhancing beta-carotene content in cassava could significantly improve its nutritional value and address public health concerns related to micronutrient malnutrition. The objective of this study is to use recombinant DNA technology to genetically engineer cassava varieties with enhanced beta-carotene content, creating what is commonly referred to as “Golden Cassava.”This research employed genetic transformation techniques, specifically Agrobacterium-mediated transformation, to introduce genes responsible for the biosynthesis of beta-carotene into cassava. Candidate genes, including those from the daffodil and maize, were selected to enhance the carotenoid biosynthesis pathway. Transgenic cassava plants were developed, and molecular analysis, including PCR and Southern blotting, was used to confirm the presence and integration of the introduced genes. Beta-carotene content in the transgenic plants was measured using high-performance liquid chromatography (HPLC). The results showed that the genetically modified cassava plants exhibited a significant increase in beta-carotene content compared to the wild-type varieties. The transgenic lines demonstrated enhanced nutritional quality without affecting other agronomic traits. In conclusion, recombinant DNA technology has proven to be an effective tool for biofortifying cassava with beta-carotene. This approach offers a promising strategy for addressing vitamin A deficiency and improving the nutritional value of cassava in regions where it is a major food source.
SAVING THE WORLD IN DNA: RECENT PROGRESS IN DNA STORAGE TECHNOLOGY IN 2026 Abakar, Sonia; Gaba, Brahim; Saleh , Mahamat
Journal of Computer Science Advancements Vol. 3 No. 3 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jsca.v3i3.3336

Abstract

The exponential expansion of the global datasphere is rapidly outpacing the physical and environmental capacity of silicon-based storage media. This study investigates the efficacy of a novel “dynamic-corrective” enzymatic synthesis architecture to address the critical cost and latency bottlenecks hindering the commercial adoption of DNA data storage. Utilizing a quantitative “bits-to-molecules-to-bits” experimental framework, we benchmarked an engineered Terminal Deoxynucleotidyl Transferase (TdT) protocol against traditional phosphoramidite chemistry, encoding a 10-terabyte heterogeneous dataset protected by hybrid LDPC-fountain codes. Empirical results demonstrate that the enzymatic system achieved a sustained write latency of 250 milliseconds per nucleotide and a synthesis cost of $0.05 per megabyte, representing a 70,000-fold reduction over chemical baselines. The system maintained a high logical density of 3.6 bits per nucleotide with 100% data recovery, while silica encapsulation proved stability equivalent to 500 years of aging. We definitively conclude that 2026-era enzymatic synthesis has matured into a scalable industrial solution, validating DNA as a robust, zero-energy archival medium essential for decarbonizing the future of global information infrastructure.
Co-Authors Ali, Fatima Gaba, Brahim Saleh , Mahamat Saleh, Mahamat