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All Journal Journal of Social Research Asian Journal of Social and Humanities
Rasyid, Shehnaz Neisa
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Humanities Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Social Sciences

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In Vivo Analysis Of Pandanus Tectorius Fruit Extract Gel: Modulation Of Epithelialization, Collagen Synthesis, And Fibroblast Proliferation In Wound Healing Sekarkusuma, Afifah; Putri, Vanessa Hedyana; Rasyid, Shehnaz Neisa; Kusuma, Maritza Cahya
Asian Journal of Social and Humanities Vol. 4 No. 3 (2025): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/8mv2dy67

Abstract

Herbal therapies are increasingly explored for wound management due to their perceived safety compared with synthetic agents. Pandanus tectorius contains bioactive compounds with potential benefits for tissue repair; however, evidence supporting its efficacy in incision remains limited. This study aimed to evaluate the effects of Pandanus tectorius ethanol extract gel on epithelialization, collagen density, and fibroblast proliferation in incision wounds of Rattus norvegicus. A post-test-only control-group experimental design was conducted using 30 white rats, allocated into five groups: positive control (Bioplacenton®), negative control (gel base), and extract gel treatments at concentrations of 10%, 20%, and 30%. Histological evaluations of epithelialization, fibroblast count, and collagen density were performed. Data were analyzed using ANOVA with Duncan’s post hoc test. Fibroblast proliferation differed significantly among groups (p < 0.001; ?² = 0.590). The 20% and 30% extract groups demonstrated the highest fibroblast counts. Collagen density showed a non-normal distribution in the negative control group, though overall variances were homogeneous. ANOVA did not reveal statistically significant differences in collagen density; however, Duncan’s test suggested a tendency toward increased collagen formation in the 30% extract group. The results indicate that Pandanus tectorius extract gel enhances tissue regeneration by significantly promoting epithelialization and fibroblast proliferation. Although the collagen in improvement was not statistically significant, the observed upward trend supports the extract’s potential role in extracellular matrix formation. Overall, Pandanus tectorius fruit extract gel shows promise as a natural wound-healing agent, warranting further research to optimize doses and assess clinical applicability.
The Relationship Between Depression Symptoms Measured by The Patient Health Questionnaire-9 and Blood Sugar Levels in Type 2 Diabetes Mellitus Outpatient Patients at Raden Achmad Basoeni General Hospital, Mojokerto, East Java, 2025 Rasyid, Shehnaz Neisa; Nandaka, I Ketut Tirka; Purwaningsari, Diah
Journal of Social Research Vol. 5 No. 3 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i3.3072

Abstract

The purpose of this research was to determine the correlation of depressive symptoms in patients with T2DM on 2-hour postprandial (PP) blood sugar levels. This research was an analytical observational (quantitative) study with a cross-sectional design and a simple random sampling technique. This study was conducted at R.A Basoeni Regional General Hospital, Mojokerto, East Java. Depressive symptoms were measured using the Patient Health Questionnaire-9 (PHQ-9), while 2-hour PP blood sugar levels were measured using a glucometer conducted in July-August 2025 with 101 respondents. The data obtained were analyzed using the Chi-Square test to determine the correlation between the two variables. The results of this study indicate a significant correlation with p = 0.010 and ? = 0.05, which mean p < ?. Therefore, it can be concluded that there is a statistically significant relationship between depressive symptoms and 2-hour postprandial blood sugar levels in patients with T2DM. This finding confirms that depressive symptoms play a significant role in influencing blood sugar stability in patients with T2DM.
Co-Authors Diah Purwaningsari I KETUT TIRKA NANDAKA Kusuma, Maritza Cahya Putri, Vanessa Hedyana Sekarkusuma, Afifah