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All Journal Window of Health : Jurnal Kesehatan
Zaw Myo Hein
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Medicine & Pharmacology Nursing Public Health

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In Silico of AMHRII Receptor Binding and Toxicity Prediction of Clitoria ternatea Kurniawati, Erna Yovi; Mahati, Endang; Zaw Myo Hein
Window of Health : Jurnal Kesehatan Vol 7 No 4 (October 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v7i4.1166

Abstract

Clitoria ternatea compounds show significant potential as herbal drug candidates for polycystic ovary syndrome (PCOS) through improving anti-Müllerian hormone (AMH) parameters. This study aims to evaluate the potential of these compounds in binding to AMHRII receptors using an in silico approach. Several compounds, baicalein, isorhamnetin, and malvidin, showed high binding affinity towards AMHRII receptors, approaching or even surpassing some control drugs. These compounds have favorable toxicity profiles, with high LD50s, suggesting low toxicity and high safety potential for therapeutic use. Some compounds, such as isorhamnetin, termination, petunidin, malvidin, cyanidin, luteolin, and protocatechuic acid, have an unfavorable number of hydrogen donors, as does gallic acid, which has an unfavorable number of hydrogen acceptors. The development of technologies that improve bioavailability and pharmacokinetics can overcome these challenges. Further studies in vivo are needed to confirm the effectiveness and safety of these compounds in potential clinical therapies and develop innovative herbal therapies for Clitoria ternatea-based PCOS.
Co-Authors Endang Mahati Kurniawati, Erna Yovi