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All Journal Journal of Biomedical and Techno Nanomaterials Journal of Humanities Research Sustainability
Perera, Dilshan
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Humanities Biochemistry, Genetics & Molecular Biology

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LIPID NANOPARTICLE-MEDIATED MRNA DELIVERY FOR A NOVEL UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS SUBTYPES Pradeep, Lakshan; Wijerathna, Kumudu; Perera, Dilshan
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2974

Abstract

Influenza viruses continue to pose a major global health challenge due to rapid antigenic drift and shift, which limit the effectiveness of seasonal, strain-specific vaccines. Current vaccine strategies require frequent reformulation and often fail to provide broad and durable protection against diverse influenza virus subtypes. This study aims to develop a lipid nanoparticle–mediated mRNA delivery platform encoding conserved influenza antigens as a novel universal vaccine strategy. An experimental preclinical design was employed, involving in vitro transcription of mRNA, formulation into lipid nanoparticles, physicochemical characterization, and immunological evaluation in animal models. Particle size, encapsulation efficiency, mRNA expression, and stability were systematically assessed, followed by analysis of humoral and cellular immune responses and heterologous viral challenge studies. The mRNA–LNP vaccine exhibited uniform nanoscale properties, high mRNA integrity, and efficient antigen expression. Immunization induced robust cross-reactive antibody responses and strong CD4? and CD8? T-cell activation against multiple influenza subtypes. Vaccinated subjects demonstrated reduced viral loads, attenuated disease severity, and improved survival following heterologous influenza challenge. These findings indicate that lipid nanoparticle–mediated mRNA delivery of conserved influenza antigens represents a promising and adaptable platform for universal influenza vaccination, with significant potential to enhance pandemic preparedness and long-term influenza control.  
Ecological Epistemology In Indonesian Philosophical Thought Tracing The Roots Of The Concept Of Alam (Nature) In Nusantara Philosophy Judijanto, Loso; Perera, Dilshan; Nowak, Andrzej
Journal of Humanities Research Sustainability Vol. 2 No. 2 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jhrs.v2i2.2539

Abstract

Background. The concept of alam (nature) in Indonesian philosophical thought reflects a deep integration of ecological understanding, cultural wisdom, and spiritual values. Rooted in the diverse traditions of the Nusantara archipelago, alam embodies a worldview where the environment is not merely a physical space but a living system interconnected with human existence and morality. Despite its richness, the epistemological foundations of alam have received limited scholarly attention, particularly in relation to ecological philosophy. Purpose. This study aims to trace the roots of ecological epistemology in Indonesian thought by examining the cultural, historical, and philosophical constructions of alam across various local traditions. Method. A qualitative philosophical approach was employed, combining hermeneutic analysis of classical texts, oral traditions, and indigenous proverbs with comparative interpretation against contemporary ecological philosophy. Results. Findings reveal that the Nusantara concept of alam integrates cosmological balance, relational ethics, and community-based environmental stewardship. These elements parallel, and in some cases anticipate, modern sustainability principles while maintaining distinctive cultural expressions. Conclusion. The study concludes that ecological epistemology in Indonesian philosophy offers a valuable framework for rethinking environmental ethics in the global context, providing culturally rooted strategies for ecological resilience and sustainability.
Co-Authors Judijanto, Loso Nowak, Andrzej Pradeep, Lakshan Wijerathna, Kumudu